Beruflich Dokumente
Kultur Dokumente
NUCLEOTIDE
2016 Paul Billiet ODWS
Ribose is a pentose
C5
C4 C1
C3 C2
RIBOSE DEOXYRIBOSE
CH2OH CH2OH
O OH O OH
C C C C
H H H H H H H H
C C C C
OH OH OH H
2016 Paul Billiet ODWS
P
THE SUGAR-PHOSPHATE
BACKBONE P
direction
P
The phosphate group joins
the 3rd Carbon of one sugar
to the 5th Carbon of the next P
in line.
P
P
2016 Paul Billiet ODWS
T
Hydrogenbonds
P
G C
DNA IS MADE OF P
TWO STRANDS OF P
C G
POLYNUCLEOTIDE P
P
C G
P
P
A T
P
P
T A
P
P
2016 Paul Billiet ODWS T A
P
DNA IS MADE OF TWO STRANDS OF
POLYNUCLEOTIDE
The sister strands of the DNA molecule run in
opposite directions (antiparallel)
They are joined by the bases
Each base is paired with a specific partner:
A is always paired with T
G is always paired with C
Purine with Pyrimidine
Thus the sister strands are complementary but not
identical
The bases are joined by hydrogen bonds,
individually weak but collectively strong.
2016 Paul Billiet ODWS
Erwin Chargaffs Data (1950-51)
kentsimmons.uwinnipeg.ca/cm1504/Image265.gif
2016 Paul Billiet ODWS
Purines & Pyrimidines
Adenine Thymine
Guanine Cytosine
2016 Paul Billiet ODWS
Watson & Crick Base pairing