Moldavia Lu Pard in I

GUNA INTERNATIONAL COURSE
_______________________
PHYSIOLOGICAL REGULATING MEDICINE
The mechanism of action in the drainage therapy of GunaLympho,

Matrix, Bowel, Kidney and Liver and WHY and in WHICH cases
those medicines should be administrated
CHISINAU
May 19, 2018
Maurizio Lupardini, Specialist in Psychiatry 1
Theseslides are based on the presenter’s studies on
Low Dose Medicine.
The information presentedhereisnottobeconsidered a

prescription and no medical or
legalresponsibilityformisuseof the information
presentedwillbeaccepted. This information isfor
educational purposesforlicensedhealth care
professionalswithintheir scope ofpractice.
2
© Dipartimento Scientifico Guna S.p.a.
The pathwaywe’ll take
duringthislecture
Bases of Low Dose
Pharmacology
Action mechanism of
low doses and use of
low dose Focus -3
signalingmolecules In whichcaseswe use
some kind of drugs
Focus -1 Focus -2
Fundemantal of P.N.E.I. Drainage Whywe use some kind of
FIRST THERAPY (Why) drugs
LOW DOSE PHARMACOLOGY
A newpharmacology
Why choose it?

1) 100% clinical safety
2) Long term treatments
3) Effectiveness
4) Allows an overlapping approach
5) Fills the therapeutic vacuum(s)
6) Affordable cost
Low Dose Pharmacology Bag of Tools
SINGLE COMPONENT MULTICOMPONENT

BASED MEDICINES MULTITARGET
(SINGLE CYTOKINES) BASED
(SINGLE GROWTH FACTORS)
MEDICINES
LOW DOSE PARMACOLOGY
A new pharmacological concept: one biotherapeutic
medicine blending synergistic ingredients from
Conventional Medicine and Complementary Alternative
Medicine to achieve a positive clinical outcome.
Molecular Biology Homeopathic Science
NEUROPEPTIDES, PLANTS,
CYTOKINES, MINERALS,
HORMONES, ANIMAL DERIVATIVES.
GROWTH FACTORS.
PhysiologicalRegulating Medicine
(PRM)
TWO EXAMPLES
TO START
7
RECURRANT URINARY TRACT INFECTIONS
•CITOMIX: 10 granules a week •GUNA-KIDNEY: 20 dropstwice a

for 6-8 weeks. Repeat the dayfor 2-4 months
cycleafter 45 days
•EUBIOFLOR 20 dropstwicea
dayfor2-4 months
•GUNA-BOWEL: 20 dropstwice
a dayfor 2-4 months
8
GUNA-KIDNEY Solidago*
Rubia*
Equisetum*
•Support to the metabolism of the Ononis*
renal cell. Ortosiphon*
Sarsaparilla*
Mouse ear hawkweed*
Plantago**
Pareira**
Ac. Succinicum Acidum nitricum***
ho rem
Cl eop die
Kalium nitricum***
ts
m e
Quihynidron
as a s
ys
si thi
Methileneblue
al
c
t
Ca •Activation of the excretoric
funcion of kidney and renal
c
ducts. Diuretic action*.
•Anti-inflammatory action on
•Stimulation of the the renal ducts**.
Su pa
s
homologous organs
pr
•Antidegenerative action on
de
is ra
e
function. the genital-urinary
so
or tio
No
apparatus***.
ga ns
•Antidegenerative
n
action on the
homologous organs.
•Renal insufficiency
forms on infective
basis
Kidney
Colibacillinum •Activation of the
Ureter specific immune
Proteus
Urinary bladder response in case of
cystitis
EUBIOFLOR 1
IMMUNODEFICIENCY
ETIOPATHOGENESIS INTESTINAL
OF INTESTINAL FERMENTATION
DYSBIOSIS AND PUTREFACTION
ALTERATION OF
INTESTINAL MICROFLORA REDUCTION OF INTESTINAL
DRAINAGE

EUBIOFLOR 1 •VACCINIUM MYRTILLUS 4X
•PANCREAS SUIS 12X
•PINK TRUMPET TREE 4X
•MERCURYAMALGAM 6/12/30D200X
•CAT’S CLAW 4X
•INDOLUM 6/12/30X
•OKOUBAKA 6X
•SCATOLUM 6/12/30X
•AETHUSA CYNAPIUM 6X
•CARBO VEGETABILIS 6X
IMMUNOSTIMULATION
ANTI-FERMENTATION E ANTI-
PUTREFACTION ACTION ON THE
INTESTINE
EUBIOFLOR 1
EUBIOFLOR 1
RECOVERY OF
INTESTINAL BALANCE INTESTINAL
DRAINAGE
•COLIBACILLINUM 6/12/30X •COLON PORCINE 6/12/30X

•PROTEUS 6/12/30X •HEPAR SUIS 12X
•CANDIDA ALBICANS 6/12/30X •GAL BLADDER PORCINE 6X
•NUX VOMICA 6X
•VERATRUM ALBUM 6X
•ALTHAEA OFFICINALIS 4X
•CARDUUS MARIANUS 4X
•TARAXACUM 4X
GUNA BOWEL Alumina 6/8X
Bryonia 6/8X
•Protection
Protection of
of epithelia*.
epithelia*. Rectum porc. 6/12/30X
• Anti-putrefaction Colon, porc. 6/12/30X
Anti-putrefaction and
and anti-
anti-
dysbiosis
dysbiosis action
action **.
**. Nux vomica 6/8X
e
Vitamin B1, B3 e B5
ti v
Vitamin D* 2X
on a
In imu
ti er
st
• Stimulation of
te la
ac e n
Skatolum** 6/10X intestinal function in
st tio
eg
in n
general.
al
id
nt
• Stimulation of
A
peristalsis.
• Regulation of Consitutional • Decrease of rectal
Laxative atony episodes.
constitutional proneness rebalance action
to drainage insufficiency
of the digestive tract.
Hepatic Aloe 2X
Kali carb. 6/8/12X stimulation
Rhamnus 2X
Natrum carb. 6/8/12X
Rheum 2X
•Laxative action to
Carduus 2X treat irritation
• Reduction of portal stasis.
Chelidonium 2X episodes of
•Choleretic and cholagogue intestinal mucosa.
action. Collinsonia 2X
Taraxacum off. 2X
CYTOMIX
•MOUNTAIN CRANBERRY 3X •LYMPHATIC VESSEL 4C
•ANANASSA SATIVA 3X •MEDULLA OSSIS SUIS 4C
•HYDROCOTYLE ASIAT. 3X •THYMUS GLAND 4C
ORGAN
PREPARATIONS
HOMEOPATHIC “SUIS”
ANTISEPTIC ACTION
REMEDIES STIMULATION OF
(Mountain cranberry), IMMUNOCOMPETENT
AL LY
ANTIINFLAMMATORY
T HIC ES TISSUES
A I N
(Ananassa sativa),
M EOP CYTOK
RES STIMULATING HO TED
U
(Hydrocotyle asiatica) DIL
•GCSF 4/9/15 C
TRIGGER OF •IL1 5C •IL4 4C STIMULATION
IMMUNE OF B (IL4), AND
•INF gamma 4C •IL2 5C
RESPONSE T, B, NK (IL2).
•IL6 7/9/15C
COLD
•CITOMIX: 10 granules a week •GUNA-FLU: 1 dose a week for 6-

for 6-8 weeks. Repeat the 8 weeks. Repeat the cycleafter
cycleafter 45 days 45 days
GUNA THROAT SPRAY: 1 spray
•IL 2 4CH: 20 dropstwice a day on the affectedareas at
(Differentiation T lymphocite, B leastthreetimes a day.
e NK)
•GUNA-MATRIX: 20
dropstwice a dayfor 2-4
months
14
CYTOMIX
•MOUNTAIN CRANBERRY 3X •LYMPHATIC VESSEL 4C
•ANANASSA SATIVA 3X •MEDULLA OSSIS SUIS 4C
•HYDROCOTYLE ASIAT. 3X •THYMUS GLAND 4C
ORGAN
PREPARATIONS
HOMEOPATHIC “SUIS”
ANTISEPTIC ACTION REMEDIES STIMULATION OF
(Mountain cranberry), L LY IMMUNOCOMPETENT
ICA
ANTIINFLAMMATORY AT H I NES TISSUES
(Ananassa sativa), RES M EOP CYTOK
STIMULATING HO TED
U
(Hydrocotyle asiatica) DIL
•GCSF 4/9/15 C
TRIGGER OF •IL1 5C •IL4 4C STIMULATION
IMMUNE OF B (IL4), AND
•INF gamma 4C •IL2 5C
RESPONSE T, B, NK (IL2).
•IL6 7/9/15C
GUNA-FLU
IMMUNESTIMULATION CORE
Prevention and
treatment of flu
and cold
syndromes
SYMPTOMATIC CORE

IMMUNESTIMULATION CORE
Subnucleus
SINERGISM of Specific
Immunity
NK Cells
ITY
Tc Lymphocites
R
TAN
ME
LE
MP
CO
Subnucleus
of Aspecific
Immunity
Gamma-interferon
SYMPTOMATIC REMEDIES CORE
Influential myalgia.
Antipyretic activity due to Remedy for the initial
heat dispersion phases of the acute fever
(convection). reaction, with quick,
violent and sudden onset.
CUPRUM 3C Anas barbariae 200K

Influenzinum 9C ACONITUM 5C
Vincetoxicum 5C
ECHINACEA 3C
BELLADONNA 5C
Anti-inflammatory
and antiseptic Acute local
action. inflammations, in the
initial phase. Evolution of
Aconitum
symptomatology.
Bryonia 6/8X
•Protection
Protection of
of epithelia*.
and anti-
anti-
dysbiosis
dysbiosis action
action **.
**. Nux vomica 6/8X
e
Vitamin B1, B3 e B5
ti v
Vitamin D* 2X
on a
In imu
ti er
st
• Stimulation of
te la
ac e n
st tio
eg
in n
general.
al
id
nt
• Stimulation of
A
peristalsis.
Hepatic Aloe 2X
Rhamnus 2X
Rheum 2X
Taraxacum off. 2X
A pharmacological heresy?
Can LOW DOSE cytokines, hormones,
neuropeptides and growth factors be
effective (under the minimal
pharmacological effective dose) on
biological systems?
LOW DOSE SIGNALING MOLECULES
THE GREAT INNOVATION

Signalaing Molecules
The Foundation for LDM
SIGNALING MOLECULES are

MESSENGERS, THE WORDS used by
the 3 homeostatic control systems to
speak each other …and to lead the
body physiology.
23
SIGNALING MOLECULES AND DISEASES
DISEASES CAN BE CONSIDERED
AS EXPRESSIONS,
CONSEQUENCES OF CHANGED
CONCENTRATION OF
SIGNALING MOLECULES

DISEASE
HYPER-CONCENTRATION
10-6
ill
ili
te r
HEALTH il iter
ill
4C – X6
m m
s/ s/
m m
m
g ra ram
ico PHYSIOLOGICAL CONCENTRATION n og
p na
10-15
HYPO-CONCENTRATION
DISEASE
C O P E Cytokines & Cells Online Pathfinder Encyclopedia Version 26.7 (Spring 2011 Edition) © Dipartimento Scientifico Guna S.p.a.
DEFINITIONS
g(gram)= 1
10 -1 = 0.1
10 -2 = 0.01
mg (milligram)= 10 -3 = 0.001
μg (microgram)=10 -6 = 0.000001
ng (nanogram)= 10 -9 = 0.000000001
pcg(picogram)= 10 -12 = 0.000000000001
fg(fentogram)= 10 -15 = 0.000000000000001

Why a DOSE of a
signaling molecule
must be LOW?

