Beruflich Dokumente
Kultur Dokumente
Lecture Outline
I. Objectives
II. Historical perspective
III. What is a virus
– A. Characteristics
– B. Comparison to bacteria
IV. Nucleocapsid morphology
– A. Helical
– B. Polyhedral
– C. Complex
V. How viruses multiply
– A. Basic strategy
– B. Bacterial viruses
– C. Animal viruses
– D. Culturing viruses in the lab
VI. How to classify viruses?
– A. Formal taxonomies
– B. Baltimore Classification
– C. Which means what?
VII. Viruses and the diseases they cause
– A. Class I: dsDNA
– B. Class II: ssDNA
– C. Class III: dsRNA
– D. Class IV: ss(+)RNA
– E. Class V: ss(-)RNA
– F. Class VI: ss(+)RNA with dsDNA
intermediate
VIII.Summary of effects of viral infection
on cells
IX. Oncogenic viruses
X. Viroids
XI. Prions
I. Objectives
What is a virus
Bacteria Virus
Intracellular parasite (no) yes
Plasma membrane yes no
Binary fission yes no
Filterable no yes
Possess DNA & RNA yes no
ATP production yes no
Ribosomes yes no
Antibiotic sensitive yes no
2. Size comparison
B. Polyhedral
C. Complex
V. How viruses multiply (13.10)
A. Basic strategy
– Attachment
– Penetration
– Synthesis of viral proteins and nucleic acids
– Maturation
– Release
B. Bacterial viruses: Fig 13.12
Lytic vs lysogenic cycle
C. Animal Viruses
D. Culturing viruses in the lab
1. bacteriophage
2. animal viruses
VI. How to classify viruses?
A. Formal taxonomies
B. Baltimore classification
Genus
Species
– 2. Plant
3. Human host
– a. Herpesviridae
– b. Adenoviridae
– c. Poxviridae
– d. Papovaviridae
» Papillomavirus
» Polyomavirus
» Vacuolating agent
– e. Hepadnaviridae
B. Class II: ssDNA viruses
1. Bacteria
2. Plant
3. Human
– A. Parvoviridae
C. Class III: dsRNA viruses
1. Reoviridae
D. Class IV: ss (+) RNA viruses
1. Picornaviridae
2. Togaviridae
3. Flaviviridae
4. Coronaviridae
5. Calciviridae
E. Class V: ss (-) RNA viruses
1. Rhabdoviridae
2. Filoviridae
3. Paramyxoviridae
4. Orthomyxoviridae
5. Bunyaviridae
Retrovirus Life Cycle: Fig 13.19
F. Class VI: ss (+) viruses
(dsDNA intermediate)
1. Retroviridae
– Oncoviruses
– Lentivirus
G. Review of Replication
Strategies
VIII. Summary of effects of viral
infection on cells
IX. Oncogenic Viruses
X. Viroids
XI. Prions
A. Fig 13.21
B. PrPC vs PrPSc
– Structural differences
– Detergent solubility differences
– Differences in susceptibility to protein
degrading enzymes
Prion diseases of humans and
animals