NYSTATIN

BY :

BANGBANG BUHARI 020100098

LUCIA AKTALINA 020100102
NADIA AMALIA 020100104

Department of Pharmacology and Therapeutics

Faculty of Medicine
Universitas Sumatera Utara
 NYSTATIN
Chemical structure :

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 NYSTATIN
Polyene antifungal
Obtained from Streptomyces noursei
Yellow reddish powder
Unsoluble in chloroform & ether
Has specific smell
Stable in dry place, not in water or
plasma
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 Brand name :
Mycostatin
Nilstat
Nyaderm
PMS - Nystatin Mykinac
Nystec
O-V Statin

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 Pharmacokinetic
Absorbtion
Mucous membrane & skin (-) absorption
Gastrointestinal insignificant.

Distribution & Metabolism (-)

Excretion
Oral administered passed unchanged
in the stool.
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 Pharmacodynamic
Binds to ergosterol in the fungal
membrane

Disrupts osmotic integrity of the

fungal membrane

Leakage of intracellular potassium,

magnesium, sugars, and metabolites

Cellular death 5
 Indication
Treat fungal infections on :

Skin

Mouth

Vagina

Intestinal tract

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 Side Effect

Gastrointestinal : - diarrhea
- nausea
- vomiting
- GI disturbances

Dermatologic : - rash, urticaria

- Stevens-Johnson syndrome

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 Toxic Effect
No serious toxic effect have been found

Contraindication
Hypersensitivity
Pregnancy and breastfeeding
Category C
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 Dose
1mg 200 unit nystatin
Vaginal cream/tablet 100.000 unit/tablet
Oral Tablet 500.000 unit/tablet
Suspensi/oral drops 100.000 unit/ml
Oral & oesophagus candidiasis 500.000-
1.000.000 units 3-4 dd
Infants 2ml (200.000 units) 4dd
Children & adults 4-6ml 4dd
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 Drugs interaction
No information provided

Drugs with same effect

Amfoterisin B
Clotrimazol
Mikonazol

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 Conclutions
Patient with imunosuppressed
opportunistic Candidiasis
Parenteral nystatin high toxicity
Nystatin is topical fungisidal especially
for Candida albicans

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