TRANS-MEMBRANE RECEPTORS
Up- and Down-Regulation
TNF
Soluble TNF receptor
Cell-surface receptor
Cell activation
UP- AND DOWN-REGULATION
The membrane receptorplays a KEY role.
“I love you”
ONLY physiological concentrations are able to
activate or reactivate the membrane receptors and
consequently, stimulate the physiological function
of a target cell.
- Akahoshi T et al. Interleukin 1 stimulates its own receptor expression on human fibroblasts through the endogenous
production of prostaglandin(s). J Clin Invest. 1988 Oct;82(4):1219-24
- Samanta AK et al. Interleukin 8 (monocyte-derived neutrophil chemotactic factor) dynamically regulates its own receptor
expression on human neutrophils. J Biol Chem. 1990 Jan 5;265(1):183-9.
29
How low must a
low dose be to be
effective (and safe)?

The concentration of Guna
Sequential Kinetic Activated
(SKA) cytokines is in the rage of
pg-fg/ml

EFFECTS OF DIFFERENT DOSES OF CYTOKINES
TM
TOXIC
TOXIC CONCENTRATION EFFECT
10-3 mg/ml
PHARMACOLOGICAL EFFECTS
PHARMACOLOGICAL CONCENTRATION SIDE EFFECTS
mcg-ng/ml
10-6 MINIMAL EFFECTIVE PHARMACOLOGICAL DOSE
WITH SKA: WITHOUT SKA:

PHYSIOLOGICAL PHYSIOLOGICAL CONCENTRATION NO BIOLOGICAL
EFFECTS EFFECTS
ng-pcg-fg/ml
10-15 MINIMAL EFFECTIVE PHYSIOLOGICAL DOSE
32
Itis a sophisticated DRUG DELIVERY
SYSTEM
abletomakemolecularconcentrationse
ffectiveevenbelow the minimal
effective dose.
Bulletin of Experimental Biology and Medicine, Vol. 154, No. 1, November, 2012

PRINCIPLE #1 OF LOW DOSE MEDICINE
Every disease is a
SYSTEMIC disease.
34
HOMEOSTATICControlSystems
P CENTRAL NERVOUS SYSTEM

&
N
AUTONOMIC SYSTEM
E ENDOCRINE SYSTEM
I IMMUNE SYSTEM
Ader, R., Psychoneuroimmunology, IV edition, vol. 1 e 2, Academic Press, Amsterdam 2007.

It is the classical text on the matter, pubblished for the first time in 1981. © Dipartimento Scientifico Guna S.p.a.
DISEASE
P •T°36°-37°
N •pH
HOMEOSTASIS
7-7.5
E •O2 98%
•Glycemia 60 -110 mg/dl
I •Iron 60 -160 mcg/dl male; 20 -140 mcg/dl female
DISEASE © Dipartimento Scientifico Guna S.p.a.

HOMEOSTATIC ControlSystems and
bi-directional cross-talk
P CENTRAL NERVOUS SYSTEM

&
N
AUTONOMIC SYSTEM
E ENDOCRINE SYSTEM
I IMMUNE SYSTEM
Ader, R., Psychoneuroimmunology, IV edition, vol. 1 e 2, Academic Press, Amsterdam 2007.

It is the classical text on the matter, pubblished for the first time in 1981. © Dipartimento Scientifico Guna S.p.a.
CIRCULARITY

CELLS TALK TOGETHER:
…CELLS TALK
THE TO
INTERCELLULAR
EACH OTHER CROSS-TALK…

Lotti T et al. International Journal of Dermatology 2002, 41,
311–318

The GUT MICROBIOTA
Under normal conditions,
the G.I. tract provides a
stable habitat for
commensal bacteria that
supports its structural and
functional integrity also
via a physiological,
controlled
inflammation
i.e. immunotolerance
Collins S M, Bercik P. The Relationship Between Intestinal Microbiota and the Central Nervous
System in Normal Gastrointestinal Function and Disease. GASTROENTEROLOGY 2009;136:2003–2014

Gut is the main target of a
wide range of inflammatory
triggers. In particular:
• Food
• Stress
• Drugs
• Autoimmune mechanisms
47
Figure 1. Different levels of stomach inflammation found (clockwise from top left): nil (from
a non-GM-fed pig, number B41), mild (from a non-GM-fed pig, number B15), moderate
(from a GM-fed pig, number C34) and severe (from a GM-fed pig, number D22).
A long-term toxicology study on pigs fed a combined genetically modified (GM) soy and GM maize diet Judy A. Carman1,2*, Howard R. Vlieger3, Larry J. Ver Steeg4, Verlyn E.
Sneller3, Garth W. Robinson5**, Catherine A. Clinch-Jones1, Julie I. Haynes6, John W. Edwards2 - Journal of Organic Systems, 8(1), 2013
1 Institute of Health and Environmental Research, Kensington Park, SA, Australia.
2 Health and the Environment, School of the Environment, Flinders University, Bedford - Park, SA, Australia.
3 Verity Farms, Maurice, Iowa, USA.
4 Ana-Tech, Monroe, Wisconsin, USA.
5 Sioux Center Veterinary Clinic, Sioux Center, Iowa, USA.
6 School of Medical Sciences, University of Adelaide, Adelaide, SA, Australia.
* Email: judycarman@ozemail.com.au, judy.carman@flinders.edu.au.
** Present: Robinson Veterinary Services PC, Sioux Centre, Iowa, USA.
Influence of stress on gutinflammation
A change in G.I. physiology
provides an altered habitat
that in turn supports a
different microbiota.
This could be a basis for
maintaining a state of
G.I. dysfunction
after perturbation of the
microbiota; it could
also explain the development
and persistence of dysbiosis
in conditions in which there
is a primary disturbance of
G.I. physiology.
Collins S M, Bercik P. The Relationship Between Intestinal Microbiota and the Central Nervous
System in Normal Gastrointestinal Function and Disease. GASTROENTEROLOGY 2009;136:2003–2014

JUNCTIONAL SYSTEMS
S Ménard, N Multiple facets of intestinal permeability and epithelial handling of dietary antigens. Mucosal Immunology 2010
DOWN-TOP PATHOGENESIS
The Gut Centrality
1 TAKE HOME
st
TAKE CARE OF YOUR

GUT
ALWAYS!
52
Just a flash
Always protect the
homeostasis of the gut
microbiome!
Think of:
EUBIOFLOR
(20 drops twice a day for 2 months or more)
53
EUBIOFLOR •VACCINIUM MYRTILLUS 4X
•PANCREAS SUIS 12X
•PINK TRUMPET TREE 4X
•MERCURYAMALGAM 6/12/30D200X
•CAT’S CLAW 4X
•INDOLUM 6/12/30X
•OKOUBAKA 6X
•SCATOLUM 6/12/30X
•AETHUSA CYNAPIUM 6X
•CARBO VEGETABILIS 6X
IMMUNOSTIMULATION
ANTI-FERMENTATION AND
ANTI-PUTREFACTION ACTION
EUBIOFLOR 1 ON THE INTESTINE
EUBIOFLOR 1
RECOVERY OF
INTESTINAL BALANCE INTESTINAL
DRAINAGE
•COLIBACILLINUM 6/12/30X •COLON PORCINE 6/12/30X

•PROTEUS 6/12/30X •HEPAR SUIS 12X
•CANDIDA ALBICANS 6/12/30X •GAL BLADDER PORCINE 6X
•NUX VOMICA 6X
•VERATRUM ALBUM 6X
•ALTHAEA OFFICINALIS 4X
•CARDUUS MARIANUS 4X
•TARAXACUM 4X
Just a flash
Always protect the integrity of
the mucosal layer of the gut!
Think of:
GUNA-BOWEL
(20 drosp twice a day for 2 months or more)
55
Bryonia 6/8X
•Protection
Protection of
of epithelium*.
epithelium*. Nux vomica 6/8X
• Anti-putrefaction
and anti-
anti- Vit. B1 4X, Vit. B3 2X
dysbiosis
dysbiosis action
action **.
**. Vit. B5 2X
Colon, porc. 6/12/30X
Vitamin D* 2X Rectum porc. 6/12/30X
n ive
In imu
st
ac ner i-
te la
tio at
t
st tio
ge An
Skatolum** 6/10X
in n
• Stimulation of
al
intestinal function in
de
general.
• Regulation of • Stimulation of
Consitutional Laxative peristalsis.
constitutional proneness
rebalance action •Decrease of rectal
atony episodes.
Hepatic Aloe 2X
Rhamnus 2X
Rheum 2X
Carduus 2X* •Laxative action to

• Reduction of portal stasis*. treat episodes of
Collinsonia 2X* irritation of intestinal
•Choleretic and cholagogue
action**. Chelidonium 2X** mucosa.
Taraxacum off. 2X** 56

VITAMIN D: ANOTHER KEY REGULATOR OF
TIGHT JUNCTION FUNCTIONS
“…vitamin D deficiency is a critical factor in the pathology of

varieties of cancer as well as inflammatory bowel diseases (IBD),
bacterial infection, autoimmune diseases, diabetes, osteoarthritis,
periodontal disease, skin disorders and more”
Zhang YG, Wu S, Sun J. Vitamin D, Vitamin D Receptor, and Tissue Barriers. Tissue Barriers. 2013 Jan 1;1(1).
VITAMIN D3 TREATMENT PROMOTES
THE TRANSLOCATION OF ZO-1 TO THE PLASMA MEMBRANE
VITAMIN D
ZO-1
Occludin
VDR Claudin -12
Claudin -2
TJ
VDR
TIGHT JUNCTION
STABILIZATION
GENE EXPRESSION
Zhang YG, Wu S, Sun J. Vitamin D, Vitamin D Receptor, and Tissue Barriers. Tissue Barriers. 2013 Jan 1;1(1).
The GOALS of Low Dose Medicine
• TO CURE THE HUMAN BEING

AND NOT JUST THE DISEASE;
• TO ACT ON THE CAUSES AND

NOT JUST ON THE SYMPTOMS;
• TO CONSIDER THE HUMAN

BEING AS A WHOLE MIND-BODY
AND IN HIS INDIVIDUALITY.

