woman. Extrapolation of the linear portion of the drug disposition curve intersects the Y-axis at 30 mg/L. What is the volume of distribution? If a drug has an elimination rate constant (Ke) of 0.3 days-1, how much time is required for elimination of 95% of the drug? 3. A drug was present in the plasma of a patient at a concentration of 400 g/ml. 7 hours later, the concentration was 50 g/ml. Assuming that the drug is eliminated by zero order kinetics, how long did it take to reduce the original concentration by 50%? Assuming that the drug is eliminated by first order kinetics, how long did it take to reduce the original concentration by 50%? 4. The initial plasma concentration of a drug given iv at 9:00am is 250 mg/ml. If the half- life of the drug is 6 hours, perform a calculation to predict the plasma concentration will be at 9:00pm same day. 6. A patient visits her doctor with symptoms typical of a bladder infection. She is immediately prescribed a 400 mg dose of antibiotic (t = 12 h). The corresponding plasma concentration of drug is found to be 96 mcg/ml. What is the volume of distribution of this drug? The bioavailability of a new investigational drug was studied in 12 volunteers. Each volunteer received either a single oral tablet containing 200 mg of the drug, 5 mL of a pure aqueous solution containing 200 mg of the drug, or a single IV bolus injection containing 50 mg of the drug. Plasma samples were obtained periodically up to 48 hours after the dose and assayed for drug concentration. The average AUC values (048 hours) are given in the table below. From these data, calculate (a) the relative bioavailability of the drug from the tablet compared to the oral solution and (b) the absolute bioavailability of the drug from the tablet.