Beruflich Dokumente
Kultur Dokumente
CHILDREN
Written by:
Abiyya Farah Putri 1102013003
Advisor:
dr. Pulung M. Silalahi, Sp.A
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EPIDEMIOLOGY
PERSON
• 39,38% berusia 0-5 tahun,
• 31,10 % berusia 6-10 tahun,
• 17,68% berusia 11-15 tahun,
GENETIC • 8,04 % berusia 16-20 tahun,
• 3,63 % berusia > 20 tahun.
AGE
PLACE
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SOURCE : Data Unit Kerja Koordinasi Hematologi Onkologi Anak Indonesia 2014)
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INHERITED AUTOSOMAL RECESSIVE HEMATOLOGIC DISORDERS 8
CLASSIFICATION
Berdasarkan gangguan pada rantai globin yang terbentuk:
Thalassemia-α Thalassemia-β
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CLINICAL SYMPTOMS
Pale and lethargic appearance
Decreased Appetite
Failure to Thrive
Yellowish skin
FACIES COOLEY
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DIAGNOSIS
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LABORATORY FINDINGS
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• Most persons with thalassemia trait, their complete blood
count shows a mild microcytic anemia.
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Hair on end Coarsed Trabeculae
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TREATMENT
Blood
Iron Chelation
Transfusion
Vitamin C,
Bone Marrow
Vitamin E & Folic
Acid Supplement
Transplant
Cord Blood
Splenectomy
Donors
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BLOOD TRANSFUSION
Confirmed diagnosis of thalassaemia
For deciding
whom to •Laboratory criteria:
transfuse, the
following should • Haemoglobin level (Hb <7 g/dl on 2 occasions,
be included in the 2 weeks apart (excluding all other contributory
investigations: causes such as infections)
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SPLENECTOMY
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BONE MARROW TRANSPLANT
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DIFFERENTIAL DIAGNOSIS
RDW Serum Iron TIBC Serum FEP
Ferritin
Iron Deficiency Inc Dec Inc Dec Inc
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PREVENTION
• Early detections
• If you have thalassemia, or if you carry a
thalassemia gene, consider talking with a
genetic counsellor for guidance before
you get marriage
• Your children maybe prevented from
thalassemia by choosing a thalassemia
free partner
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PROGNOSIS
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