The therapeutic approach to patient according
to Low Dose Medicine
P.N.E.I. SYMPTOM
REBALANCING TREATMENT
DRAINAGE AND DETOXIFICATION

PRINCIPLE #2 OF LOW DOSE MEDICINE
A good DRAINAGE is a
half of a good therapy.
61
TBDT
TotalMental
BodyDetoxificationTherapy

Importance of the Connective Tissue
(MATRIX) in the Physiological Regulation
Medicine
With the Physiological Regulation Medicine (Guna

Method) we overcome the matrix static concept.
The Connective Tissue is seen as:
MORPHO-FUNCTIONAL UNITY
•CAPILLAR
•MATRIX
•MEMBRANE RECEPTOR
63
THE EXTRA-CELLULAR MATRIX
Morpho-functional unity: vessel-matrix-
membrane receptor
MATRIX
VESSELS
MEMBRANE
RECEPTORS

Importanceof the Connectivetissue in the
PHYSIOLOGICAL REGULATION MEDICINE. 1
The Connectivetissueis the true“System ofbasalRegulation”:all
the changes in ourexternal and internalenvironmentinfluence,
through the fundamentalsubstance, the cellularmechanisms.
Through the connectivalmatrixtakesplace the
communicationbetweencells and externalenvironment: hugeis
the quantityof information that can bestored in the matrix and
transmittedto the cellsasinstructionsfortheirphysiologicactivity.
The neurovegetative endingsbranch out in the matrix; it’s
herethat, throughneural and endocrine substances, and
cytokines, move the psycho-neuro-endocrine-immunologic
information which coordinate and controlitsactivitybymeansof
the bindingwith the cellreceptors.
A stressorsaccumulation in thisplacerepresents the

potential trigger for the beginning and the
progressionof a pathologicprocess.
65
Importanceof the Connectivetissue in the
PHYSIOLOGICAL REGULATION MEDICINE. 2
The membrane receptorplays a veryimportantrole.

It’s notonlyimportant the quantityof “ligand” (hormone, cytokine
or neurotransmittor), but the receptor’s
abilitytobindthesemolecules, i.e. theiraffinity.
Goodexamples are the leptininthe obesity, the insulinin the type 2
diabetes (non-insulin-dependent) or the TNF-alpha or IL1in the
chronicphlogosis.
Only the physiologicconcentrationisabletoactivate or

reactivatethe membrane receptorsand, consequently,
the right functionof a target cell.
66
©Dipartimento Scientifico Guna S.p.a.
EXOGENOUS OR
ENDOGENOUS STRESSOR
SYSTEM MAN
HOMEOSTASIS
ADAPTATION
ALTERATION
PATHOLOGIC PROCESS HEALING
“HYPER” OR “HYPO” STRESSOR STORAGE (MATRIX

COMPENSATIVE PRODUCTION AND CELL INTOXICATION
OF HORMONES, STRESSOR)
INTERLEUKINES,
NEUROTRANSMITTERS
ALTERATION OF THE PNEI

CHRONICIZATION 67
BALANCE
PATHOLOGIC PROCESS
“HYPER” OR “HYPO” COMPENSATIVE

PRODUCTION OF HORMONES, STRESSOR STORAGE (MATRIX AND CELL
INTERLEUKINES, INTOXICATION STRESSOR)
NEUROTRANSMITTERS
Deposit of toxins at the level of the interstitial space

ALTERATION OF THE PNEI of the loose pericellular fibrillar connective tissue
BALANCE
COMPENSATIVE PRODUCTION INTOXICATED MATRIX NO LONGER

CAUSES
1. carries out its defense (structural or filtering);
1. Production of ILl (IL1, TNF alfa,
2. allow adequate passage of oxigen and nutriens from
etc.), Homones and neuropeptides
capillaries to the cell (shift aerobic/a aerobic
(i.e. prolacin or cortisol, etc.);
metabolism);
2. Alteration of remaining too long
3. allow the passage of information molecules
and in excessive quantities in the
(hormones, neuropeptides, interleukine;
matrix medium;
4. is able to carry outCHRONICIZATION
its immunological defense 68
3. A non-response process of the target
functions thanks to the inflammatory process;
cells by closing down their
membrane receptors (down – 5. The RES functions residing in its and its histological
regulation) – chronic form of framework change (fibrosis to scleroris)
disease.
PATHOLOGIC PROCESS
“HYPER” OR “HYPO”
COMPENSATIVE PRODUCTION OF STRESSOR STORAGE (MATRIX AND CELL
HORMONES, INTERLEUKINES, INTOXICATION STRESSOR)
NEUROTRANSMITTERS
Deposit of toxins at the level of the interstitial space

ALTERATION OF THE PNEI of the loose pericellular fibrillar connective tissue
BALANCE
INTOXICATED MATRIX NO LONGER
COMPENSATIVE PRODUCTION
1. carries out its defense (structural or filtering);
CAUSES
2. allow adequate passage of oxigen and nutriens from
Production of Il (IL1, TNF alfa, etc.),
capillaries to the cell (shift aerobic/a aerobic
Homones and neuropeptides ( i.e.
metabolism);
prolacin or cortisol, etc.);
3. allow the passage of information molecules
Alteration of remaining too long and in
(hormones, neuropeptides, interleukine;
excessive quantities in the matrix
medium; 4. is able to carry outCHRONICIZATION
its immunological defense 69
functions thanks to the inflammatory process;
A non-response process of the target
cells by closing down their membrane 5. The RES functions residing in its and its histological
receptors (down –regulation) – chronic framework change (fibrosis to scleroris)
form of disease.
Takesintoconsideration the human body

asanOPEN SYSTEMinhomeostaticbalance.
The elementsthat alter the homeostaticbalance are
EXOGENOUS STRESSORS (LIFE EVENTS,
environmentalpollutingsubstances, fine food, allergenes,
virus, bacteria, parasites, artificialcolouring, additives,
preservatives, syntheticdrugs, etc.) and ENDOGENOUS
STRESSORS (LIFE EVENTS, intermediate metabolites,
finalcatabolytes, biologicalmolecules - cytokines,
hormones, neurotransmitters – produced in excess or
deficiency).
70
To every alteration in the homeostatic balance
corresponds a body reaction having positive
(healing process) or negative (pathological
process) results.
Both the processes are the expression of the
organism ability to adapt.
In case of pathological process, the adaptation
causes, on one hand, the stressor setting aside at
the matrix or cell level, on the other hand, the
altered production of biological molecules and the
inefficiency deterioration in recovering the
physiological homeostasis.
71
Action Drugs
CELL CELL
DRAINAGE •GUNA-CELL
MATRIX
MATRIX
DRAINAGE •GUNA-MATRIX
•GUNA-LYMPHO
EMUNCTORIES EMUNCTORIAL •GUNA-LIVER

DRAINAGE
•GUNA-KIDNEY
•GUNA-BOWEL
72
2NDINTOXICATION STAGE
1 INTOXICATION STAGE
ST
3RD INTOXICATION STAGE
Signs of the function

Phlogosis and reduction: hypertrophy Alteration signs: structure
hyperfunction signs and hyperplasy and function lost
GUNA-LYMPHO
GUNA-LYMPHO +
GUNA-LYMPHO + GUNA-MATRIX
GUNA-MATRIX +
GUNA-CELL
DRAINAGE ON A PARALLEL ORGAN
Good hepatic Good intestinal Good renal

functionality: functionality: functionality:
GUNA-LIVER GUNA-BOWEL GUNA-KIDNEY73
DETOXIFICATION AND DRAINAGE THERAPY
Extra-
cellularmatrix
Lymphatic
circulation
Kidneysexcr Bowelexcre
etion tion
Liverexcreti
on
THE EXTRA-CELLULAR MATRIX
Morpho-functional unity: vessel-matrix-
membrane receptor
MATRIX
VESSELS
MEMBRANE
RECEPTORS

GUNA-MATRIX •Ac. D-L malicum 6X*
•Natrium oxal. 6X*
•Pyrogenium 12X*
•Fucus 3X* •Natrium pyruv. 6X*
•Tyrosine 2X** •NADID 6X*
•Phenilalanine 2X** •Trychinoil 6X*
•Histidine 2X** •Vit. C 2X*
•Ac. L(+) lacticum3X**
•Deactivation
Deactivation (through
(through M
e •Stimulation of
inflammation)
inflammation) and
and su tab
xin tion
mitochondrial energy
neutralization
neutralization of the
of the o
T liza pp oli production.*
impregnated toxins*. or c
impregnated toxins*. ra t
ut •Matrix acidification
•Synergistic
Synergistic action
action with
with ne (promoting connective tissue
Fucus
Fucus and
and thyroid
thyroid hormone
hormone reactivity).**
activating
activating the
the Action against Matrix
sympatheticotonic
sympatheticotonic nervous
nervous liquification •IL 6 4C*
toxin
system**.
system**. •DHEA 6X*
impregnation and drainage
•Pyrogenium 12X*
•Hyaluronidase 6X* •Conjunctive Tissue 6X*
Lymphatic •Tyrosine 2X**
•Thuja 6/8/12/30/200X**
•Natrium sulfuricum 6/8/12/30/200X **
drainage •Phenilalanine 2X**
•Prolactine 6X*** •Histidine 2X**
•DHEA 6X*** •Prolactine 6X***
•Matrix hydrolysis* •Increase of Fundamental

