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  • Ebm On Therapy

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    wurifresh
    11 Ansichten13 Seiten
    This document discusses the validity of a study comparing ticagrelor versus clopidogrel in patients with acute coronary syndromes. It lists 7 criteria for determining validity: 1) randomization of treatment assignment, 2) concealment of randomization, 3) similarity of groups at start of trial, 4) sufficiently long and complete follow-up, 5) analysis of patients in original randomized groups, 6) blinding of patients, clinicians and personnel to treatment, and 7) equal treatment of groups apart from experimental therapy. For each criterion, it notes that the MRC trial referenced in the title appeared to be randomized based on the title and methods require checking another article for full details.

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    Ebm on Therapy

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    This document discusses the validity of a study comparing ticagrelor versus clopidogrel in patients with acute coronary syndromes. It lists 7 criteria for determining validity: 1) randomization of treatment assignment, 2) concealment of randomization, 3) similarity of groups at start of trial, 4) sufficiently long and complete follow-up, 5) analysis of patients in original randomized groups, 6) blinding of patients, clinicians and personnel to treatment, and 7) equal treatment of groups apart from experimental therapy. For each criterion, it notes that the MRC trial referenced in the title appeared to be randomized based on the title and methods require checking another article for full details.

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    11 Ansichten13 Seiten

    Ebm On Therapy

    Hochgeladen von

    wurifresh
    This document discusses the validity of a study comparing ticagrelor versus clopidogrel in patients with acute coronary syndromes. It lists 7 criteria for determining validity: 1) randomization of treatment assignment, 2) concealment of randomization, 3) similarity of groups at start of trial, 4) sufficiently long and complete follow-up, 5) analysis of patients in original randomized groups, 6) blinding of patients, clinicians and personnel to treatment, and 7) equal treatment of groups apart from experimental therapy. For each criterion, it notes that the MRC trial referenced in the title appeared to be randomized based on the title and methods require checking another article for full details.

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    von 13

    EBM On THERAPY

    KLMPK 2
    Search Strategy
    Medline database :

    http://www.ncbi.nilm.nih.gov/pubmed
    Ticagrelor versus clopidogrel in
    patients with acute coronary
    syndromes.
    Wallentin et all.,
    N Engl J Med. 2009 ;361(11):1045-57.
    ARE THE RESULTS OF THIS STUDY
    VALID?
    Validit 1.Was the assignment of patients
    y to treatment randomized?

    In the MRC trial that we found to answer


    our question about the effectiveness of
    statin therapy, the title states that it is a
    randomized trial, and a quick scan of the
    methods refers us to another article for
    complete details.
    Validit 2.Was the randomization
    y concealed?
    In the MRC trial that we found to answer
    our question about the effectiveness of
    statin therapy, the title states that it is a
    randomized trial, and a quick scan of the
    methods refers us to another article for
    complete details.
    Validit 3.Were the groups similar
    y at the start of the trial?
    In the MRC trial that we found to answer
    our question about the effectiveness of
    statin therapy, the title states that it is a
    randomized trial, and a quick scan of the
    methods refers us to another article for
    complete details.
    Validit 4.Was follow-up of patients
    y sufficiently long and complete?

    In the MRC trial that we found to answer


    our question about the effectiveness of
    statin therapy, the title states that it is a
    randomized trial, and a quick scan of the
    methods refers us to another article for
    complete details.
    Validit 5.Were all patients analyzed in the
    groups to which they were
    y randomized?

    In the MRC trial that we found to answer


    our question about the effectiveness of
    statin therapy, the title states that it is a
    randomized trial, and a quick scan of the
    methods refers us to another article for
    complete details.
    Validit 6.Were patients, clinicians, and
    study personnel kept blind to
    y treatment?

    In the MRC trial that we found to answer


    our question about the effectiveness of
    statin therapy, the title states that it is a
    randomized trial, and a quick scan of the
    methods refers us to another article for
    complete details.
    Validit 7. Were groups treated equally,
    apart from the experimental
    y therapy?

    In the MRC trial that we found to answer


    our question about the effectiveness of
    statin therapy, the title states that it is a
    randomized trial, and a quick scan of the
    methods refers us to another article for
    complete details.

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