Beruflich Dokumente
Kultur Dokumente
Genetic Of Diabetes
Mellitus
1 2 3
Type 1 DM Type 2 DM Monogenic
form of
Diabetes
Histology of Pancreas
Insulin synthesis and secretion
Insulin action
1 Type 1 Diabetes
Mellitus
Pathogenesis
an autoimmune disease: pancreatic
islet destruction caused by T
lymphocytes reacting against poorly
defined B-cell antigens
Pathogenesis:
Genetic susceptibility cell
destruction
Environmental Factor ( > 90%
manifest)
Mechanisms of cell destruction
cell destruction
3. Predisposing and precipitating virus
2 Type 2 Diabetes
Mellitus
Pathogenesis
Type 2 Diabetes Mellitus
DM because :
Not enough insulin is being made
The body tissue are not responding
proprly to insulin
Pathogenesis:
ability of peripheral tissue to insulin
(insulin resistance)
cell dysfunction (inadequate insulin
secretion)
Insulin resistance