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MENSTRUAL CYCLE
Dr.dr.Kms.Yusuf Effendi, SpOG(K)
LEARNING OBJECTIVES
Negative Estrogen
Feedback FSH
Mechanism LH
Stimulates
Inhibits
OVARIAN CYCLE
Follicular phase
Theca and granulosa cells responds to LH and FSH
stimulation produce oestrogen, progesterone,
inhibin and activin.
Ovulation
The dominant follicle grow to 18-22 mm at 14 days
Luteal phase
After the release of the oocyte, the remaining
granulosa and theca cells on the ovary form the
corpus luteum.
Menstrual phase
Proliferative phase
Secretory phase
Absent
Regularity of
Irregular: Variation >20 d
menses
Regular: Variation 2 20 d
Prolonged: >8 d
Duration of
Normal: 4.5 8 d
flow (days)
Short: <4.5 d
2 important effects:
- Primary oocyte of dominant
follicle completes meiosis
- After meiosis 1 is complete
ovulation.
ROLE OF ESTRADIOL