Beruflich Dokumente
Kultur Dokumente
Chapter 24
Antimicrobial Drugs
•Alexander Fleming’s Serendipitous Discovery of Penicillin
Ushered in the Era of Antibiotics
•The toxic dose of a drug is the concentration causing harm to the host
•Together, the toxic and therapeutic doses are used to formulate the
chemotherapeutic index
Drugs have a range of pathogens on which they will work
(antimicrobial spectrum)
•meningitis
•cholera
•typhoid and typhus fevers
•Rocky Mountain spotted fever
5. Bacteria may evolve the ability to prevent drug entry into the
cytoplasm or to pump the drug out of the cytoplasm