By: TAYYABA ISRAR KHAN Reg no: 2010-va-30 Trypanosomiasis Trypanosomiasis is a protozoan disease of livestock commonly called as Surra caused by a protozoan organism Trypanosoma evansi. The disease is transmitted by Tabanid flies. It affects most of the livestock and wild animals also. It is distributed throughout India and found as endemic. The disease is seen as an outbreak in pre monsoon and in monsoon seasons due to active breeding of the Tabanid flies. The disease is characterized by anemia, nervous complications, emaciation and death. It causes severe loss to the farmers by way of poor milk and meat production, reduced ability to work and high mortality. The disease also interferes with immunity and causes immunosuppression of bacterial and Transmission and pathogenesis of the disease Trypanosiasis is transmitted by a vector Tabanid fly (Horse fly). The fly passively transfer the parasites from the infected animal by sucking along with the blood and regurgitating into another animal. the parasites can briefly live in the gut of the fly. Other vectors capable of infecting are Stomaxys, Lyperosia, Hematopota (Flies), Ornithodorus (Ticks). Trypanosomes after reaching the blood stream of the host quickly deplete the blood sugar levels by consuming large quantities of sugar and develop hypoglycemia. They also produce disturbances in protein metabolism in the hosts body. They also cause destruction of the red blood cells and produce anemia. Clinical symptom The disease in cattle and buffaloes runs in per acute, acute and chronic forms depending on the strain of the parasite. In acute form there will be intermittent fever ranging from 39 to 41 degrees Celsius, conjunctivitis, and lachrymation Sudden drop of milk yield Labored breathing Nervous symptoms like walking in circles, beating the head on mangers, or walls, twitching of the muscles and the animal may go coma leading to death of the animal. Diagnosis A wet drop of blood can be obtained from the ear or tail vein and examined in high power. The moving parasites can be seen in the wet blood Serological tests can also be made to identify the antibody formation using PCR, ELISA, agglutination tests for laboratory diagnosis of the disease. Treatment: Quinapyramine sulfate, Quinapyramine chloride (Antrycide and Antrycide prosalt), Demenazene aceturate (Berenil), Suramin (Naganol). Antrycide prosalt can also be used as a prophylactic drug to protect the animals in endemic areas during pre monsoon periods. Prevention of the disease Quick diagnosis and prompt treatment of affected animal controls the disease to some extent. In endemic areas prophylactic treatment with Antrycide prosalt administration controls the disease. Effective methods for fly control should be followed to control breeding of the flies. Spraying of the dung pits, clearing of the bushes around the cattle sheds by burning, spraying insecticides on the animals etc should be followed.