mTOR

mTOR

Mammalian
target of
rapamicyn
Rapamicina
 Inmunosupresor
 Forma complejo FKPB 12-sirolimus
 Compite con unión mTOR
mTOR
 Metbolismo
 Crecimiento
 Proliferacion
 Sobrevida
mTOR
 Serina/treonina cinasa
 2549 aa
 Terminal amino de repeticiones HEAT (Huntingtin
Elongation factor 3ª subunit of protein phosphatase 2A and
TOR1)
 Dominio central FAT (Focal AdhesionTarget)
 Dominio FRB (FKBP12-rapamycin binding)
 Dominio actividad kinasa
 Dominio FACT (carboxy-terminal homology domain)
mTOR complex 1
(mTORc1)

mTOR complex 2
(mTORc2)
mTORC1
 mTOR (subunidad catalica)
 RAPTOR (regulatory-associated protein of mTOR)
 mLST8 (mammalian lethal whit sec13 protein)
 PRAS40 (proline-rich AKT sobstrate 40kDa)
 DEPTOR (DEP-domain-containing mTOR-interacting
protein)
mTORC2
 mTOR
 RICTOR (Rapamycin-Insensitive Companion mTOR)
 mSIN1 (mammalian stress-activated protein kinase
interacting protein)
 PROTOR (protein observed whit Rictor)
 mLST8
 DEPTOR
mTORC1
 Promueve traduccion de ARN mensajero
 Inhibe autofagia
 Aminoácidos
 Insulina
 Factores de crecimiento similares a insulina (IGF)
 AMP
 Hipoxia
 Estímulos mecanicos
 Daño ADN
 PI3K
 Akt
 Ras-ERK
 Inhibición de complejo supresor de tumores TSC 1 /2