Substance kinetics (protein
•Action against the constitutional hydrolysis, hyper-ionicity,
tendency to impregnation of the histaminic activity, increased
matrix with toxins and to the •Lymphatic vessel 6X temperature) and matrix
development of Dysmetabolic turnover rate.*
Mesenchymopathy
(psychcosis).** •Inactive
Inactive toxins
toxins mobilized
mobilized •Sympatheticotonic
towards
towards the
the lymphatic
lymphatic circle
circle stimulation.**
•Matrix solubilization.*** for 76
for drainage
drainage •Vagotonic inhibition.***
THE CORE OF
GUNA-MATRIX
•Pyrogenium 12X*
•IL-6 4C*
•Hyaluronidase 6X
•Induce the SOL phase of the ECM fundamental

substance
* Silacci P. et al. Interleukin (IL)-6 and Its Soluble Receptor Induce TIMP-1 Expression in Synoviocytes and
Chondrocytes, and Block IL-1-induced Collagenolytic Activity. J Biol Chem. 1998, 273, 13625-13629

Pyrogenium D6*PYROGENIUM
= Gram++ and Gram--= LPS
TLRs
DC
IL- 12
Th1 response
IL- 1 IL- 1
MMP2 and 3 (Draining)

activation micro-inflammation
INDUCTION OF THE PHYSIOLOGICAL SOL PHASE OF THE ECM

* Silacci P. et al. Interleukin (IL)-6 and Its Soluble Receptor Induce TIMP-1 Expression in Synoviocytes and Chondrocytes, and Block IL-1-induced Collagenolytic
Activity. J Biol Chem. 1998, 273, 13625-13629
•Pyrogenium 12X*
•Deactivation
(through M
e •Stimulation of
inflammation)
inflammation) and
and su tab
xin tion
neutralization
of the o
•Synergistic
Synergistic action
action with
Fucus
Fucus and
and thyroid
thyroid hormone
activating
activating the
sympatheticotonic
toxin
system**.
•Pyrogenium 12X*
•Thuja 6/8/12/30/200X**
•Increase of Fundamental
•Matrix hydrolysis*
Mesenchymopathy
•Inactive
Inactive toxins
toxins mobilized
(psychcosis).**
towards
towards the
the lymphatic
lymphatic circle
for drainage
Thuja IMMUNOMODULATING
occidentalis L. EFFECT
POLY-SACCHARIDIC FRACTION
• IL-1 beta
• IL-6 ECM
• TNF-beta Solubilization
• Offergeld R, et al. Mitogenic activity of high molecular polysaccharide fractions isolated from the cuppressaceaeThujaoccidentalis L.
enhanced cytokine-production by thyapolysaccharide, g-fraction (TPSg). Leukemia. 1992;6 Suppl 3:189S-191S.
• Sunila ES, et al. Effect of Thujaoccidentalis and its polysaccharide on cell-mediated immune responses and cytokine levels of metastatic
tumor-bearing animals. Pharm Biol. 2011;49(10):1065-73.

•Pyrogenium 12X*
•Deactivation
(through M
e •Stimulation of
inflammation)
inflammation) and
and su tab
xin tion
neutralization
of the o
•Synergistic
Synergistic action
action with
Fucus
Fucus and
and thyroid
thyroid hormone
activating
activating the
sympatheticotonic
toxin
system**.
•Pyrogenium 12X*
•Thuja 6/8/12/30/200X**
Mesenchymopathy
•Inactive
Inactive toxins
toxins mobilized
(psychcosis).**
towards
towards the
the lymphatic
lymphatic circle
for drainage
•Pyrogenium 12X*
•Deactivation
(through M
e •Stimulation of
inflammation)
inflammation) and
and su tab
xin tion
neutralization
of the o
•Synergistic
Synergistic action
action with
Fucus
Fucus and
and thyroid
thyroid hormone
activating
activating the
sympatheticotonic
toxin
system**.
•Pyrogenium 12X*
•Thuja 6/8/12/30/200X**
Mesenchymopathy
•Inactive
Inactive toxins
toxins mobilized
(psychcosis).**
towards
towards the
the lymphatic
lymphatic circle
for drainage
•Pyrogenium 12X*
•Deactivation
(through M
e •Stimulation of
inflammation)
inflammation) and
and su tab
xin tion
neutralization
of the o
•Synergistic
Synergistic action
action with
Fucus
Fucus and
and thyroid
thyroid hormone
activating
activating the
sympatheticotonic
toxin
system**.
•Pyrogenium 12X*
•Thuja 6/8/12/30/200X**
Mesenchymopathy
•Inactive
Inactive toxins
toxins mobilized
(psychcosis).**
towards
towards the
the lymphatic
lymphatic circle
for drainage
DETOXIFICATION AND DRAINAGE THERAPY
Extra-
cellularmatrix
Lymphatic
circulation
Kidneysexcr Bowelexcre
etion tion
Liverexcreti
on
Myosotis 3X
GUNA-LYMPHO
D-L Malic Ac./Fumaricum Ac./Pyruvicum Ac.
Equisetum 3X Trychinoil/Natrium oxalac.
Hydrocotile 1X
•Reduction of local Taraxacum 1X
inflammation on lympho- Sarsaparilla 3X
epithelial tissues. Lymphatic vessel 6X
•Stimulation of Lymph
Capillary tisssue 6X
• Reduction of lymphatic flow with stabilization of
L-Thyroxin 6/12X
spasm due to vessel wall tone with
Vein porcine 6X
inflammation with consequent reduction of
restoration of the the exudate and the
lymphatic circulation. lymphoedema.
REACTIVATION OF THE
LYMPHATIC
CIRCULATION
Hydrastis 1X
ANTI-INFLAMMATORY HYPERTROPHY
AND HYPERPLASIA Juglans 3X
Calendula 1X ACTIVITY ON THE
OF THE LYMPHATIC Graphites 6/12/30/200X
Phytolacca 3X LYMPHO-EPITHELIAL
ORGANS
Apis 8X TISSUES
Magnesia phosph.
6/12/30/200X STRENGHTENING
IMMUNE DEFENCE
•Inhibition
Inhibition of
of the
the
•Stimulation of proliferative
proliferative tendencies
tendencies of
of
Humoral Immunity the
the lympho-epithelial
lympho-epithelial
and inhibitory tissues
tissues
modulation of the Magnesium
excessive cell phosphoricum
mediated 6/12/30/200X
compensatory 85
Juglans regia 3X
response © Dipartimento Scientifico Guna S.p.a.
Bryonia 6/8X
•Protection
Protection of
of epithelium*.
epithelium*. Nux vomica 6/8X
• Anti-putrefaction
and anti-
anti- Vit. B1 4X, Vit. B3 2X
dysbiosis
dysbiosis action
action **.
**. Vit. B5 2X
Colon, porc. 6/12/30X
Vitamin D* 2X Rectum porc. 6/12/30X
n ive
In imu
st
ac ner i-
te la
tio at
Skatolum** 6/10X
st tio
ge An
in n
• Stimulation of
al
intestinal function in
de
general.
• Regulation of • Stimulation of
Consitutional Laxative peristalsis.
constitutional proneness
rebalance action •Decrease of rectal
atony episodes.
Hepatic Aloe 2X
Rhamnus 2X
Rheum 2X
Carduus 2X* •Laxative action to

• Reduction of portal stasis*. treat episodes of
Collinsonia 2X* irritation of intestinal
•Choleretic and cholagogue
action**. Chelidonium 2X** mucosa.
Taraxacum off. 2X** 86

GUNA-LIVER
Taraxacum 2X*
• Rebalancing of the Carduus 2X*
constitutional weakness of
Chelidonium 2X**
the hepatic subject
Ceanothus 6X** • Stimulation of hepatic filter
Kalium sulfuricum 6/8/12X function *.
• Choleretic and cholagogue
Natrium sulfuricum 6/8/12X
activity (direct
hyperbilirubinemia and
CONSTITUTIONAL icterus)**.
• Triglyceride hydrolysis CORE
stimulation and support in
forms of hepatic steatosis*,
(hereditary)
hypercholesterolemia
reduction (Inositol METABOLIC FUNCTIONAL
ACTIVATION Leptandra 6X*
especially)*. CORE
CORE Chionanthus 6X*
• Hepatic damage caused by
alcohol**. Lycopodium 6X**
• Restoration of metabolic Hepar suis 6X***
function of the hepatocytes
Gal Bladder 8X***
and liver homeostasis***.
Pancreas suis 8X***
• Anti-inflammatory and anti-congestive
Spleen 8X***
Ac. Fumaricum 4X* activity on liver and gallbladder*.
Vit. B1/B2/B3/B6/B12 * Jejunum p. 8X***
• Stimulation of enzymatic function **.
Inositol 4X*
Cholinum 4X** • Stimulation of general function of the liver
Natrium oxalaceticum 4X*** and organs belonging to the digestive
Natrium pyruvicum 4X*** system*** 87
GUNA-KIDNEY Solidago 1X*
Equisetum 3X*
Ononis 2X*
Ortosiphon 2X*
•Renal cell metabolic support Sarsaparilla 2X*
Mouse ear hawkweed 1X*
Plantago 2X**
Pareira 2X**
Acidum nitricum 6/8/12X***
Ac. Succinicum 6X Kalium nitricum 6/8/12X***
ho rem
Cl eop die
ts
m e
Quihynidron 8X
as a s
ys
si thi
Methileneblue 8X
al
c
t
Ca •Activation of excretory
function of kidney and renal
c
renal ducts**.
Su a
s
is ra
de
or tio
the genital-urinary tract***.
so
•Stimulation of homologous
ga n
No
np s
organ function.
re
•Anti-degenerative action
p
on homologous organs.
secondary to infection
Kidney 6/8X
Colibacillinum 12X •Activation of specific
Ureter 6/8X immune response in
Proteus 12X
Urinary bladder 6/8X cystitis
88
DRAINAGE STRATEGY IN
CHRONIC DISEASES
GUNA-CELL
+
GUNA-MATRIX
+
GUNA-LYMPHO
DRAINAGE through a healthy PARALLEL ORGAN
Good hepatic Good intestinal Good renal

