Acidul Folic

(acidum folicum)

Alin ICHIM
Farmacie III- UTM
 Definitie si caracteristici

vitamina B9, vitamina Bc, vitamina M, folat si pteroyl-L-glutamate.

C19H19N7O6 Mr 441.4
CAS [59-30-3]
DEFINITIE
(2S)-2-[[4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-
yl)methyl]amino]benzoyl]amino]pentanedioic acid.
Coninut: 96.0 102.0 % (substanta uscata).
CHARACTERISTICI
Aspect: pudra cristalina, galben-oranj;
Solubilitate: practic insolubila in apa si majoritatea solventilor organici. Solubila
in acizi diluati si solutii alcaline.
 Definitie si caracteristici
Folatii sunt un grup de compusi
heterociclici cu parte comuna a
scheltului
4-[(pteridin-6-ylmethyl)amino]benzoic
acid
Conjugati cu una sau mai multe
grupariL-glutamat.

http://www.chem.qmul.ac.uk/iupac/misc/folic.html#28
Acid pteroic
 Conjugati glutamat

The compounds in which pteroic acid is conjugated with one or more molecules ofL-glutamate are named
pteroylglutamate, pteroyldiglutamate, etc. (The name pteroylmonoglutamate is not used. See also
paragraph 2.4) It is assumed that the second and subsequent molecules of glutamate are each linked by
amide bonds to the preceding molecule of glutamate through the-carboxyl of the latter, thus:
These terms may also be used in a generic sense. Thus 'pteroylhexaglutamates' may be used to designate
any compounds with this basic structure, or a mixture of them, regardless of the state of reduction of the
pteridine ring or one-carbon substitutions on the reduced pteridine ring. The term 'pteroylpolyglutamates'
has a still broader connotation, applying to all members of the family with more than one glutamate
residue.
Biozinteza I
Biozinteza II
 Simptome ale deficientei
Anemie;
Dispnee;
Oboseala;
Palpitatii;
 Efecte asupra sanatatii
Sarcina: aportul de folati in timpul
sarcinii a fost legat de scaderea
incidentelor defectelor de tub neuronal
la nou nascuti;
Fertilitate:Este necesar pentru
asigurarea fertilitatii atat la barbati cat
si la femeie. Contribuie la
spermatogeneza.
 Efecte asupra sanatatii
Importand in diviziunea rapida a
celulelor implicatii in tratarea
cancerului;
Folic, B12 si Fe au interactii complexe
intre ele astfel deficienta unui
component poate fi mascata de
excesul altuia.
 Surse de folati
Spanac, salata, asparagus, sfecla,
fasolea, mazare, linte, broccoli
Oua.
Drojdia
Semintele de floarea soarelui
Rinichii si ficatul.
 Bibliografie
European Pharmacopoeia
http://www.chem.qmul.ac.uk/iupac/mi
sc/folic.html#28
http://www.chem.qmul.ac.uk/iubmb/e
nzyme/reaction/misc/folate1.html
https://en.wikipedia.org/wiki/Folic_aci
d