Beruflich Dokumente
Kultur Dokumente
IMMUNOLOGICAL
TOLERANCE
Jan Żeromski
2007/2008
BASIC FACTS ABOUT TOLERANCE
• Tolerance – a state of
unresponsiveness specific for a given
antigen
• It is specific (negative) immune
response
• It is induced by prior exposure to that
antigen
BASIC FACTS ABOUT TOLERANCE-2
Central Peripheral
• The site for T cells is • The site – everywhere
the thymus in the body
• The site for B cells • Cells – both T and B
is the bone marrow • Mechanisms – anergy,
• The mechanism – cell death, immune
clonal deletion deviation
IMPORTANT OPPOSED TERMS