METABOLISM IN CELL

Biochemistry Departement
Medical Faculty Of Andalas University
Padang
 Definitions:

Catabolism = the breakdown of

complex substances.

Anabolism = the synthesis of complex

substances from simpler ones.
 Amphibolic
Anabolisme dan Katabolisme:
terjadi dalam satu proses
metabolism
Siklus Kreb
Biosintesis heme, glukosa, asam
lemak
Katabolisme: sitrat, ketoglutarat
Overview Metabolisme
 cytosol Pyruvate

mitochondria
(aerobic) Acetyl CoA
FATTY ACIDS

Krebs Reducing
cycle equivalents
AMINO
ACIDS

Oxidative
Phosphorylation
(ATP)

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 Energi
Oxidation of fuels to generate ATP is called
respiration
Electrons lost from the fuels during oxidative
reactions : transferred to O2 by a series of
proteins in the electron transport chain
Energy of electron transfer : used to convert ADP
and Pi to ATP by a process known as oxidative
phosphorylation
Satuan Energi :
Calori
kilocalorie
kilojoules (kJ)
The ATP-ADP cycle
Integrasi Metabolisme KOH,Lipid,& Protein

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 Proteins Carbohydrates Fats

Proteins Glycogen Triglycerides (neutral fats)

Glucose
Amino acids
Glucose-6-phosphate Glycerol and fatty acids

Keto acids Glyceraldehyde phosphate

Pyruvic acid Lactic acid

NH3
Acetyl CoA
Ketone
Urea
bodies
Krebs
cycle
Excreted
in urine
Lots ATP
G-6-P
Low ATP
Need skeltons
YANG HARUS DIPAHAMI:

1. Glikolisis
2. Glikogenesis
3. Glikogenolisis
4. Glukoneogenesis
5. HMP-Shunt
6. Jalur Asam Uronat

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 Glikolisis
Disebut juga jalur metabolisme Embden-
Meyerhof.
Adalah jalur oksidasi glukosa menjadi
piruvat + energi (ATP) + NADH.
Glikolisis berlangsung dalam sitosol.
Glikolisis merupakan jalur sumber energi
terutama bagi sel darah merah matang
yang tidak lagi punya mitokondria.

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Overview of fatty acid metabolism
Overview of amino acid metabolism
Intracellular location and overview of major metabolic pathways
Integrasi Metabolisme Lipid

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