function: function: function:
GUNA-LIVER GUNA-BOWEL GUNA-KIDNEY89
GUNA CELL -lipoic-ac. 3X
Succinic. ac. 3X
• Carrier action*.
• Reprogramming of cell function**. Fumaric. ac. 3X
• 2nd
nd function messenger***. Methyglyoxal 10X
St Increase of energetic
Ac.-L-carnitine* 2X g im
tin n u metabolism.
DNA** 6X a o
ul cti re c lat
sp ell in
RNA** 6X ti m f un ira g
S ll tio
Collinsonia 2X*** ce n
cAMP 6X*** Mn-gluc. 3X
c
thi Tra Mn-phosph. 6X
a s
o p
i e elem ce Mg-phosph. 3X
e d en
om e ts P 4X
Anti-degenerative and H r em Ca-gluc. 3X
anti-aging action.
Vitamins Fe fumar. 3X
Colchicum 6/12/30X S 3X
Conium 6/12/30X Se 3X
Podophyllum 6/12/30X Cu sulph. 3X
Methyglyoxal 10X Vit. E Zn-gluc. 3X
Vit. C K-aspart. 3X
Vit. B1, B2, B3, B5,
B6, B9, B12 Catalytic action on
enzyme functions.
Coenzyme activity performing catalytic
action on cell functions. 90
40 drops poured
40 drops poured
into the bottle
into the bottle
10 pellets poured
40 drops poured
into the bottle
into the bottle
40 drops poured
into the bottle
40 drops poured
into the bottle
DRAINAGE & DETOXIFICATION
DIRECTIONS
•GUNA-MATRIX: 20 dropstwice a dayfor at least 2 months
•GUNA-LYMPHO: 20 dropstwice a dayfor at least 2 months
•GUNA-CELL: 20 dropstwice a dayfor at least 2 months
•GUNA-KIDNEY: 20 dropstwice a dayfor at least 2 months

•GUNA-LIVER: 5 pelletstwice a dayfor at least 2 months
•GUNA-BOWEL: 20 dropstwice a dayfor at least 2 months
ALL THE A.M. PRODUCTS CAN BE TAKEN TOGETHER

(forexampleputting 30-40 dropsofeach medicine in 1 litrebottleof
water. The patientdrinksthisbottleduring the wholeday)

93
MENTAL DRAINAGE
Normal DISEASE
FILTER SYSTEM
Harmful Physiologic Harmful Physiologic

stimulus stimulus stimulus stimulus
NOXAE NOXAE
TWO QUESTIONS
1.WHAT IS THE MENTAL

DRAINAGE?
2.HOW CAN I MANAGE THE
MENTAL DRAINAGE?
95
1.WHAT IS THE MENTAL
DRAINAGE?
TO RESTORE PHYSIOLOGICAL FILTER TO

KNOW, TO UNDERSTAND, TO INTERPRET
PERSONAL EXPERIENCE
EU-STRESS DI-STRESS
96
MENTAL DRAINAGE?
1. GUNA-MALE; 1. GUNA-MOOD;
2. GUNA-FEMALE; 2. GUNA-FLAM;
3. EUBIOFLOR.
1. GUNA LYMPHO;
2. GUNA BOWEL;
3. GUNA KIDNEY 97
GUNA-MOOD
•Melatonin synthesis and consequent
•Indirect
regularization of the NEUROENDOCRINE
regulation of
HOMEOSTASIS (neuro-endocrine
the
Reprogramming)
hypothalamic
activity
AVENA SATIVA
ALFA ALFA
CORPUS
PINEALIS GLANDULA
Antiastenic THYMI
TRIPTOFANO
and SALMONELLA
SEPIA
neurotonic TYPHI IDROSSITRIPTOFANO
ACIDUM PHOSPHORICUM
action IGNATIA
SINERGISMO
LACHESIS
SEROTONINA
SALIX
•Similarity to •Psychastenia (Ac.

typhus Phosphoricum) and
(depression, depression with Control of the mood
confusion, irritability (Sepia) by the
delirium) serotoninergic
activity

The NORTH STAR of every acute and chronic
inflammatory disease treatment
according to LDM

• Regulation of the
Wide rangeactivitydrug Aconitum*
Belladonna*
extracellular matrix Ferrum phosphoricum*
function through the
modulation of the
GUNA-FLAM Apis*
Bryonia*
hypophysary hormons Pyrogenium*
action and the pineal Phytolacca*
gland stimulation.
ne Natrium pyruvicum*
i
cr Acidum citricum*
in a
o
fla ct
Cu-gluconate*
An ma
n d
-e tion
m ion
Anti IL 1-alfa**
ti- tor
o
r ac
u TGF 1 beta***
Ne
IL 10***
y
Melatonin 4C
Hypophysis porcine 200X
An on
ti
Pineal Gland 6X t
ac ise ac
c
Conjunctive tissue 12X tio pt l gi • Modulation of the
n ic ti-a neurogenic, vasal exudative
An phases of the inflammatory
process*.
Hepar sulfuris • Hindrance to the
Pyrogenium inflammation start point**.
Aconitum*
Ferrum phosphoricum Beta-endorphin** • Potentiation of the
immunologic anti-
inflammatory activity
having Th2-Th3 polarity***.
• RES stimulation and hindrance
to the possible septic
progression of the • Modulation of the neurogenic phase of
inflammatory process. inflammation*.
• Sensitization of the beta-endorphin peripheral
100
© Dipartimento Scientifico Guna S.p.a. receptors**.
ANXIETY DISORDERS
•GUNA-MOOD: 3-5 pellets 2-3

times a dayfor 4-6
•GUNA-FEM: 20 dropstwice a months(forgeneral neuro-
dayfor 4-6 months vegetative regulation, Stress
conditions)
+
•GUNA – BOWEL: 10 drops3times a

dayfor2months (3+1 law)
•GUNA-MATRIX: 20 dropstwice a dayfor 4-

6 months
101
Targets for the tropism of GUNA complex
PSYCHE remedies
P PSYCHO
N NEURO
E ENDOCRINE
I IMMUNOLOGY
SOMA PSYCHE
I E N P

GUNA-MOOD
•Indirect
regulation of
the
Reprogramming)
hypothalamic
activity
AVENA SATIVA
ALFA ALFA
CORPUS
PINEALIS GLANDULA
Antiastenic THYMI
TRIPTOFANO
and SALMONELLA
SEPIA
ACIDUM PHOSPHORICUM
action IGNATIA
SINERGISMO
LACHESIS
SEROTONINA
SALIX

activity

–Regulation of
thymic hormone Regulation of
NEURO-ENDOCRINE insulin response
synthesis
REPROGRAMMING (irregular under
(immune
system stress
strengthening) conditions)
PINEAL GLAND
THYMUS GLAND MELATONIN

PANCREAS SUIS
HYPOTHALAMUS
HYPOPHISIS OOPHORINUM
cAMP CORPUS
LUTEUM SUIS
GLANDULA
SUPRARENALIS SUIS GUNA LILIUM
THYROIDINUM
-FEM
•Regulation of
cortisol and
catecholamine •Regulation of
synthesis (greater thyroid hormone Stimulation of
stress resistance). (irregular under gonad
•Stimulation of sex stress function in
hormone synthesis conditions) woman
Bryonia 6/8X
•Protection
Protection of
of epithelia*.
and anti-
anti-
dysbiosis
dysbiosis action
action **.
**. Nux vomica 6/8X
e
Vitamin B1, B3 e B5
ti v
Vitamin D* 2X
on a
In imu
ti er
st
• Stimulation of
te la
ac e n
st tio
eg
in n
general.
al
id
nt
• Stimulation of
A
peristalsis.
Hepatic Aloe 2X
Rhamnus 2X
Rheum 2X
Taraxacum off. 2X
GUNA-MATRIX •Ac. D-L malicum*
•Natrium oxal.*
•Pyrogenium*
•Fucus* •Natrium pyruv.*
•Tyrosine** •NADID*
•Phenilalanine** •Trychinoil*
•Histidine** •Vit. C*
•Ac. L(+) lacticum**
•Deactivation
(through M
e •Stimulation of the energetic
inflammation)
inflammation) and
and
ins tion su tab mitochondrial activity.*
neutralization
of x pp oli
To liza
the
impregnation toxins*. or c •Matrix acidification
tra
impregnation toxins*. t
u (promoting the connective
•Synergic
Synergic action
action with
with Fucus
Fucus ne reactivity).**
of
of the
the thyroid
thyroid hormons
hormons
activating
activating the
the Action against
sympatheticotonic
nervous •IL 6*
toxin Matrix
system**.
system**. •DHEA*
impregnation drainage
•Pyrogenium*
•Hyaluronidase* •Conjunctive Tissue*
Lymphatic •Tyrosine**
•Thuja**
•Natrium sulfuricum**
drainage •Phenilalanine**
•Prolactine*** •Histidine**
•DHEA*** •Prolactine***
•Increase of the Fundamental
Substance cynetics (protein
proneness to a matrix histaminic activity, >
impregnation and to the •Lymphatic vessel temperature) and of the matrix
development of a Dysmetabolic turnover.*
Mesenchymopathy (Sycosis).**
•Inactive
Inactive toxins
toxins canalization
canalization •Sympatheticotonic
•Matrix solubilization.*** towards
towards the
the lymphatic
lymphatic circle
for
for the
the drainage
drainage •Vagotonic slowdown.***
GUNA METHOD
PHARMACOLOGY
107
Guide Lines of Therapeutic Strategy
according with PRM
“how to build a therapy according with PRM
principles”
108
WHY AND IN WHICH CASES

