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` Always check the dose of the drug for the
specific species
` Do not do calculations in your head
` Check the packaging for the specific
formulation
` Double check your calculated dose
 |

Vhere do I get doses from?
` Mormulary
` Veterinary Drug Handbook, DC Plumb
` Veterinary Mormulary, M Papich
` Make your own
` Use a text book
` Veterinary Pharmacology and Therapeutics, HR Adams
` Experience
` Please don¶t
` IVS
` Package insert
 V 

 


The most important step
Read the label for conc.
Vritten as % m/v
mg/ml
 Ô 

 



` Animal weight (kg)
` Dosage (mg/kg) (Also referred to as the dose rate)
` How many mg are in the bottle (mg/ml) / tablet (mg/tablet)

How many mg does the animal need

= weight x dosage

Answer = mg needed
mg in bottle/tablet
 Veight of animal x dose rate
Amount of =
drug to give
Amount of drug/unit

It is very important to use the same units

  
 

` A dog weighs 25 kg
` The dog needs 2 mg/kg BM of Rimadyl®
` How many tablets should the dog get, if each
tablet contains 100mg
 Ô 

 



` Animal weight (kg) a 
` Dosage (mg/kg) a
` How mg are in the tablet (mg/tablet) 


How many mg does the animal need

= weight x dosage

mg needed
Answer =
mg in bottle/tablet
 w 



` 3eeds: 25 kg x 2 mg/kg = 50 mg
` 100mg per tablet

mg needed
` 3umber of tablet =
mg in tablet

50 mg
` Thus = 100 mg Tablet

=
1
Tablet
2
  
 
` Dog needs 2mg/kg of a certain prednisolone.
` He weighs 20 kg
` Solution come in 10 mg/ml
 Ô 

 



` Animal weight (kg) a
` Dosage (mg/kg) a
` How mg are in the bottle (mg/ml) 

How many mg does the animal need

= weight x dosage

mg needed
Answer =
mg in bottle/tablet
  
 
` 3eeds: 20kg x 2mg = 40 mg
` Solution contains 10 mg/ml
` 3umber of ml needed
mg needed
=
mg in bottle
40 mg
=
10 mg

= 4 ml
  
 
` A foal weighs 60 kg
` It needs a dose of 30mg/kg of Ceftiofur
` All we know is that it is a 10% m/v solution
` Vhat volume does the foal get
 Ô 

 



` Animal weight (kg) £
` Dosage (mg/kg) 
` How mg are in the bottle (mg/ml) 

How many mg does the animal need

= weight x dosage

mg needed
Answer =
mg in bottle/tablet
  

` 10 % m/v (sometimes referred to as w/v)
Solute

10 m Solvent
=
100 v

10 g % m/v x 10 = mg/ml
=
100 ml 10 % m/v x 10 = 100 mg/ml

10 000 mg
=
100 ml

= 100 mg/ml
 

` Mg needed: 60kg X 30mg/kg = 1 800 mg
` Mg in bottle: 10 % solution = 100 mg/ml

1800mg
` Volume needed =
100mg/ml

` 3eed 18 ml
 
  

- A dog of 20 kg, needs a dose of doxycycline
at 10mg/kg BID for 7 days. Each tablet
contains 100mg of drug. How tablets should
the dog receive per day. How many tablets
should you dispense?

- A cow weighs 500kg. It needs 10mg/kg of

tetracyclines. The bottle contains a 5% m/v
solution. Vhat dose does this cow need?
  
 


` Vhat information do you need?
` Patient¶s weight
` Mluid dosage (dose rate) (normally ml/kg)
` Type of fluid
` Drip set¶s rate (60, 20, 10 drops/ml)
  
 


Total Mluid Requirement: BV x Recommendation

Duration of treatment: Period of administration (sec)
Drip set rate: 10/15/60 drops/ml

ml/sec = Total Mluid Requirement (ml)

Duration of administration (sec)

Drop/Sec = ml/Sec X Drip set rate

  
 


Calculate the drip rate for a £ dog that needs
 fluid. A 60 drops/ml drip set will be
used and the fluid will be administered over £


ml/sec = total fluid volume
Duration
= 6 kg x 50 ml/kg
6h X 3600sec
= 300 ml
21 600 sec
= 0.014 ml/sec
  
 


Calculate the drip rate for a 6 kg dog that needs
50ml/kg fluid. A £
 drip set will be
used and the fluid will be administered over 6
hours

Drops/sec = ml/sec X drip set rate

= 0.014 ml/sec X 60 drops/ml
= 0.83 drop/sec
~ 1drop/1sec
  
!
 


Total Mluid Requirement: BV x Recommendation

Duration of treatment: Period of administration (h)

ml/hr = Total Mluid Requirement (ml)

Duration of administration (h)
 
!
 


Calculate the drip rate for a 6 kg dog that needs
50ml/kg fluid. Mluid will be administered over 6
hours

ml/sec = total fluid volume

no of sec
= 6 kg x 50 ml/kg
6h
= 300 ml
6h
= 50 ml/h
 Ú 
 

Make a 1 liter 2.5% solution of dextrose from a
50% dextrose solution
C1V1 = C2V2
Concentrate Dilution
C1= Concentration you have C2=Concentration you want
V1=Volume you need to draw up V2= Volume of drip bag

50% X V1 = 2.5% X 1L
V1 = 2.5L
50
= 0.05L
  



!
 

- A horse of 450 kg need to placed on a CRI of
lignocaine at a dose of 0.05 mg/kg/min.
- How many grams of lignocaine needs to be
dissolved into a 1L saline to allow you to
administer the saline drip fluid at a rate of 1
drop every 3 seconds,
- ou have to make use of a 10 drop infusion
drip set, as an infusion pump is not available
  



!
 

` Dose needed 450 x 0.05 mg/kg/minute
= 22.5 mg/minute
` 10 drop set = 10 drops/ml
` Thus 1 drop/3 sec = 20 drops/minute
= 2 ml/minute
` Thus need 22.5mg in every 2ml
= 11.5 mg/ml
` Thus need 11.5 g for every litre of drip fluid