Seorang Pasien dengan Dengue

Syok Sindrom
Etiologi
Virus Flavivirus golongan Flaviviridae yang
dibawah oleh nyamuk Aedes aegypti dan Aedes
albopictus.
DF/DHF Grade Tanda dan Gejala Laboratorium
DF Fever with two of the following: • Leukopenia (leikosit ≤ 5000
Panas dengan 2 dari gejala: sel/mm3)
Headache. •Sakit kepala • Trombositopenia ( <150.000
Retro-orbital pain. •Nyeri retro - sel/mm3)
orbital • Peningkatan hematokrit (5% –
•Myalgia/ Nyeri otot 10% ).
Arthtralgia/bone pain. •arthralgia
atau nyeri tulang
• Rash (bintik merah pada kulit)
• Manifestasi perdarahan
• Tidak ada buktikebocoran plasma

DHF I • Panas dan terdapat manefestasi • Trombositopenia <100 000

perdarahan (positive tourniquet sel/mm3
tes) dan terdapat bukti • Peningkatan hematokrit ≥ 20%
kebocoran plasma
DHF II Seperti grade I ditambah • Trombositopenia <100
perdarahan spontan 000 sel/mm3
• Peningkatan hematokrit ≥
20%

DHF# III As in Grade I or II plus circulatory • Trombositopenia <100 000

failure (weak pulse, narrow pulse sel/mm3
pressure (=20 mmHg), • Peningkatan hematokrit ≥
hypotension, restlessness). 20%
Seperti grade I atau II ditambah
kegagalan sirkulasi (nadi lemah,
tekanan sistol dan diastol yang
berdekatan (≤ 20 mmHg)
hipotensi, kurang istirahat
DHF# IV As in Grade III plus profound shock • Trombositopenia <100 000
with undetectable BP and pulse sel/mm3
Seperti Grade III ditambah • Peningkatan hematokrit ≥
ditemukannya tanda shok dengan 20%
tekanan darah dan nadi yang tak
teraba
Management of shock: DHF Grade 3
• DSS is hypovolemic shock caused by plasma leakage and characterized by
increased systemic vascular resistance, manifested by narrowed pulse
pressure (systolic pressure is maintained with increased diastolic pressure,
e.g. 100/90 mmHg). When hypotension is present, one should suspect
that severe bleeding, and often concealed gastrointestinal bleeding, may
have occurred in addition to the plasma leakage.
• DSS adalah hipovolemik syok yang disebabkan kebocoran plasma dan
karakteristik dengan peningkatan taekanan vaskular sistemik, manifestasi
berupa tekanan darah sistol dan diastol yang berdekatan.
• It should be noted that the fluid resuscitation of DSS is different from
other types of shock such as septic shock. Most cases of DSS will respond
to 10 ml/kg in children or 300–500 ml in adults over one hour or by bolus,
if necessary. Further, fluid administration should follow the graph as in
Figure 9. However, before reducing the rate of IV replacement, the clinical
condition, vital signs, urine output and haematocrit levels should be
checked to ensure clinical improvement.
• Dalam penerapannya resusitas cairan pada DSS berbeda dengan type syok
lainnya seperti syok septik. Kebanyakan kasus DSS akan memberi respon
perbaikan dengan pemberian 10 ml/Kg pada anak atau 300-500 ml pada
dewasa setelah 1 jam atau dengan pemberian secara bolus,jika
diperlukan.
• Management of shock: DHF Grade 4
• The initial fluid resuscitation in Grade 4 DHF is more vigorous in order to
quickly restore the blood pressure and laboratory investigations should be
done as soon as possible for ABCS as well as organ involvement. Even mild
hypotension should be treated aggressively. Ten ml/kg of bolus fluid
should be given as fast as possible, ideally within 10 to 15 minutes. When
the blood pressure is restored, further intravenous fluid may be given as in
Grade 3. If shock is not reversible after the first 10 ml/kg, a repeat bolus of
10 ml/kg and laboratory results should be pursued and corrected as soon
as possible. Urgent blood transfusion should be considered as the next
step (after reviewing the preresuscitationHCT) and followed up by closer
monitoring, e.g. Continuous bladder catheterization, central venous
catheterization or arterial lines.
• Penerapan Resusitasi cairan pada DHF grade 4 lebih regresif untuk
mengembalikan tekanan dan
• It should be noted that restoring the blood pressure is critical for survival
and if this cannot be achieved quickly then the prognosis is extremely
grave. Inotropes may be used to support the blood pressure, if volume
replacement has been considered to be adequate such as in high central
venous pressure (CVP), or cardiomegaly, or in documented poor cardiac
contractility.