Beruflich Dokumente
Kultur Dokumente
Learning Objectives
Understand background knowledge of Marijuana and
Cannabis
Review different subspecies of Cannabis
Understanding of cannabinoids and endocannabinoid
system
Become aware of all possible sources of exposure
Discuss common side effects of THC
Discuss clinical presentation and monitoring of
cannabis intake
Inform on current pharmaceutical research (FYI)
Disclaimer
1) http://emedicine.medscape.com/article/833828-overview#a4
2) Mintz CS. Cannabis-derived pharmaceuticals. Journal of Commercial Biotechnology. 2015;21(3).
https://login.southuniversity.libproxy.edmc.edu/login?url=http://search.proquest.com/docview/1692507629?accountid=13931. doi: http://dx.doi.org/10.5912/jcb709.
3) Image from: http://blog-imgs-78.fc2.com/c/a/n/cannabis272/partsname.jpg on Sept.2016
Extra Fluff
Cannabis Indica
THC/CBD ratio
Higher concentrations of THC
than Sativa
Lower CBD concentration
Cannabis Sativa
CBD/THC ratio
Higher concentrations of CBD
Lower THC concentrations
Gertsch, J., Pertwee, R. G., & Di Marzo, V. (2010). Phytocannabinoids beyond the Cannabis plant do they exist? British Journal of Pharmacology, 160(3),
523529. http://doi.org/10.1111/j.1476-5381.2010.00745.x
Pathophysiology
By reducing inflammatory cell infiltration and lipid peroxidation, CB2-R receptor activation is protective against hepatic ischemia-reperfusion injury. Targeting the hepatic ECS may have therapeutic potential in a
variety of liver diseases.[26]. (n.d.). Endocannabinoids. Retrieved September 26, 2016, from http://emedicine.medscape.com/article/1361971-overview#a4
Table 1: Pharmacologically active phytocannabinoids
Therapeut ic
Name Abbreviat ion St ruct ure Physiologic Ef ect s Indicat ion(s)
By reducing inflammatory cell infiltration and lipid peroxidation, CB2-R receptor activation is protective against hepatic ischemia-reperfusion injury. Targeting the hepatic ECS may have
therapeutic potential in a variety of liver diseases.[26]. (n.d.). Endocannabinoids. Retrieved September 22, 2016, from http://emedicine.medscape.com/article/1361971-overview#a3
Pathophysiology
Cannabinoid Poisoning Treatment & Management. (n.d.). Retrieved September 22, 2016, from http://emedicine.medscape.com/article/833828-treatment#d9
Image from: http://bluebell-web-solutions.com/wp-content/uploads/2016/01/Social-Media-Monitoring.jpeg on Sept.2016
Monitoring Parameters
THC
Metabolized via the hepatic cytochrome P450 (CYP) system
Half-Life: 2-56hrs
15% excretion in the urine and 25-35% in the feces
~90% of THC is eliminated from the body in 5 days
Dronabinol (Marinol)
Antiemetic; Appetite Stimulant
Onset of action: ~0.5 to 1 hour
Peak effect: 2 to 4 hours
~10 L/kg; dronabinol is highly lipophilic
Protein binding: ~97%
Excretion: Feces (50%, 5% as unchanged drug); Urine (10% to 15%)