Beruflich Dokumente
Kultur Dokumente
1
Multifactorial Traits
4
Multiple gene hypothesis:
range of phenotypes can be
accounted for by cumulative
effect of many alleles.
10
Analysis of a quant trait: Tomato fruit
P1 ave=6oz P2 ave=18oz
11
Phenotypic Variation
Genotype and environment can interact or they can be
associated
12
Genetic Variation
Genotype-environment (G-E) association = certain
genotypes are preferentially associated with certain
environments
There is no genotypic variance in a genetically
homogeneous population sg2 = 0
When the number of genes affecting a quantitative
trait is not too large, the number, n, of genes
contributing to the trait is
n = D2/8sg2
D = difference between parental strains
13
Fig. 15.10 14
Broad-Sense Heritability
Broad-sense heritability (H2) includes all genetic
effects combined
H2 = sg2 / sp2 = sg2 / sg2 + se2
15
Heritability: Twin Studies
Twin studies are often used to assess genetic effects
on variation in a trait
19
Artificial Selection
There are limits to the improvement that can be
achieved by artificial selection:
21
Correlation Between Relatives
Genetic variation is revealed by correlations between
relatives
Covariance (Cov), the tendency for traits to vary
together, is Cov(x,y)=fi(xi - x )(yi - y )/N-1
Correlation coefficient (r) = statistical evaluation of
paired data (pairs of parents, twins, parent and
offspring)
r =Cov(x,y)/sxsy
Covariance and correlation coefficient are important in
heritability estimates
22
Correlation Between Relatives
Correlation
coefficient of a
trait between
relatives is
related to the
narrow- or
broad-sense
heritability
23
Threshold Traits: Heritability
Liability = quantitative trait that presents a genetic risk
for a threshold trait
24
Threshold Traits: Heritability
Many congenital abnormalities are inherited as
threshold traits
25
Multifactorial Disorders
Most common disorders in human families are
multifactorial
Pedigree studies of genetic polymorphisms
are used to map loci for quantitative traits
Quantitative trait locus (QTL) = gene that affects a
quantitative trait
Simple tandem repeat polymorphisms (STRPs) are
used to locate QTLs
Candidate gene = gene for which there is some a
priori basis for suspecting that it affects the trait
26