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Anemia deficiency iron (iron deficiency anemia) is a common type of anemia found in Indonesia. It is caused by insufficient iron intake or absorption. In the early stages, red blood cells appear normal in size and color, but later become microcytic and hypochromic. Bone marrow shows increased erythroid series. Serum iron levels decrease while total iron binding capacity increases. Serum ferritin also decreases. Laboratory tests show microcytic, hypochromic anemia with poikilocytosis, anisocytosis, and target cells on a peripheral blood smear.
Anemia deficiency iron (iron deficiency anemia) is a common type of anemia found in Indonesia. It is caused by insufficient iron intake or absorption. In the early stages, red blood cells appear normal in size and color, but later become microcytic and hypochromic. Bone marrow shows increased erythroid series. Serum iron levels decrease while total iron binding capacity increases. Serum ferritin also decreases. Laboratory tests show microcytic, hypochromic anemia with poikilocytosis, anisocytosis, and target cells on a peripheral blood smear.
Anemia deficiency iron (iron deficiency anemia) is a common type of anemia found in Indonesia. It is caused by insufficient iron intake or absorption. In the early stages, red blood cells appear normal in size and color, but later become microcytic and hypochromic. Bone marrow shows increased erythroid series. Serum iron levels decrease while total iron binding capacity increases. Serum ferritin also decreases. Laboratory tests show microcytic, hypochromic anemia with poikilocytosis, anisocytosis, and target cells on a peripheral blood smear.
FK.Universitas Methodist Indonesia Medan ANEMIA YANG SERING DI JUMPAI DI INDONESIA ANEMIA DEFISIENSI BESI ANEMIA INFLAMASI ANEMIA MEGALOBLASTIK ( DEF ASAM FOLAT ) ANEMIA HEMOLITIK - THALASEMIA OBAT OBATAN ANEMIA ec INSUFISIENSI RENAL ANEMIA GRAVIDARUM Distribusi besi Besi merupakan satu unsur terbanyak di kulit bumi, dan def besi merupakan sebab terbanyak anemia Kebutuhan tertinggi akan besi terjadi pada bayi berumur 1 tahun pertumbuhan sangat cepat di sertai pembentukan eritrosit yg intensif ( dibutuhkan 1 1,5 mg/hari ) Kehamilan/laktasi ( 2,5 4,0 mg/hari ) Jumlah total besi dalam tubuh 35 mg/kg pada wanita dan 50 mg/kg pada laki - laki Haemoglobin mengadung kira kira 2/3 besi tubuh Besi di angkut oleh transferin(beta globulin BM 80.000) ke dalam eritroblas di sst dan retikulosit Eritrosit di hancurkan RE dan besinya di bebaskan kedlm plasma dan sebagian di dalam RE sebagai haemosiderin dan Feritin Feritin adalah kompleks protein besi yg larut dlm air dgn BM 465000 Haemosiderin adalah kompleks protein besi yg tdk larut dlm air Iron Metabolism Absorption
Primarily in mucosa of proximal small intestine
Amount absorbed depends on Amount of iron ingested Form of ingested iron - ferric iron not easily absorbed Tissue iron stores inversely related to amount absorbed Condition of mucosal cells in GI tract Hematopoietic activity of bone marrow Intralumunial factors (parasites, toxins, etc) Iron Metabolism - Transport
Major iron transport protein is transferrin.
Each gram of transferrin will bind 1.4 mg of iron. Total transferrin present in plasma to bind 253-435 mg of iron/dL of plasma Total iron-binding capacity (TIBC) Serum iron concentration is 70 201 mg/dL 95% is complexed with transferrin Transferrin is about 1/3 saturated with iron (% saturation = serum iron/TIBC X 100%) The reserve iron-binding capacity of transferrin is called the unsaturated iron-binding capacity or UIBC (UIBC = TIBC serum iron) Most iron bound to transferrin comes from the breakdown of hemoglobin Excess iron deposited in tissues Iron metabolism - Storage
Major storage depot is liver
Stored as ferritin and hemosiderin Ferritin primary storage compound for bodys need Readily released for heme synthesis Small amounts found in blood parallels the storage iron in the body Hemosiderin Major long term storage form of iron Slow release Estimation of hemosiderin made on bone marrow tissue sections Iron Metabolism - Requirements Body iron conserved through reutilization only about 1 mg lost per day Iron deficiency occurs when negative iron balance Increased requirements Inadequate diet Malabsorption Iron overload when Increased absorption Multiple transfusions Iron injections Increased Iron Requirements
Menstruation menstruating females
have twice the daily requirements as males (2 mg/day) Pregnancy 3.4 mg/day Infancy/childhood rapid growth At birth, enough iron stores for 4-5 months Milk is poor source of iron Iron supplementation recommended Sebab anemia mikrositik hipokrom
Sideroblastic anemia Thalassaemia Iron Deficiency Anaemia of
chronic disease Gambaran darah tepi anemia def besi Pada permulaan adalah normositik normokrom, kemudian berubah menjadi mikrositik hipokrom dan pada yg sdh lanjut tampak anisositosis dan poikilositosis Retikulosit, Hb, Ht berkurang Sumsum tulang tampak hiperplasia seri eritrosit Kadar besi dlm serum menurun TIBC meningkat Feritin serum berkurang - Laboratorium : - SADT : anemi mikrositik, hipokromik, poikilositosis, target sel , anisositosis,