TRANSPORT OF

SUBSTANCES THROUGH
THE CELL MEMBRANE

Nyoman Adiputra
 ROLE OF CELL MEMBRANE
Cell
is the basic structural unit of all
living organisms.
Membrane is a very thin envelope
that separates the cytoplasm from
the external environment.
Maintain the composition of
intracellular- and extracellular-
fluids
ROLE OF CELL MEMBRAN

EXTRACELLULAR FLUID

INTRACELLULAR FLUID
 CELL MEMBRANE FUNCTION

1) Maintaining structural integrity of the cell.

2) Controlling substances’ movement in & out
3) Regulating cell to cell interaction
4) Recognizing antigen & foreign cells
5) Interface between cytoplasm-external mil.
6) Establishing transport system for spec.mol.
7) Signaling from EC to IC events
Extra cellular fluid Intra cellular fluid
142mEq/L Na+ 10
4 mEq/L K+ 140
2.4 mEq/L Ca++ .0001
1.2 Mg++ 58
103 Cl- 4
28 HCO3- 10
4 P 75
1 SO4- 2
90 mg/dl Glucose 0-20
30 mg/dl AA 200
0.5 g/dl P-L 2-95
35 mm Hg pO2 20
46 mm Hg pCO2 50
7.4 pH 7.0
2 g/dl Protein 16
 Structure of Cell Membrane

a lipid bilayer

hydrophobicfat soluble, fatty

acid portion
hydrophilicwater soluble,
phospholipid molecule
Phospholipid bilayer, I-P protein
• Outer & inner layer of phospholipids
• Each layer: a polar head (hydrophilic), two
long non-polar fatty acid tail (hydrophobic)
• Using freeze fracture techniquescleave
into 2 leaflets: outer (E-face)
inner (P-face)
 Membrane Transport
• Two types: channel & carrier proteins
ions, small molecules.
• Two types of transport:
-passive T: -simple diffusion
-facilitated diffusion
-active T: -primary active
-secondary active
 Membrane Transport
• Diffusion: random molecular movement of
substances through intermolecular spaces in
the membrane or in combination with a
carrier protein.
• The energy from the normal kinetic motion
of matter.
MEMBRANE TRANSPORT