FISIOLOGI ENDOKRIN

Oleh Tri Pitara

mastripitara@yahoo.com
 BIODATA
Nama : TRI PITARA M
Tempat Tanggal Lahir : Yogyakarta, 6 Juni 1968
Pendidikan : S1,S2 UGM & S3 di UB
Alamat : Jl. Kaliurang KM 9, Griya
Karangmojo
Indah No 31 Yogyakarta
Pekerjaan : Dosen Fakultas Kedokteran UMY.,

Kepala Bagian Fisiologi Kedokteran

Prodi Pend .
Dokter

Direktur Avisiena Consultant

Anggota Pengurus KBIH Multazam Yogya
Nara sumber GOLDEN SOLUTION Bersama Mas Tri Pitara di Radio
Pro2 FM 102.5 Mhz,RRI, tiap Hari Sabtu jam 19:30-21:00. (streaming :
www.rripro2jogja.co.id)
Apa itu Endokrinologi ?
SISTEM NEUROENDOKRIN
Jalur Neuroendokrin
STRESSOR, FUNGSI SISTEM ENDOKRIN
dan IMUNITAS
Emotional stress Environmental stress Xenobiotics

Physiology / Function

Nervous system Immune system

Endocrine system
STRESS:
Anystimulationthatdisruptsthe
HOMEOSTASISofthebody.
DIFFERENCESINSTRESSRESPONSE

1.Speciesdifferences
2.Prenatalexperience
3.Neonatalexperience
4.Socialstatus
5.Individualpersonality
temperament
 FEMALE HPA AXIS
Higher Centres

Hypothalamus

FEMALE HPA AXIS

Luteinizing Hormone-Releasing Hormone

(LHRH)

positive and
Luteinizing Hormone Follicular Stimulating Hormone
negative Androgen
(LH) (FSH)
feedback

aromatising hormone

Oestradiol (O2)
and oestrone (O1)
 MALE HPA AXIS
Higher Centres

Hypothalamus

Luteinizing Hormone-Releasing Hormone

(LHRH)

Direct negative
Inhibin ?
feedback
direct
feedback
Luteinizing Hormone Follicular Stimulating Hormone
Oestradiol Testosterone
(LH) (FSH)

Leydig cells Sertoli cells

 Hypoactivity of HPA axis
Fatigue
Inflammation
Autoimmune disease Weakness
Myocardial infarction Loss of libido
Apathy Pain
Anorexia Asthma
Weight loss Allergies
Insomnia Loss of mental
concentration
 Hyperactivity of the HPA
axis
GI tract disorders
Anxiety
Central obesity
Agitation
Loss of muscle tone
Insomnia
Osteoporosis
Hypercholesterolaemia
Loss immune function
Increased triglycerides
Poor recovery from
Fatigue
illness or injury
Depression Infertility
Hypertension Reduced kidney
function