Patofisiología II

OSTEOPOROSIS-
OSTEOARTROSIS(OSTEOARTRITIS)

Walter Espino Saavedra

Médico AnatomoPatologo
Universidad Católica Santo Toribio de Mogrovejo- USAT
2017
 LOCALIZADO

OSTEOPORISIS

GENERALIZADO
Fractura de vertebra con compresión
 Estado
Edad hormonal
Trabeculas delgadas ampliamente separadas
 Trabeculas
delgadas
ampliamente
separadas.

En osteoporosis senil la
cortical se adelgaza por
resorcion subperiostica y
endostica y los sistemas de
havers se ensanchan
Trabeculas
finas de
hueso
cortical
ESTUDIOS QUE PEDIRÍAS :
Densitometría
Dosar Ca+
Hormona PTH

Steroid-induced
osteoporosis.
Osteoporosis is defined as
a systemic skeletal disease
with microarchitectural
deterioration of bone and
disrupted and thin
trabeculae, which leads to
poor bone strength. A
secondary cause of
osteoporosis is shown with
sparse trabeculae and
unfilled tunneling and
resorption space.
Glucocorticoids lead to
poor bone formation
OSTEOARTROSIS
(OSTEOARTRITIS)
A. Normal joint covered by normal articular cartilage

B. Fragmentation & thinning of articular cartilage

C. Patchy loss of cartilage & exposing the subcondrial

bone (eburnation)

D. Extensive loss of cartilage, cystic degeneration of

underlying bone & osteophytes formation

Radiograph
showing the hand
with erosive
osteoarthrosis -
involvement of the
proximal
interphalangeal
joints
Picture showing the gross
appearence of the femoral head
removed from a patient with
osteoarthrosis. The polished area
is the exposed bone (eburnation).
The roughened surface is the
normal area covered by the
articular cartilage.
 Se forman quistes en el hueso

Osteoarthritis.
Severe osteoarthritis with 1, Eburnated articular surface exposing subchondral bone. 2, Subchondral cyst. 3, Residual articular
cartilage.
Osteoarthritis.
Histologic demonstration of the characteristic fibrillation of the articular
 Cambio de color +
rosa por fibrosis

Histology showing the articular cartilage in osteoarthrosis.

A. Fissuring (flanking) B. Irregular surface of the articular cartilage
 No hay cartílago , solo tejido
inflamatorio , regenerativo con
fibrosis
Nodulos de heberden