Beruflich Dokumente
Kultur Dokumente
VANESSA T. UCAT, RN
MSN 302
DECEMBER 2015
Asthma is a chronic disease characterized
by recurrent attacks of breathlessness and
wheezing, which vary in severity and
frequency from person to person.
Etiology
Asthma commonly results from
hyperresponsiveness of the trachea and bronchi
to irritants.
Allergy influences both the persistence and the
severity of asthma, and atopy or the genetic
predisposition for the development of an IgE-
mediated response to common airborne
allergens is the most predisposing factor for the
development of asthma.
It has been divided into two basic types:
1. Extrinsic asthma.
2. Intrinsic asthma.
Sometimes extrinsic and intrinsic can co-exist in
the same patient
Extrinsic (atopic, allergic) Asthma Intrinsic (non-
70% atopic)Asthma 30%
- Initiated by type 1
hypersensivity reaction induced - Initiated by diverse,
by exposure to extrinsic non-immune
antigen/allergens e.g. food, pollen, mechanisms e.g.
dust, etc. infections, drugs like
aspirin, inhaled chemical
- Subtypes include: irritants, cold, stress and
a) atopic (allergic)asthma. exercise.
b) occupational asthma. - No personal or family
c) allergic bronchopulmonary
history of allergic
aspergillosis. reaction.
- Develop early in life - Develop later in life
Symptoms
tightness in the chest
difficulty in breathing or shortness of
breath
wheezing
coughing
Asthma Triggers may include
Tobacco smoke
Infections such as colds, flu, or pneumonia
Allergens such as food, pollen, mold, dust mites, and
pet dander
Exercise
Air pollution and toxins
Weather, especially extreme changes in temperature
Drugs (such as aspirin, NSAID, and beta-blockers)
Emotional stress and anxiety
Singing, laughing, or crying
Smoking, perfumes, or sprays
Acid reflux
10 facts of Asthma according to
World Health Organization
WHO estimates show that 235
million people currently suffer from
asthma.
Asthma deaths will increase in the next 10
years if urgent action is not taken.
Pollen
House Dust Mites
Mold
Animal Hair and Dander
PATHOPHYSIOLOGY
PATHOPHYSIOLOGY
Exposure to environmental factors such as cold, smoking, and pollutants
IgE antibodies are produced as an immune response
IgE attaches to the mast cells of the lungs
Re-exposure to antigens in the environment results in the antigen binding to the antibody
Mast cell products (chemical mediators) are released histamine, bradykinin, prostaglandin
Mediators affects smooth muscles causing bronchospasm and mucous membrane swelling
Airways are obstructed
Dyspnea
ASTHMA
LABORATORY FINDINGS
LUNG FUNCTION TEST