GUNA - LYMPHO
109
WHY
GUNA - LYMPHO
110
GUNA-LYMPHO Myosotis
Equisetum
Trychinoil/Natrium oxalac.
Hydrocotile
•Reduction of the Taraxacum
localphlogosis on the Sarsaparilla
lymphoepithelialtissues. Lymphatic vessel
•Lymphagogue action
Capillary tisssue
•Reduction of the and stabilization of the
L-Thyroxin
lymphaticspasm on vasal walls tone with
Vena
inflammatorybasis with consequent reduction of
followingrestoration of the the extudate and the
lymphaticcirculation. lymphoedema.
REACTIVATION OF THE
LYMPHATIC
CIRCULATION
Hydrastis
AND HYPERPLASY Juglans
ACTIVITY ON THE
Calendula OF THE LYMPHATIC Graphites
LYMPHOEPITELIAL
Phytolacca ORGANS
TISSUES
Apis
Magnesia phosph.
STRENGHTENING OF
THE IMMUNE
DEFENCE •Hindrance to the
•Humoral immunity proliferative proneness of
stimulation and the lymphoepitelial tissues
inhibitory modulation
of the excessive cell Magnesium
mediated phosphoricum
compensatory Juglans regia
response
Equisetum
Hydrocotile
Capillary tisssue
L-Thyroxin
Vena
REACTIVATION OF THE
LYMPHATIC
CIRCULATION
Hydrastis
ACTIVITY ON THE
LYMPHOEPITELIAL
Phytolacca ORGANS
TISSUES
Apis
Magnesia phosph.
STRENGHTENING OF
THE IMMUNE
response
Equisetum
Hydrocotile
Capillary tisssue
L-Thyroxin
Vena
REACTIVATION OF THE
LYMPHATIC
CIRCULATION
Hydrastis
ACTIVITY ON THE
LYMPHOEPITELIAL
Phytolacca ORGANS
TISSUES
Apis
Magnesia phosph.
STRENGHTENING OF
THE IMMUNE
response
IN WHICH CASES
GUNA - LYMPHO
114
GUNA - LYMPHO WHICH CASES
Lymphaticstasis (lymphedemas);
Extracellularmatrixdetoxification;
Inflammatorydiseases of the
lymphaticorgans (lymphadenitis,
lymphangitis);
Hyperplasia or hypertrophy of the

lymphaticorgans.
115
GUNA - LYMPHO COMMON COMBINATIONS
Guna-Lympho + Guna-Matrix + Guna-Liver:
detoxification and drainagetherapy in patients with
goodliverfunction.
Guna-Lympho + Guna-Matrix + Guna-Bowel:

goodbowelfunction.
Guna-Lympho + Guna-Matrix + Guna-Kidney:

goodkidneyfunction.
Guna-Lympho + GunaFem: venousinsufficiency with

lymphaticstasis.
Guna-Lympho + Guna-SinusNosesparay:
lymphadenopathies. 116
ABSCESS
GUNA-FLAM (10 drops

CITOMIX (10 pellets2times a
every 15 minutes in acute
dayfor 2-3 days; continue
phase; continue with 10
with3pellets3times a dayfor
drops3times a dayfor 15
15 days)
days)
+
GUNA-LYMPHO (10 drops3times a

dayfor 30 days)
117
ADENOID HYPERTROPY
GUNA-SINUS NOSE spray

CITOMIX (10 pellets2times a
2puff3times a dayfor 15
dayfor 2-3 days; continue
days)
with3pellets3times a
+
dayfor30-60 days)
GUNA-LYMPHO (10 drops3times a

dayfor 30-60days) + EUBIOFLOR (10
drops4times a dayfor 30-60 days).
118
CELLULITIS
GUNA-MATRIX + GUNA-
GUNA FEM (10drops3times
LYMPHO (10
a dayfor 30-60 days) +
dropseach3times a dayfor
EUBIOFLOR (10
30-60 days)
drops4times a dayfor 30-60
+
days)
GUNA-KIDNEY (15 drops3times a dayfor

60-90 days)
119
CERIVICOGENIC HEADACHE
GUNA-FLAM (10 drops

GUNA-MOOD (10
several times a day;
continue with 10 drops 3
days)
times a day for 30-60 days)
GUNA-MATRIX (10 drops3times a dayfor 30-

60 days) + GUNA-LYMPHO (10 drops3times
a dayfor 30-60 days)
120
CHOLELITHIASIS (GALL STONES)
GUNA-LIVER (3-5
CITOMIX (3pellettsmorning
pelletts3times a dayfor 30-
and eveningfor 30-60 days)
60 days)
GUNA-LYMPHO (10 drops3times a dayfor

30-60 days)
121
CHOLELITHIASIS (GALL STONES)
GUNA-LIVER (3-5
CITOMIX (3pellettsmorning
pelletts3times a dayfor 30-
and eveningfor 30-60 days)
60 days)

30-60 days)
122
DERMATOMYCOSIS
(RINGWORM OF THE NAILS)
GUNA-MYCOX (20
CITOMIX (3pellettsmorning drops3times a dayfor 30-60
and eveningfor 30-60 days) days) continue with 10
drops3times a dayforother
30 days).
Itisalsoadvisabletoapply3/5dr
ops in the interested part.

30-60 days)
123
DYSLIPIDEMIA
(MILD TO MODERATE)
GUNA-LIVER
GUNA FEM/MALE (10 (5pelletts3times a dayfor 30-
drops3times a dayfor 30-60 60 days)
days)
GUNA MATRIX + GUNA-LYMPHO (10

drops3times a dayfor 30-60 days)
124
INFECTION, CHRONIC, RECURRENT
CITOMIX (5pelletts3times a
GUNA FEM/MALE (10 dayfor 30-60 days)
days)

30-60 days)
125

GUNA - MATRIX
126
WHY
GUNA - MATRIX
127
•Natrium oxal.*
•Pyrogenium*
•Deactivation
Deactivation M
(throughinflammation)
(throughinflammation) and
and
neutralization of the x pp oli
To liza
impregnationtoxins*. or c •Matrix acidification
tra
impregnationtoxins*. t
•Synergicaction
Synergicaction with
with Fucus
of
of the
the
thyroidhormonsactivating
thyroidhormonsactivating Action against
the
the •IL 6*
toxin Matrix
sympatheticotonicnervoussy
sympatheticotonicnervoussy •DHEA*
stem**. impregnation drainage
stem**. •Pyrogenium*
•Thuja**
•Inactive
Inactive toxins
toxins canalization
towards the
the lymphatic
lymphatic circle
for
for the
the drainage
•Natrium oxal.*
•Pyrogenium*
•Deactivation
Deactivation M
and
To liza
tra
•Synergicaction
Synergicaction with
with Fucus
of
of the
the
the
the •IL 6*
toxin Matrix
•Thuja**
•Inactive
Inactive toxins
toxins canalization
towards the
the lymphatic
lymphatic circle
for
for the
the drainage
•Natrium oxal.*
•Pyrogenium*
•Deactivation
Deactivation M
and
To liza
tra
•Synergicaction
Synergicaction with
with Fucus
of
of the
the
the
the •IL 6*
toxin Matrix
•Thuja**
•Inactive
Inactive toxins
toxins canalization
towards the
the lymphatic
lymphatic circle
for
for the
the drainage
IN WHICH CASES
GUNA - MATRIX
131
GUNA - MATRIX WHICH CASES
Detoxification and drainage of
extracellularmatrix.
132
GUNA - MATRIX COMMON COMBINATIONS
Guna-Matrix + Guna-Lympho + Guna-Liver: detoxification and

drainagetherapy in patients with goodliverfunction.
Guna-Matrix + Guna-Lympho + Guna-Bowel: detoxification and

drainagetherapy in patients with goodbowelfunction.
Guna-Matrix + Guna-Lympho + Guna-Kidney: detoxification and

drainagetherapy in patients with goodkidneyfunction.
Guna-Matrix + Guna-SinusNose spray: preventive treatment of

allergies, in particular in patientspreviouslytreated with
corticosteroids.
Guna-Matrix + Guna-Liver + Guna-Cell: pharmaceuticaldamage

(iatrogenicdiseases).
Guna-Matrix + Guna-Micox: coadiuvant treatment of michosis

133
AUTISM ADJUVANT TREATMENT
GUNA MOOD (10

GUNA FEM/MALE (10 drops3times a
drops3times a dayfor 30-60 dayforextendedperiodoftime)
days)
GUNA-MATRIX+GUNA-LYMPHO+GUNA-
CELL+GUNA- KIDNEY (10 dropseach3times
a dayfor 30-60 days)
134
CROHN’S DISEASE
(ILEITIS AND COLITIS)
EUBIOFLOR (10 drops3times
GUNA MOOD (10 a dayfor 30-60 days) or/and
drops3times a dayfor 30-60 GUNA BOWEL (10
days) + GUNA FLAM drops3times a dayfor 30-60
days).
GUNA-MATRIX (10 dropseach3times a

dayfor 30-60 days)
135
LIVER DISEASE
GUNA LIVER (5pellets3times

GUNA FEM/MALE (10 a dayfor 30-60 days)
days)
GUNA-MATRIX (10 dropseach3times a

dayfor 30-60 days)
136
CHRONIC SINUSITIS
GUNA SINUS NOSE SPRAY

CITOMIX (5pelletsmorning (2puff in eachnostril 4-5
and eveningfor 30-60 days) times a
dayoverextendedperiodsofti
me) + GUNA FLAM (10
days)
GUNA-MATRIX + GUNA CELL (10

dropseach3times a dayfor 30-60 days)
137
CHRONIC SINUSITIS
GUNA SINUS NOSE SPRAY

CITOMIX (5pelletsmorning (2puff in eachnostril 4-5
and eveningfor 30-60 days) times a
dayoverextendedperiodsofti
me) + GUNA FLAM (10
days)
GUNA-MATRIX + GUNA CELL (10

dropseach3times a dayfor 30-60 days)
138

GUNA - BOWEL
139
WHY
GUNA - BOWEL
140
Bryonia 6/8X
•Protection
Protection of
of epithelia*.
and anti-
anti-
dysbiosis
dysbiosis action
action **.
**. Nux vomica 6/8X
e
Vitamin B1, B3 e B5
ti v
Vitamin D* 2X
on a
In imu
ti er
st
• Stimulation of
te la
ac e n
st tio
eg
in n
general.
al
id
nt
• Stimulation of
A
peristalsis.
Hepatic Aloe 2X
Rhamnus 2X
Rheum 2X
Taraxacum off. 2X
Bryonia 6/8X
•Protection
Protection of
of epithelia*.
and anti-
anti-
dysbiosis
dysbiosis action
action **.
**. Nux vomica 6/8X
e
Vitamin B1, B3 e B5
ti v
Vitamin D* 2X
on a
In imu
ti er
st
• Stimulation of
te la
ac e n
st tio
eg
in n
general.
al
id
nt
• Stimulation of
A
peristalsis.
Hepatic Aloe 2X
Rhamnus 2X
Rheum 2X
Taraxacum off. 2X
Bryonia 6/8X
•Protection
Protection of
of epithelia*.
and anti-
anti-
dysbiosis
dysbiosis action
action **.
**. Nux vomica 6/8X
e
Vitamin B1, B3 e B5
ti v
Vitamin D* 2X
on a
In imu
ti er
st
• Stimulation of
te la
ac e n
st tio
eg
in n
general.
al
id
nt
• Stimulation of
A
peristalsis.
Hepatic Aloe 2X
Rhamnus 2X
Rheum 2X
Taraxacum off. 2X
IN WHICH CASES
GUNA - BOWEL
144
GUNA - BOWEL IN WICH CASES
Acute and
chronicconstipationaswellasspastic
and atonicconstipa-tion, regulatorof
the intestinalfunction,
detoxificationof the digestive
system, coadjuvant in the
degenerative pathologiesof the
digestive canal.
145
GUNA - BOWEL COMMON COMBINATIONS
Guna-Bowel + Eubioflor + Proflora + Profos:

intestinaldysbiosis.
Guna-Bowel + Guna-Liver: digestive disorders;

persistentconstipation.
Guna-Bowel + Guna-Digest + Guna Mood + GunaFlam:

irritable colon syndrome.
Guna-Bowel + Guna-Flam:
IBD (InflammatoryBowelDiseases).
146
AGORAPHOBIA
GUNA MOOD (10 drops 3

