PSA – Prostatic Specific Antigen (elevation in patology of prostate) DRE – Digital rectal exam Perineum – space between the anus and scrotum in man Emesis – an act or instance of vomiting Dysuria – painful urination Polyuria – excessive urination Nocturia – excessive urination at night Hematospermia – blood in the semen Erectile dysfunction – the inability to develop or maintain an erection Prostatitis
Inflammation of the prostate gland
The most common problem in men under 50 years old Result of an infection or other various causes Classified into four categories – each with its own diagnostic and treatment approach: Prostate gland
Tubuloalveolar exocrine gland of the male
reproductive system Size of a walnut Location: anterior to the rectum (digital rectal examination - DRE) posterior to the pubic symphysis superior to the perineal membrane inferior to the bladder (urethra goes through the prostate – symptoms of prostatitis) Types of prostatitis 1. Acute bacterial prostatitis Acute bacterial infection of the prostate gland Etiology: E.coli (+ other gram – bacteria; N. gonorrhoeae and C. trachomatis) Clinical presentation: Systemic - high fever, chills, nausea, emesis Local - dysuria, urinary frequency, urinary urgency, incomplete voiding, weak stream, straining to urinate, suprapubic, perineal or rectal pain Diagnosis: Medical history + DRE (tender, enlarged) + urine and blood cultures Complications: prostatic abscess (prolonged fever and resistant to AB) – transrectal ultrasonography, CT, MRI Treatment: AB (initial – adjusted) Chronical reccurent bacterial infection of the prostate gland Types of prostatitis Ascendent urinary infection or urine reflux (chemical iritation) 2. Chronic Etiology: E.coli (and other as acute) bacterial prostatitis Clinical presentation: low-back pain, pain in the perineum, pain in the testicles or penis; urgent, frequent or painful urination, nocturia, flu-like symptoms; painful ejaculation, hematospermia Diagnosis: culturing urin, prostate fluid and semen + PSA search for cause of recurrence Treatment: AB (prolonged therapy) + alpha blockers long term low-dose th. Complications: infertility, semen abnormalities and reduced quality of life Chronic pelvic pain syndrome; the most common form Types of prostatitis Symptoms resemble those of chronic bacterial prostatitis 3. Chronic Etiology: no bacteria nonbacterial prostatitis cascade of interconnected events - overactive pain syndrome condition may affect the entire pelvic floor Clinical presentation: pelvic or perineal pain without evidence of urinary tract infection, lasting longer than 3 months; pain; voiding problems; erectile dysfunction Diagnostic: no definite diagnostic test leukocytes in prostatic fluid Treatment: AB, pain relievers, alpha blockers – depending on pattern of symptoms Types of prostatitis 4. Asymptomatic inflammatory prostatitis
Histological diagnosis with no symptoms
Diagnosis based on biopsy obtained for elevated PSA (malignancy?) or for testing for infertility Elevated PSA and white blood cells in the urine No known cause, no symptoms – no treatment