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Communication
Cells need to be able to
communicate to other
cells and respond to environment
changes
*For multicellular organisms, cell-
cell communication
is important
Convert signals on a
cell’s surface into cellular
response
Local and Long-Distance Signaling
Figure 11.3 (b) Cell-cell recognition. Two cells in an animal may communicate by interaction
between molecules protruding from their surfaces.
•In other cases , animal cells
Neurotransmitter
Secretory diffuses across
vesicle synapse
Local regulator
diffuses through Target cell
extracellular fluid is stimulated
(a) Paracrine signaling. A secreting cell acts (b) Synaptic signaling. A nerve cell
on nearby target cells by discharging releases neurotransmitter molecules
molecules of a local regulator (a growth into a synapse, stimulating the
factor, for example) into the extracellular target cell.
Figure 11.4 A B fluid.
Long – Distance Signaling
Both plants and animals use hormones
An Example of Cell Communication
1. Reception
2. Transduction
3. Response
Step 1 of cell signaling: Reception
Usually, two molecules are involved:
- Ligand
- Receptor
Step two of cell signaling Transduction
Step three of cell signaling: Response
Reception
A SIGNAL MOLECULE
BINDS TO A
RRECEPTOR PROTEIN
THAT, CAUSING IT TO
CHANGE SHAPE
• The cell target d by a particular chemical
signal has a receptor protein on or in the
target cell that recognizes the signal
molecule
1. G-protein-linked
2. Tyrosine kinases
3. Ion channel
G- protein –linked receptors
Receptor tyrosine kinase
Ion Channel Receptors
Transduction
• CASCADES OF MOLECULAR
INTERACTIONS RELAY
SIGNALS FROM THE
RECEPTORS TO TARGET
MOLECULES IN THE CELL
• The transduction stage of signaling is usually a
multi step pathway and these pathways amplify
the signal and provide more opportunities for
coordination and regulation.
• If some molecules in a pathway transmit a signal
to multiple molecules of the next component in
the series, the result can be large numbers of
activated molecules at the end of the pathway.
• A small number of signal molecules can produce
a large cellular response.
Signal Transduction Pathways
Pyrophosphate H2O
P Pi
Pyrophosphate
P Pi
ATP cAMP
Phosphodiesterase
H2O
H2O
cAMP AMP
• Many signal molecules trigger formation of
cAMP
First messenger
(signaling molecule
such as epinephrine)
Adenylyl
G protein cyclase
GTP
G protein-coupled
receptor
Second
ATP messenger
cAMP
Protein
kinase A
Cellular responses
Calcium ions and Inositol Triphosphate (IP3)