GUNA FEM/MALE (10 drops times a day for extended
3 times a day for 30-60 period of time)
days)
GUNA BOWEL (10 drops each 3 times a day

for 30-60 days)
147
BRONCHIAL ASTHMA
GUNA MOOD (10 drops 3 GUNA FLAM + GUNA FLU (10

times a day for extended drops 3 times a day for
period of time) extended period of time)
GUNA BOWEL (10 drops each 3 times a day

for 30-60 days)
148
ABDOMINAL COLICS
GUNA MOOD (10 drops 3 GUNA FLAM (10 drops 3

times a day for extended times a day for extended
period of time) period of time)
GUNA LIVER – liver colic (5 pellets 3 times a

day fro 60 days) or GUNA-KIDNEY – kidney
colic or GUNA BOWEL – Bowel colic (10
drops each 3 times a day for 30-60 days)
149
CONSTIPATION
GUNA MOOD (10 drops 3 GUNA BOWEL (10 drops

times a day for extended every 15 minutes for 2 hours;
period of time) continue with 10 drops 3
times a day for 60 days)
GUNA LIVER (5 pellets 3 times a day for 60

days)
150
CROHN’S DISEASE
EUBIOFLOR (10 drops 3

GUNA MOOD (10 drops 3 times a day for 60 days) and
times a day for extended GUNA BOWEL (10 drops 3
period of time) times a day for 60 days) and
GUNA FLAM (10 drops 3
GUNA MATRIX (10 drops 3 times a day for

60 days)
151
IRRITABLE BOWEL SYNDROME
GUNA MALE/FEM (10 drops EUBIOFLOR (10 drops 3

3 times a day for 60 days) times a day for 60 days)
GUNA BOWEL (10 drops 3 times a day for

60 days)
152
CYSTIS
CITOMIX (10 pellets twice a

day for 2-3 days; continue
GUNA KIDNEY (10 drops 3
with 3 pellets 3 times a day
for 60 days)
EUBIOFLOR (10 drops 3 times a day for 60

days) + GUNA BOWEL (10 drops 3 times a
day for 60 days)
153
REACTIVE DEPRESSION
GUNA MALE/FEM (10 drops GUNA MOOD (10 drops 3


day for 60 days)
154
DYSURIA
EUBIOFLOR (10 drops 3 GUNA KIDNEY (10 drops 3

times a day for 60 days)) times a day for 60 days)

day for 60 days)
155
IRRITABLE BOWEL SYNDROME
GUNA MALE/FEM (10 drops EUBIOFLOR (10 drops 3


60 days)
156
NEUROTIC DEPRESSION

3 times a day for 60 days) times a day for extended
period of time)

60 days)
157
PERTUSSIS (WHOOPING COUGH)
CITOMIX (10 pellets twice a GUNA COUGH (one 10 ml

day for 3 days; continue 3 dose 3 to 6 times a day for 3
pellets 3 times a day for 60 times a fday for 30 days.
days) Pediatric dosage; one 5 ml
dose 3 to 6 times a day for 30
days)

60 days)
158
RECURRENT RESPIRATORY INFECTIONS
CITOMIX (10 pellets twice a GUNA FLU (1 dose a week

day for 3 days; continue 3 for 8 weeks. Repeat the cycle
pellets 3 times a day for 60 after 45 days). – GUNA FLAM
days) (10 drops 3 times a day for
extended period of time)
GUNA BOWEL + GUNA-LYMPHO (10 drops 3

159
RECURRENT URINARY TRACT INFECTIONS
CITOMIX (10 pellets twice a GUNA KIDNEY (10 drops 3

day for 3 days; continue 3 times a day for 60 days)
pellets 3 times a day for 60
days)
GUNA BOWEL + EUBIOFLOR (10 drops 3

160
STRESS

3 times a day for 60 days) times a day for extended
period of time)
GUNA BOWEL + GUNA-LYMPHO (10 drops 3

161

GUNA - KIDNEY
162
WHY
GUNA - KIDNEY
163
GUNA-KIDNEY Solidago*
Rubia*
Equisetum*
•Support to the metabolism of the Ononis*
renal cell. Ortosiphon*
Sarsaparilla*
Mouse ear hawkweed*
Plantago**
Pareira**
Ac. Succinicum Acidum nitricum***
ho rem
Cl eop die
Kalium nitricum***
ts
m e
Quihynidron
as a s
ys
si thi
Methileneblue
al
c
t
Ca •Activation of the excretoric
funcion of kidney and renal
c
•Stimulation of the the renal ducts**.
Su pa
s
homologous organs
pr
de
is ra
e
function. the genital-urinary
so
or tio
No
apparatus***.
ga ns
•Antidegenerative
n
action on the
homologous organs.
forms on infective
basis
Kidney
Colibacillinum •Activation of the
Ureter specific immune
Proteus
Urinary bladder response in case of
cystitis
IN WHICH CASES
GUNA - KIDNEY
165
GUNA - KIDNEY IN WHICH CASES
Kidneyfailure;
Cystopyelitis;
Nephrolithiasis;
Hydronephrosis;
Nephrosclerosis;
Hyperthension.
166
GUNA - KIDNEY COMMON COMBINATIONS
Guna-Kidney + Citomix:
recurrenturinarytractinfections.
Guna-Kidney + Guna-Flam:
urinarytractinflammation.
167
“SWOLLEN FACE”
•GUNA-FEM: 20 dropstwice a
dayfor 4-6 months •GUNA-MOOD: 3-5 pellets 2-3
•GUNA-MALE: 20 dropstwice times a dayfor 4-6
a dayfor 4-6 months months(forgeneral neuro-
+ vegetative regulation, Stress
conditions)
•GUNA – BOWEL: 10 drops 3

times a dayfor 2 months (3+1
law)
•GUNA-MATRIX: 20
dropstwice a dayfor 4-6
months
168
ALBUMINURIA
CITOMIX (10 pellets twice a GUNA-KIDNEY (10 drops 3

day for 3 days; continue 3 times a day for 60 days) +
pellets 3 times a day for 60 GUNA FLAM (10 drops 3
days) times a day for 60 days)
GUNA LIVER (5 pellets 3 times a day for 60

days)
169
CHOLANGITIS
CITOMIX (3 pellets morning GUNA-LIVER (5 pellets 3

and evening for 60 days) times a day for 60 days)
GUNA-KIDNEY (10 drops 3 times a day for

60 days)
170
CHOLECYSTITIS
CITOMIX (3 pellets morning GUNA-LIVER (5 pellets 3

and evening for 60 days) times a day for 60 days)
GUNA-KIDNEY + GUNA-CELL (10 drops 3

171
ABDOMINAL COLICS
GUNA-FLAM (10 drops each

CITOMIX (3 pellets morning every 15 minutes in the acute
and evening for 60 days) phase; continue with 10
drops 3 times a day for 30
days)
GUNA-KIDNEY – Kidney colic (10 drops 3

times a day for 60 days)/ GUNA LIVER – liver
colic (5 pellets 3 times a day for 60 days)
172
DIARRHEA
EUBIOFLOR (10 drops 3

times a day for 60 days) GUNA-BOWEL (10 drops 3
GUNA-KIDNEY (10 drops 3 times a day for

60 days)
173
GASTROENTERITIS

day for 3 days; continue with EUBIOFLOR (10 drops 3
3 pellets 3 times a day for 15 times a day for 60 days)
days)
GUNA-KIDNEY (10 drops 3

174
HEPATITIS

day for 3 days; continue with GUNA-LIVER (5 pellets 3
3 pellets 3 times a day for 15 times a day for 60 days)
days)
GUNA-KIDNEY (10 drops 3 times a

day for 60 days)
175
NEPHROLITHIASIS
GUNA-FLAM (10 drops 3

times a day for 60 days) GUNA-KIDNEY (10 drops 3
GUNA-LIVER (5 pellets 3
176

GUNA - LIVER
177
WHY
GUNA - LIVER
178
GUNA-LIVER
Taraxacum*
• Rebalance of the Carduus*
constitutional weakness of
Chelidonium**
the hepatic subject
Ceanothus** • Stimulation of the
Kalium sulfuricum hepatic filter function *.
• Choleretic and
Natrium sulfuricum
colagogue activity (direct
hyperbilirubinaemia and
CONSTITUTIONAL icterus)**.
• Triglycerides hydrolysis CORE
stimulation, (hereditary)
hypercholesterolemia
reduction and support in the
forms of hepatic steatosis*.
METABOLIC FUNCTIONAL
• Hepatic damage caused by ACTIVATION Leptandra*
alcohol**. CORE
CORE Chionanthus*
• Restoring of the metabolic
Lycopodium**
funcion of hepatocyte and
liver homeostasis***. Hepar suis***
Gal Bladder***
Pancreas suis***
• Anti-inflammatory and anticongestive
Ac. Fumaricum* Spleen***
activity on liver and gallbladder*.
Vit. B1/B2/B3/B6/B12* Jejunum p.***
Inositol* • Stimulation of the enzymatic function **.
Cholinum** • Stimulation of the general function of the
Natrium pyruvicum*** liver and the organs belonging to the
Natrium oxalaceticum*** digestive system***
IN WHICH CASES
GUNA - LIVER
180
GUNA - LIVER IN WHICH CASES
Hepatic insufficiency,
Hepatic hypercholesterolemia;
Hepatobiliary detox.;
Cholelithiasis with hyperbiliru.;
Hepatic steatosis;
Alcoholism;
Digestive disorders.
181
GUNA - KIDNEY COMMON COMBINATIONS
Guna-Liver+Guna Matrix+ Guna Cell:

pharmaceutical damage (iatrogenic diseases);
Guna Liver+Guna Bowel: digestive disorders;

persistent constipation;
182
ACNE VULGARIS
GUNA MALE/FEM (10 drops

GUNA-FLAM (10 drops 3
3 times a day for 60 days)
GUNA-LIVER (5 pellets 3
183
MENTAL DRAINAGE
Normal DISEASE
AntiIL1
FILTER SYSTEM

