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Respon imune
Adaptive
Innate
(Specific)
(Nonspecific) o
2 line of defense
1o line of defense Protects/re-exposure
humoral
Innate Immunity Adaptive Immunity
No memory • Development
of memory
Immune System
Lymphoblasts
Regulator Effector
B lymphocytes T cells T cells
Lymphoid Cells
Innate immunity/second line of
defense Celluler Components
Interferon
Produce by virus
infected cells,
Enhance the activity
of phagocytes and
NK cells
Inhibit cell growth
Supress tumor
formation
16
COMPLEMENT
Protein yang meningkatkan
fungsi respon terhadap
infeksi/inflamasi
Classical pathway –
requires an antibody and
antigen to form a complex
Alternate pathway –
requires certain
polysacharrides on the
surface
Innate immunity/second line of defense
Humoral Components
a. Lysis of bacteria
and some viruses
b. Opsonin
c. Increase in
vascular
permeability
d. Recruitment and
activation of
phagocytic cells
Cytokines
Mediator yang
dihasilkan oleh
sel dalam reaksi
radang atau
imunologik
Innate immunity/second line of
defense Humoral Components
Biocarta.com
Innate
immunity/
second line of
defense
Humoral
Components
Adaptive immunity /third line of defense
Cellular dan Humoral Components
Three
important
aspects
1. Specificity
2. Systemic
3. Prossesses
memory
Cell-Mediated
Immunity (CMI) – T
cells
◦ Fungi, Parasites
◦ Viruses, Some cancer
cells
◦ Foreign tissue
transpalants
Antibody-Mediated
(Humoral) Immunity
(AMI) – B cells
◦ Antigens dissolved in
body fluids
◦ Extracellular pathogens
Th lymphocytes (CD4, T4)
◦ T.helper – immune respon
yang awal
Ts lymphocytes
◦ T.suppressor -
menurunkan immune
respon; # ThTs
TDH lymphocytes
◦ delayed hypersensitivity
CD4 T cells: Th1 , Th2 classification:
----------------------------------------------------------------------------------------------
CD4 T cells
Th1 cell: cytokines secreted: IL-2, IFN-g, IL-12
“inflammatory” T cells
: involved in activating
Macrophages Cell-mediated
immunity
NK cells (effector mechanisms
are cellular)
CD8 T cells
B cells
B cells
4
27
CD4 T cells: Th1 , Th2 classification:
Antibodi
• Class variation Total
Ab
IgM
Ab
IgG Ab
– 1o - IgM
– 2o - IgG, IgA or IgE
Ab Titer
1o Ag 2o Ag
34
Perubahan Ab
1o and 2o Responses
Complete antigen
◦ Immunogenecity
◦ reactivity
Hapten (incomplete antigen)
◦ Not immunogenic
◦ Antigen yang dapat melakukan reaksi spesifik Ag -
Ab, tetapi tidak dapat merangsang pembentukan
antibodi
Bahan asing (keasingan)
Ukuran molekul BM > 10,000 ( protein,
nucleoprotein, lipoprotein, glycoprotein,
polysaccharida)
Kerumitan struktur kimiawi
Konstitusi genetik
Metode pemasukan antigen
Dosis
Bagian tertentu dari molekul yang terlibat
menimbulkan ikatan antibodi (biasanya
pada permukaan) ; antigen binding site
Major Histocompatability Complex (MHC) Ag
= human leucocyte-associated antigen (HLA)
Kompleks aloantigen pada permukaan sel
manusia = Kode yg terikat pd
permukaan membran sel; khas pd
setiap individu
MHC
(Major Histocompatibility Complex)
adaptive
immunity
IMMUNE RESPONSE
Innate and adaptive immunity
Microbe
Innate immunity Adaptive immunity
B lymphocytes Antibodies
Epithelial
barriers
T lymphocytes
Phagocytes Effector T cells
Complement NK cells
Hours Days
0 6 12 1 3 5
Time after infection
IMMUNE RESPONSE
IMMUNE RESPONSE
IMMUNE RESPONSE
A
Fungsi Efektor
Antibodi
Abbas.A, Basic
Immunology, 2 ed, 2004
50
IMMUNE RESPONSE
Ag
IMMUNE RESPONSE
IL-12/1L-1 IL-6
IL-4
Th-2
Memory cell
NK cell
FC-R
Activated NK cell
Lysis cell
CYTOKINE
Abnormal cell
infection immunity
Constriction
of smooth
muscle
Respiratory tract
Respiratory tract
1. Upper
1. Upper “sinus
“sinus headache”
headache”
Allergic rhinitis
itching of
itching of eyes
eyes
tearing, sneezing,
tearing, sneezing,
watery nasal
watery nasal discharge,
discharge,
itching of
itching of nose,
nose,
throat irritation
irritation Conjunctivitis
throat
2. Lungs
2. Lungs wheezing,
wheezing, dyspnea,
dyspnea,
dry cough,
dry cough, tightness
tightness in
in chest
chest
Asthma
Gastrointestinal
Glossitis, cardiospasm
Nausea, vomitting
Irritable bowel Food allergies
Diarrhea, pruritus ani
63
Contoh immediate hypersensittivity: type I
ANAPHYLAXIS
Ragweed
73
Immune complex reaction.
