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BENEFITS: HARMS:
• Heat • Suntan
• Light • Sunburn
• Photosynthesis • Premature aging
• Outdoor environment • Freckles
for physical activity • Liver spots
• Production of • Wrinkles
vitamin D • Loss of elasticity
• Happy and positive • Cataracts
• Suppression of
feelings
immune system
• Actinic keratosis
• Skin cancer
The Sun’s radiation spectrum
– Time of day.
• Physical
– Opaque formulations containing:
• titanium dioxide
• talc, kaolin
• zinc oxide
• ferric chloride
• icthyol, red petrolatum
– Mechanism: scatters or reflects UV radiation
due to large particle size
SUNSCREEN CLASSIFICATIONS
• Chemical
– Formulations containing one or more:
• PABA, PABA esters
• benzophenones
• cinnamates
• salicylates
• digalloyl trioleate
• anthranilates
– Mechanism: absorbs UV radiation
Suntans & Sunburns
• Octyl methoxycinnamate
• Octocrylene
• Ethylhexyl methoxycinnamate
• Octyl dimethyl PABA
• Tinosorb
Reflecting compounds
• Titanium dioxide
• Zinc oxide
1. Molecules capture
energy from the
sun’s UV rays
2. The energy give the
molecule thermal
motion (vibrations
and rotations)
3. The energy is re-
emitted as
harmless long
wave IR
Source: Adapted from http://www.3dchem.com/molecules.asp?ID=135#and http://members.aol.com/WSRNet/tut/absorbu.htm
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• Appearance Matters
• Traditional inorganic
sunscreens have appear
white on our skin
• Many people don’t like
how this looks, so they
don’t use sunscreen with
inorganic ingredients
• Of the people who do use
them, most apply too little
to get full protection
Source: http://www.4girls.gov/body/sunscreen.jpg
Why Do They Appear White?
Source: http://www.smalltimes.com/images/st_advancednanotech_inside_.jpg
SUNCREEN AGENTS
PABA (Para-aminobenzoic acid)
• Very effective in the UVB range (200-320 nm).
• Most effective in conc of 5% in 70% ethanol.
• Maximum benefit when applied 60 min prior to
exposure (to ensure penetration and binding to stratum
corneum).
• Does NOT prevent drug/chemical-induced
photosensitivity rxn.
• Contact dermatitis can develop.
• May produce transient drying/stinging from alcohol
content (may be alleviated by adding 10-20% glycerol).
• May stain clothing.
SUNCREEN AGENTS
• Less staining
SUNCREEN AGENTS