NOXAE NOXAE
TWO QUESTIONS
1.WHO IS THE MENTAL

DRAINAGE?
MENTAL DRAINAGE?
185
1.WHO IS THE MENTAL
DRAINAGE?
TO RESTORE PHYSIOLOGICAL FILTER TO

KNOW, TO UNDERSTAND, TO INTERPRET
PERSONAL EXPERIENCE
EU-STRESS DI-STRESS
186
MENTAL DRAINAGE?
DRUGS NEUROPEPTIDES, GROWTH FACTORS,
HORMONES, INTERLEUKINES
•Brain Derived Neurotrophic Factor BDNF;

1. GUNA-MOOD; •Insulin-like Growth Factor (IGF1)-(NT3,
NT4, BDNF);
2. GUNA-MALE; •Nerve Growth Factor (NGF)-PNEI reg.
3. GUNA-FEMALE. •Anti IL 1 4CH/IL 10 4CH (IL-1 sleep, appetite,

sex drive, fatigue);
•IL4 4CH (IL-6 appetite);
•IL 11 4CH (IL-2 memory, cognition);
•IL-1 norepinephrine and serotonine;
•IL-2 serotonine;
•TSH D6 (ACTH), Mlelatonin 4CH (Prolactin),
•Serotonin D6, Triptophan D6
187
ANTI AGE STRESS Thalamus, porc. 7C
Stomach, porc. 7C
Cortex cerebralis, porc. 4/7C
Melatonin 4/15C
Adrenalinum 9/15C
• Action against free Plexus solaris 7C
radicals*. • Neuroendocrine
Neuroendocrine axis
axis
• Action against brain reprogramming.

reprogramming.
degeneration**. P.N.E.I.
REBALANCE (1)
G.C.S.F. 4C
n-Acetyl cysteine* 4C
ANTI- P.N.E.I. Interferon gamma 5C
Glutathione* 4C DEGENERATIVE REBALANCE (2)
Sporobolomyces gr. 8X
CORE
Kali carb.** 9C
Penicillium not. 8X
SYMPTOMATIC
CORE
• Antianxiety action *. • Immune-endocrine

Immune-endocrine
• Anti-stress action**. axis
axis reprogramming.
reprogramming
Argentum nitr.* 9C
• Mood stabilization***. Citrus decumana* 3X
Black horehound * 3X
Nux vomica** 5/7/9/15C
Lithium carb.*** 8X
ARGENTUM NITRICUM
MIND
Thinks his understanding will and must fail.

Fearful and
nervous; impulse to jump out of window.
Faintish and
tremulous. Melancholic; apprehensive of
serious disease.
Time passes slowly (Cann ind). Memory
weak. Errors of perception. Impulsive; wants
to do things in a hurry (Lilium). Peculiar
mental impulses. Fears and anxieties and
hidden irrational motives for actions.
189
GUNA- Zincum met. 3X*
Vanadium met. 6X*
•Stimulation
Stimulation of
of glucose
glucose
Chromium sulph. 3X*
metabolism*
metabolism*
AWARENESS Folic acid 3X**
Trimethylglicine 3X**
•Modulation
Modulation of
of
Ferrum met. 3X***
Calcarea carb. 3X*** homocysteinemia**
homocysteinemia**
•Trophic
Trophic action
action on
on nervous
nervous Molybdenum met 3X*** •Stimulation
Stimulation of
of general
general
structures Cobalamin 3X***
structures metabolic
metabolic cell
cell activity
activity ***
***
•Antioxidant
Antioxidant action
action
METABOLIC SUPPORT TRH 3X

BDNF (Brain Derived
OF CNS FUNCTIONS Neurotrophic Factor) 4C
Frontal lobe porcine 6X
Temporal lobe porcine 6X
NT3 (Neurotrophin 3) 4C Zincum met. 3X
ANTIDEGENERATIVE IMPROVEMENT
NT4 (Neurotrophin 4) 4C Bufo rana 12X
Melatonin 4C ACTION ON CNS OF COGNITIVE Silicea 12X
FUNCTIONS
Coenzyme Q 3X Cicuta virosa 12X
Cuprum met. 12X
IMPROVEMENT OF
SOCIAL RELATIONS
AND INTERRELATIONS
•Improvement
Improvement of of memory,
memory,
concentration, cognitive
concentration, cognitive
activity
activity and
and expressive
expressive
•Improvement
Improvement of of language
language
social
social relations
relations Oxytocin
Oxytocin 6X
6X
disposition
disposition Melatonin
Melatonin 4C
4C
Aurum
Aurum met.
met. 12X
12X
Lachesis
Lachesis mutus
mutus 12X
12X
Neurotrophin Evolution
Neurotrophins have only been isolated from chordates

Hallbook (1999) Curr Opin Neurobiol9: 616-21
GUNA-MOOD
•Indirect
regulation of
the
Reprogramming)
hypothalamic
activity
AVENA SATIVA
ALFA ALFA
CORPUS
PINEALIS GLANDULA
Antiastenic THYMI
TRIPTOFANO
and SALMONELLA
SEPIA
ACIDUM PHOSPHORICUM
action IGNATIA
SINERGISMO
LACHESIS
SEROTONINA
SALIX

activity

MENTAL DRAINAGE
Normal DISEASE
AntiIL1
FILTER SYSTEM

NOXAE NOXAE

Moldavia Lu Pard in I

Hochgeladen von

Dokumentinformationen

Originaltitel

Copyright

Verfügbare Formate

Dieses Dokument teilen

Dokument teilen oder einbetten

Freigabeoptionen

Stufen Sie dieses Dokument als nützlich ein?

Sind diese Inhalte unangemessen?

Copyright:

Verfügbare Formate

Moldavia Lu Pard in I

Hochgeladen von

Copyright:

Verfügbare Formate

GUNA INTERNATIONAL COURSE

PHYSIOLOGICAL REGULATING MEDICINE

The mechanism of action in the drainage therapy of GunaLympho,

The information presentedhereisnottobeconsidered a

Why choose it?

SINGLE COMPONENT MULTICOMPONENT

Molecular Biology Homeopathic Science

•CITOMIX: 10 granules a week •GUNA-KIDNEY: 20 dropstwice a

function. the genital-urinary

© Dipartimento Scientifico Guna S.p.a.

•COLIBACILLINUM 6/12/30X •COLON PORCINE 6/12/30X

•ANANASSA SATIVA 3X •MEDULLA OSSIS SUIS 4C

•HYDROCOTYLE ASIAT. 3X •THYMUS GLAND 4C

•CITOMIX: 10 granules a week •GUNA-FLU: 1 dose a week for 6-

•ANANASSA SATIVA 3X •MEDULLA OSSIS SUIS 4C

•HYDROCOTYLE ASIAT. 3X •THYMUS GLAND 4C

© Dipartimento Scientifico Guna S.p.a.

CUPRUM 3C Anas barbariae 200K

© Dipartimento Scientifico Guna S.p.a.

SIGNALING MOLECULES are

© Dipartimento Scientifico Guna S.p.a.

pcg(picogram)= 10 -12 = 0.000000000001

fg(fentogram)= 10 -15 = 0.000000000000001

© Dipartimento Scientifico Guna S.p.a.

Soluble TNF receptor

© Dipartimento Scientifico Guna S.p.a.

© Dipartimento Scientifico Guna S.p.a.

WITH SKA: WITHOUT SKA:

10-15 MINIMAL EFFECTIVE PHYSIOLOGICAL DOSE

© Dipartimento Scientifico Guna S.p.a.

P CENTRAL NERVOUS SYSTEM

Ader, R., Psychoneuroimmunology, IV edition, vol. 1 e 2, Academic Press, Amsterdam 2007.

•Glycemia 60 -110 mg/dl

I •Iron 60 -160 mcg/dl male; 20 -140 mcg/dl female

DISEASE © Dipartimento Scientifico Guna S.p.a.

P CENTRAL NERVOUS SYSTEM

Ader, R., Psychoneuroimmunology, IV edition, vol. 1 e 2, Academic Press, Amsterdam 2007.

© Dipartimento Scientifico Guna S.p.a.

© Dipartimento Scientifico Guna S.p.a.

© Dipartimento Scientifico Guna S.p.a.

© Dipartimento Scientifico Guna S.p.a.

© Dipartimento Scientifico Guna S.p.a.

TAKE CARE OF YOUR

•COLIBACILLINUM 6/12/30X •COLON PORCINE 6/12/30X

Vitamin D* 2X Rectum porc. 6/12/30X

Carduus 2X* •Laxative action to

Taraxacum off. 2X** 56

“…vitamin D deficiency is a critical factor in the pathology of

• TO CURE THE HUMAN BEING

• TO ACT ON THE CAUSES AND

• TO CONSIDER THE HUMAN

© Dipartimento Scientifico Guna S.p.a.

DRAINAGE AND DETOXIFICATION

© Dipartimento Scientifico Guna S.p.a.

© Dipartimento Scientifico Guna S.p.a.

With the Physiological Regulation Medicine (Guna

© Dipartimento Scientifico Guna S.p.a.

A stressorsaccumulation in thisplacerepresents the

The membrane receptorplays a veryimportantrole.

Only the physiologicconcentrationisabletoactivate or

PATHOLOGIC PROCESS HEALING

“HYPER” OR “HYPO” STRESSOR STORAGE (MATRIX

ALTERATION OF THE PNEI