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Kultur Dokumente
ethionamde
Isoniazid (H) amikacin,kanamycin
Rifampicin (R) cycloserine
Pyrazinamide (Z) ciprofloxacin
clarithromycin,
Streptomycin (S)
azithromycin
Ethambutol (E) dapsone
rifabutin
Treatment categories
sputum specimen sent for culture and drug sensitivity test (DST).
Rapid molecular DST should be done if available.
All patient should be referred to physician experience in treating drug
resistance TB for consideration of MDRTB regimen before DST
available.
Side Effects of Anti-Tuberculous Drugs
Isoniazid Rifampicin Pyrazinamide Streptomycin Ethambutol
Major -Peripheral -Hepatitis -Hyperuricaemia - 8th nerve -Retrobulbar
neuropathy -Rash -Hepatitis damage neuritis
-Hepatitis -GI disturbance -GI disturbance -Rash -Arthralgia
-Rash
Minor -Lupoid -Interstitial -Rash -Nephrotoxicity -Peripheral
reactions nephritis -Photo- -Agranulocytosis neuropathy
-Seizures -Thrombo- sensititasion -Rash
-Psychoses cytopenia -Gout
-Haemolytic
anemia
Management of TB in specific situation
a) Tuberculosis in pregnancy and lactation
-isoniazid ,rifampicin,ethambutol and pyrazinamide are safe to be used
-Streptomycin should be avoided (feotal ototoxicity)
-pyridoxine (25mg/daily) should be given to all prregant women( feotal neurotoxixity)
-first line antiTB are safe in breast feeding