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Helper/Inducer(CD4)
Suppressor (CD8)
T Cell Recognition of Antigen
Recognize antigen peptide fragments bound to specialize
cell surface molecules on antigen-presenting cells (APC).
Molecules are encoded by major histocompatibility
complex
Peptides are displayed to T cells as peptide:MHC
complexes
T cell antigen receptors recognize peptide:MHC
complexes
Each MHC molecule can bind numerous different peptides
Two classes of MHC molecules
Major Histocompatibility Complex
(MHC) Gene Products
Class I
Antigen is usually endogenous (e.g. viral proteins).
CD8+ cytotoxic T lymphocytes (CTLs) recognize
antigen in association with class I MHC gene product
on APC.
Class II Molecules
Antigen is usually extracellular.
CD4+ Helper T Lymphocytes recognize antigen in
association with class II MHC gene product on APC.
Cellular Cooperation and
Antigen Recognition
Macrophages/monocytes
Plasma Cells
Antigen presentation to T
and B cells by APC
PRIMARY RESPONSE
SECONDARY RESPONSE