Beruflich Dokumente
Kultur Dokumente
fig 17-6
1
Testis & seminiferous tubules
fig 17-5
2
Spermatogenesis
fig 17-7
3
Structure of seminiferous tubules
fig 17-4
4
Spermatogenesis
fig 17-9
5
Spermatogenesis (notes)
6
Sertoli cell (functions)
7
Structure of spermatozoon
fig 17-8
8
Erection & ejaculation
fig 17-10
9
Erection, emission & ejaculation (notes)
Erection:
stimuli from CNS systems, penile mechanoreceptors
parasympathetic nerves (nonadrenergic noncholinergic) release NO
NO stimulates soluble guanylate cyclase in penile arteriole smooth muscle
cyclic GMP relaxes smooth muscle & increases blood flow
increased blood flow into 2 corpora cavernosa & corpus spongiosum
erection compresses venous outflow & maintains erection
Emission: (movement of seminal fluid into prostatic urethra)
sympathetic NS peristaltic contractions of vas deferens
Ejaculation:
semen entering prostatic urethra spinal reflex involving somatic NS &
skeletal muscle of perineal floor
10
Male hormonal control
fig 17-11
11
GnRH, LH, FSH (notes)
Gonadotropin releasing hormone (GnRH)
secreted by hypothalamus into hypothalamo-hypophyseal portal system
increases at puberty, ? less sensitivity to testosterone feedback
pulsatile release ~90 min pulsatile LH & FSH release
Luteinizing hormone (LH)
from anterior pituitary, stimulated by GnRH, inhibited by testosterone
acts on Leydig cells of testis testosterone release
Follicle stimulating hormone (FSH)
from anterior pituitary, stimulated by GnRH, inhibited by inhibin
acts with testosterone on Sertoli cells to promote spermatogenesis
Note: LH & FSH are produced by the same anterior pituitary cell
12
Testosterone (notes)
Source
synthesized & released by Leydig (interstitial) cells of testis
release stimulated by LH
Actions
inhibits release of GnRH & LH (not FSH)
stimulates spermatogenesis (in conjunction with FSH)
stimulates differentiation of male genitalia (in utero)
stimulates development of male 2 sexual characteristics at puberty
growth & development of internal/external genitalia
bone growth and epiphyseal plate closure, muscle development
axillary, pubic, body hair, male pattern baldness
fat distribution, laryngeal growth, sebaceous glands
behavioral effects, libido, aggression
Mechanism: steroid, androgen binding protein, transcription, translation
13
Female reproductive system
fig 17-13a
14
Female genitalia (internal)
fig 17-13b
15
Female genitalia (external)
fig 17-14
16
Oogenesis
fig 17-15
Note: asymmetric meiotic divisions
timing of mitotic & meiotic divisions
17
Oogenesis (notes)
Timing of divisions
oogonium primary oocyte (mitosis) in utero
1 oocytes begin 1st meiotic division, stop in prophase, still in utero
1 oocyte 2 oocyte + 1st polar body, (1st meiotic) before ovulation
2 oocyte ovum + 2nd polar body (2nd meiotic) after fertilization
Note: one 1 spermatocyte 4 spermatozoa; one 1 oocyte 1 ovum
Follicular attrition
oocyte surrounded by layer of granulosa cells primordial follicle
several million follicles form in utero, 2-4 x 106 remain at birth
~400,000 remain at puberty, ~400 ovulated during reproductive life
last ovulated may be 35 years older than first ovulated at puberty
18
Follicular development
fig 17-16
19
Follicular life cycle through menstrual cycle (notes)
In childhood & adult life
many primordial follicles develop to preantral follicles
day 1 day 7
10-25 preantral follicles antral follicles (larger oocyte, more layers
of granulosa cells, antrum appears, thecal cells differentiate)
around day 7
one antral follicle becomes dominant, rest degenerate
around day 14
mature follicle ~ 1.5 cm diameter, bulging through surface of ovary,
primary oocyte divides hours before ovulation occurs
day 14 day 25
corpus luteum produces estrogens, progesterone & inhibin
day 25 day 28
corpus luteum spontanteously degenerates, menstrual flow begins
20
Follicular life cycle through menstrual cycle
fig 17-17
21
Functions of granulosa & thecal cells
Granulosa cells
1. nourish the developing oocyte
2. secrete antral fluid
3. site of action of estrogens & FSH
4. contains aromatase, the enzyme which converts androgen to estrogens
5. secrete inhibin (inhibits FSH release by anterior pituitary)
Note the similarities between granulosa cells & Sertoli cells
Theca cells
1. secrete androgens which diffuse to granulosa cells
Note the similarity between theca cells & Leydig cells
22
Estrogens synthesis by granulosa & thecal cells
Note: LH & FSH are shown as acting on the wrong cells in your text book
LH FSH
fig 17-19
23
Hormonal control of the menstrual cycle
fig 17-18
24
Sequential hormonal changes during menstrual cycle
26
Hormonal interactions in the female
fig 17-20
27
Hormonal initiation of ovulation
fig 17-21
28
Endometrial changes during menstrual cycle
fig 17-22
29
Endometrial changes during menstrual cycle
Menstrual phase (first 3-5 days)
corpus luteum degenerates, estrogen & progesterone levels fall
endometrial blood vessels constrict ischemia, then relax
endometrium degenerates resulting in menstrual flow
Proliferative phase (day 5-14)
increasing estrogen levels
myometrial & endometrial growth
progesterone receptors on endometrial cells
cervix secretes abundant, clear, watery fluid
Secretory phase (day 15-28)
high progesterone levels
blood vessels, coiling of glands, glycogen in cells
cervix secretes thick sticky mucus (mucus plug)
contraction of myometrium 30
Estrogen actions
31
Progesterone actions
Note: adrenal androgens stimulate axillary & pubic hair growth, libido
32
Female sexual response
Arousal phase
initiated by physical (e.g. clitoral stimulation) or psychological stimuli
mostly directed by parasympathetic nervous system
blood flow to breasts, nipple erection
blood flow to genitalia, swelling of labia, clitoral erection
mucus secretion by vaginal epithelium
Orgasmic phase
mostly directed by sympathetic nervous system
rhythmic contractions of lower 1/3 of vaginal canal
associated physical responses ( heart rate, respiratory rate,
intensely pleasurable sensations)
34
Fertilization 2
35
Fertilization
fig 17-23
36
Implantation
zygote takes 3-4 days to reach uterus, undergoing several cell divisions
en route
cell mass (morula) floats in uterus for additional 3 days & develops into
blastocyst
note: at this time corpus luteum is functioning and the cervix secretes
the mucus plug that prevents exit of blastocyst
blastocyst implants in endometrium and begins to organize placenta
placenta begins secretion of human chorionic gonadotropin (HCG) ~3
days after implantation
HCG maintains function of corpus luteum beyond normal life (~11 days)
HCG is what is detected by pregnancy tests
clinical labs can detect HCG before the next menstrual period is due
37
Implantation of blastocyst
fig 17-24
38