GROUP

MEMBER : 1. Dinda Sofiatul H. (1012016021)

2. Hasby Zein A. (1012016034)
3. Lutfika Legiana R. (1012016029)
 CITATION
Formulation and Evaluation of Sustained Release Matrix
Tablet of Rabeprazole Using Wet Granulation Techniqui

Ruqiah Khan, Md Shamin Ashraf, Muhammad Afzral, Imran

Kazmi, Mohammad Asadullah Jahangir, Rajbala Singh, Rames
Chandra, Firoz Anwar

J Pharm Bioall Sci [serial online] 2014 [cited 2016 Oct

27];6:180-4. Available from: http://
www.jpbsonline.org/text.asp?2014/6/3/180/130961
 SUMMARY

Formulation and Evaluation of Sustained

Release Matrix Tablet of Rabeprazole Using Wet
Granulation Techniqui

 Directed by:

1. Dinda Sofiatul H. (1012016021)

2. Hasby Zaen A. (1012016034)
3. Lutfika Legiana R. (1012016029)
 INTRODUCTION
 Rabeprazole is a derivative of B enzimedazole that works
by inhibiting gastric acid secretion. Rabeprazole can work
more rapidly separates the stomach acid and also more
quickly convert it to the active species to help gastric
mucin synthesis.

 Rabeprazole is known as a gastric acid pump inhibitor. It

does not have anticholinergic or histamine H2‑receptor
antagonist properties, and is acid‑labile. Once
Rabeprazole has left the stomach, absorption occurs
within 1 hour of administration.
 PURPOSE
 This study is an attempt to formulate Rabeprazole as
sustained release matrix tablet for extending its
release rate for prolong period of time thus increasing
the bioavailability
 DISCUSSION
 Rabeprazole is acid labile and hence commonly formulated as
an enteric coated tablet
 In the present study an attempt was made to formulate and evaluate
Rabeprazole tablet release matrix using wet granulation technique by
combining ingredients like HPMC-E15, Carbopol934, and sodium
carboxymethyl cellulose (CMC), so it can be evaluated or known the
physicochemical properties like rheological properties, wight variation,
thickness, hardness ,% friability and drug content.
 The most employed method to modulate the
sustained drug release is to include it in a matrix
system.

 Hydrophilic polymers have become product of choice

as an important ingredient for formulating sustained
release formulations of highly water soluble drugs.

 Sustained release matrix tablets prepared by wet

granulation technique using microcrystalline ethyl
cellulose polymer and Bees wax showed good
sustaining drug release concluding that sustained
release tablet could be successfully combined with
accurate control and prolongation of the drug release
 CONCLUSION
 Rabeprazole matrix tablet extends the release rate of
drug for a prolong period of time at least 10 hrs and
shows to increase the bioavailability and
simultaneously decrease the dosing interval as well
as dosing amount. The formulation minimizes dose
related adverse effects and cost and ultimately
improve the patient compliance and drug efficiency.