What is Epilepsy? The word epilepsy derives from the Greek verb epilambanein, meaning to be seized, to be overwhelmed by surprise. Epilepsy is the most common serious brain disorder in the world (International League Against Epilepsy) with 50 million people around the planet having some type of Epilepsy. (WHO) Epilepsy is a chronic non-communicable disorder of the brain that affects people of all ages. (WHO) Epilepsy is a disorder of the brain that causes seizures. (CDC) Any of various disorders marked by abnormal electrical discharges in the brain and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. (Merriam-Webster). There are many different types of epilepsy, including West Syndrome, Doose Syndrome, Benign Rolandic Epilepsy, Rasmussen’s Syndrome, Lennox-Gastaut Syndrome, Landau- Kleffner Syndrome, Sturge-Weber Syndrome, Juvenile Myoclinic Epilepsy, Frontal Lobe Epilepsy, Temporal Lobe Epilepsy, Parietal Lobe Epilepsy, and Occipital Lobe Epilepsy. The History of Epilepsy Reports of epilepsy date back thousands of years, one of the earliest being 1780 B.C. in the Hammurabi code, which stated that a person with epilepsy could not marry or even testify in court. Many religions for hundreds of years believed epileptic people to be demonic and possessed, even prone to violence and contagious. Hippocrates, in 400 B.C. wrote about the previous superstitions being false because “the gods do not make men’s bodies unclean . . . Its cause lies in the brain . . . Therefore, epilepsy can and must be treated not by magic, but by diet and drugs.” In the early 19th century, French physicians such as Maisonneuve, Calmeil, and Esquirol researched and published work in epileptology. They stressed the importance of hospitalization of epileptic individuals. Proof of epilepsy deriving from the brain is credited to psychiatrist Hitzig and physiologist Fritsch in the 1880s. In the late 19th and early 20th centuries, many treatments started to be tested, including starvation, electric shock therapy, and more. The History of Epilepsy (Cont.) Jean Pascal Gastaut worked to discover the significance of EEG. He also opened the first school for epileptic children in France in 1958. Until 1980, it was still illegal for people with epilepsy to get married in several states. The law that prohibited marriage in epileptic individuals in the UK was repealed in 1970. Some parts of the world still prohibit marriage to epileptic individuals. In 1956, 18 states provided for sterilization, on eugenic grounds, of people with epilepsy. Until the 1970s, it was still legal in the United States to deny persons with seizures entry to public places such as restaurants, theaters, etc. It was not until 1990 that the ADA started to prevent such discrimination. Famous people in history with epilepsy include Alexander the Great, Peter the Great, Julius Caesar, Richelieu, Charles V, Joan of Arc, Händel, Berlioz, Flaubert, Petrarch, Byron, van Gogh, Dostoevky, and Gershwin. What Causes Epilepsy? One or more genes may cause the epilepsy or epilepsy may be caused by the way some genes work in the brain. The relationship between genes and seizures can be very complex and genetic testing is not available yet for many forms of epilepsy. About 3 out of 10 children with Autism Spectrum Disorder may also have seizures. The exact cause and relationship is still not clear. Infections of the brain, strokes, tumors, and sever head injuries can also cause epileptic seizures. Problems with neonatal care or birth can cause epileptic-like seizures. This includes brain malformations, lack of oxygen, maternal drug use, etc. Febrile seizures are not a form of epilepsy sometimes happen in children ages 6 months to 5 years. They can, however, pose a greater risk of epilepsy, especially with longer lasting seizures. Types of Seizures Generalized seizures affect both sides of the brain. Absence seizures, sometimes called petit mal seizures, can cause rapid blinking or a few second of staring into space. Tonic-clonic seizures, also called grand mal seizures, can make a person cry out, lose consciousness, fall to the ground, or have muscle jerks or spasms. People often feel tired after this type of seizure. Focal seizures are located in just one area of the brain, also called partial seizures. Simple focal seizures affect a small part of the brain, can cause twitching or a change in sensation, such as a strange taste or smell. Complex focal seizures can make a person with epilepsy confused or dazed, making them unable to respond to questions for up to a few minutes. Secondary generalized seizures begin in one part of the brain and then spread to both sides of the brain. Medications for Epilepsy Brivatacetam Pregabalin Carbamezapine In general, people with Primidone Felbamate epilepsy only respond well to Rufinamide treatment about 80% of the Clobazam Topiramate time. Clonazepam Ezogabine Diazepam Nearly 80% of people with Phenytoin Gabapentin epilepsy live in low income Perampanel countries and about ¾ of Lacosamide Oxcarbazepine people with epilepsy never Lamotrigine Ethosuximide get any treatment. Levetricatem Lorazepam Life with Epilepsy. . . Children with epilepsy can have trouble learning for various reasons, including often having other learning disabilities. Children with epilepsy also have a higher risk of developing depression and/or attention deficit hyperactivity disorder compared with their peers. Children are especially vulnerable to the emotional problems caused by ignorance or the lack of knowledge among others about epilepsy. This often results in stigmatization, bullying, or teasing of a child who has epilepsy. Depression is common among people with epilepsy. It is estimated that one of every three persons with epilepsy will have depression in the course of his or her lifetime, often with accompanying symptoms of anxiety disorder. Most states will not issue driver’s licenses to people with epilepsy. Although discrimination against people with epilepsy is illegal, certain medications can have side effects that interfere with memory and concentration, making working or being in a classroom difficult. That’s All Folks!