Diperani oleh IgG dan IgM
Reaksi imun terbentuk antigen–antibodi
kompleks pada dinding pembuluh darah dan
cairan lainnya reaksi inflamasi
Antigen
◦ Non-Self antigens ; infeksi virus (hepatitis B),
bakteri (streptococcus dan staphylococcus), jamur (
Aspergillus), protozoa (malaria), dan protein asing
(serum).
◦ Self antigens : DNA, RNA, cytoplasm, dan jaringan.
Kompleks imun pada keadaan normal
segera disingkirkan secara efektif oleh
jaringan retikuloendotel, ada kalanya
menyebabkan reaksi hipersensitifitas
Macrophage tidak mampu menghancurkan
kompleks imun pembuluh darah,
menembus dinding pembuluh darah
diginjal dan jantung.
Termasuk tipe III
Systemic lupus
erythematous (SLE)
Erythema nodusum
Rheumatoid arthritis
Polyarteritis nodosa
Arthus reaction
Serum sickness
CAUSES MECHANISM PATHOPHYSIOLOGY CLINICAL
EXAMPLES
Antigen
Glomerulo-
Autoantibodies Antigen and Deposits on vessel walls Tissue nephritis
Drugs antibody form or basement membrane destruction Vasculitis
Serum an immune
Chemicals complex Inflammation Arthus reaction
Foreign antigen
Bacteria Rheumatoid
Virus diseases
Serum sickness
79
Synonym: cell-mediated hypersensitivity
reaction, delayed hypersensitivity reaction.
Yang berperan T cell (CD4–TH1), makrophag
Kontak awal; antigen Macrophages T
sel (CD4-T sel) T memori sel.
Kontak kedua; antigen T sel memori
perubahan bentuk lymphoblasts dan T sel
memori (CD4–TH1-T lymphocytes)
delayed immunity effector cells.
pelepasan macrophage cytokines:
◦ MAF ( macrophage-activating faktor)
◦ MCF ( faktor macrophage-chemotactic);
◦ MIF ( migration-inhibitory faktor)
◦ MFF ( macrophage faktor peleburan)
CD8-T sel cytotoxic dan macrophages
menghancurkan sel target dengan
mekanisme
◦ Apoptosis
◦ Proteolysis
Reaksi tipe IV pada umumnya timbul lebih
dari 12 jam
Pembentukan antibodi diperlukan adanya
sensitisasi yang lama kira-kira 14 hari
Yang termasuk tipe IV
Contact allergy
Tuberculin reaction (mantoux tes)
Granulomatous hypersensitivity reaction.
CAUSES MECHANISM PATHOPHYSIOLOGY CLINICAL
EXAMPLES
Antigen
Release of : Contact
Lymphokines dermatitis
Tuberculin Sensitized Injury and
Migration inhibition Graft vs host
Poison Ivy Lymphocyte destruction of
factor reactions
Chemical reacts with target organ
Interferon Viral infection
Fungi antigen
Killer cells Autoallergic
Transplanted
Transfer factor disease
organs
Virus
87