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Stimulated by TSH
Inhibited by Potassium Perchlorate
Iodination
I I2
I2 + Thyroglobulin MIT and DIT
Inhibited by methimazole & PTU
Release
Condensation
Overproduction of endogenous H
Hyperthyroidism Exposure to excess exogenous H
Drug for Hypothyroidism
Levothyroxine
Isomer T4 , some are converted to T3
Long half life
Steady state : 6 - 8 weeks
Toxicity hyperthyroidism: Arrhythmia, tachycardia, anginal pain, etc.
Precautions: Heart disease
Surgical
Radioiodine (removal Destruction by radioactive iodine (131I)
thyroid gld.) which emitted beta particles
Inhibiting hormone synthesis
Methimazole
Propylthiouracil
Adverse reactions:
Ulceration of mucous membranes
Metallic taste in the mouth
rashes
Blocking the action
CO
hyperhydrosis
tremor
Low cost
Thyroid gland hyperfunction cells
destruction
Dose: 140-160 micro Ci/gr or 80
micro Ci/gr
Discontinuation of drug
treatment
After 12-18 months of therapy
Relapse usually occurs within the 1st 3-6
months after medication is stoped.
75% of women in remission who became
pregnant will have a postpartum relapse
of graves disease.
Life long follow up after remission
Relapse therapy: radioiodine
(methimazole before it)
Pregnancy
CI : radioiodine,
propanololteratogenic effect
Surgery, antithyroid (low dose PTU)
Fever,delirium,tachycardi,dehydration.
PTU: 300 mg/6 hours