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Pembimbing:
dr. Arief Tjatur P, Sp. THT-KL
Result of cumulative
Causes ? intrinsic and extrinsic
Unclear factor
Intrinsic Factor Extrinsic Factor
•Hypertension • diet
•DM
•Metabolic disease
•Other systemic disease
Quantitative
Hypotesized
Analysis
• Inclusion criteria for the presbycusis group included age of at least 60 years, a diagnosis of sensorineural hearing
loss characterized by insidious onset, bilateral symmetry, and progression of hearing loss into old age. Control
individuals were selected using medical records and otologic interview sheets. Inclusion criteria for the control
group consisted of age of at least 60 years, no clinical evidence of other ear disorders, and no description of
hearing loss in the medical record. Pure-tone audiometry had been performed between 5 months and 18 years
before death for all participants.
• We excluded individuals from both groups if they had a history of otologic diseases, such as otosclerosis or otitis
media; ototoxic drug use; head or acoustic trauma; or systemic diseases, such as diabetes mellitus or neurologic
disease
• A total of 19 temporal bones from 11 patients with presbycusis and 24 temporal bones from 15 agematched
controls met the inclusion criteria
• All temporal bones had been removed at autopsy and fixed in formalin solution. Each bone was decalcified,
embedded in celloidin, and serially sectioned in the horizontal plane at a thickness of 20 μm. Every 10th section was
stained with hematoxylin-eosin and mounted on a glass slide for assessment with light microscopy.
Spiral Modiolar Artery and Vessels in Stria Vascularis
• Morphometric measurement of the wall of the spiral modiolar artery, a main end
artery providing cochlear blood flow, was performed in perpendicular cross
sections
Statistical Analysis