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MOUSE

GAMETOGENESIS

CHROMOSOME NUMBER:

MOUSE OVARY : MOUSE TESTIS :

photo here photo here

EGG SIZE SPERM SIZE


TYPE
GAMETOGENESIS
GAMETOGENESIS
FERTILIZATION

TYPE OF FERTILIZATION:

ADDITIONAL
ACTUAL PHOTO OF
EXPLANATION ON
A FERTILIZED EGG
FERTILIZATION
FERTILIZATION
What nine events have to occur to mouse sperm in the course of a successful fertilization? Capacitation; secretion of hyaluronidase to

penetrate cumulus; binding to zona; acrosome reaction; digestion of zona; sperm–egg membrane recognition; plasma membrane fusion;

nuclear decondensation; pronuclear fusion.

BE ABLE TO
EXPLAIN THIS WELL
FERTILIZATION

WHAT IS ZP3 AND WHAT IS ITS SIGNIFICANCE?


CLEAVAGE AND BLASTULA

DEFINE : 1. BLASTOCYST 2. TROPHECTODERM


CLEAVAGE AND BLASTULA
CLEAVAGE AND BLASTULA
What is the difference between a Xenopus blastula and a mouse blastocyst?

The Xenopus blastula is a ball of cells surrounding a fluid-filled cavity, all of which will form part of the later

embryo. The mouse blastocyst also has a fluid-filled cavity but the outer layer is a differentiated trophectoderm,

required for implantation, while the inner cell mass forms both the embryo and parts of the placenta other than the

trophectoderm.

PHOTO OF
PHOTO OF MOUSE
XENOPUS
BLASTOCYST HERE
BLASTULA HERE
CLEAVAGE AND BLASTULA
POLARIZATION
GASTRULATION

BE ABLE TO
EXPLAIN THIS WELL
GASTRULATION

Explain the difference between parietal endoderm, visceral endoderm, and definitive endoderm in the mouse embryo.

The parietal and visceral endoderms originate from the primitive endoderm of the blastocyst. The parietal endoderm lines the

trophectoderm, while the visceral endoderm lines the egg cylinder. The definitive endoderm consists of cells that have migrated through

the primitive streak and is destined to form the epithelial lining of the gut and respiratory system.

SHOW PHOTO OF
THE EGG CYLINDER
SHOWING THE
PARIETAL AND
VISCERAL
ENDODERM
GASTRULATION

PRIMITIVE STREAK
GASTRULATION

PRIMITIVE STREAK
GASTRULATION
ORGANOGENESIS
ORGANOGENESIS
ANTERO-POSTERIOR PATTERNING

How does anteroposterior pattern become

initiated in mouse development?

In a symmetry breaking process the radially

symmetrical egg cylinder undergoes

morphogenetic movements such that the Hex

domain ends up on one side and the T

domain on the other. This is the

anteroposterior axis. In the course of this

movement the distal visceral endoderm

becomes the anterior visceral endoderm and

secretes various anteriorizing factors, which

act on the underlying epiblast.


ANTERO-POSTERIOR PATTERNING

WHAT ARE HOX GENES AND THEIR SIGNIFICANCE?


MOUSE VERSUS HUMAN EMBRYO

Name four differences between early development of the human and the mouse.

(i) The human has proliferating trophoblast all round the blastocyst, in mouse only the polar trophectoderm proliferates.

(ii) In the human, the amniotic cavity arises within the inner cell mass, while in mouse the amnion grows across the proamniotic cavity from the proxim

(iii) The human has a flat blastodisc while the mouse has a cup-shaped egg cylinder. (iv) Extraembryonic mesoderm in the human arises well before the
MOUSE VERSUS HUMAN EMBRYO