Beruflich Dokumente
Kultur Dokumente
PANKAJ BS15B023
# CONTENTS HAVE BEEN TAKEN FROM BOOK ANATOMY & PHYSIOLOGY, KENNETH SALADIN
ANATOMY OF THE
RESPIRATORY SYSTEM
MECHANICS OF
Overview
VENTILATION
NEURAL CONTROL OF
VENTILATION
RESPIRATORY DISORDERS
The Respiratory System
The heart has an internal pacemaker and goes on beating even if all
nerves to it are severed.
Breathing, by contrast, depends on repetitive stimuli from the brain. There
are two reasons for this:
(1) Skeletal muscles do not contract without nervous stimulation.
(2) Breathing involves the coordinated action of multiple muscles and
thus requires a central coordinating mechanism to ensure that they
all work together
Respiratory control centers in
Brainstem
The respiratory centers are divided into four major groups, two groups in the medulla and
two in the pons.
• Present in medulla:
1. inspiratory center(or Dorsal respiratory group) - stimulate the muscles of
inspiration
2. expiratory center(or Ventral respiratory group) - It generally causes expiration but can
cause either expiration or inspiration depending upon which neuron in the group is
stimulated
• Present in Pons:
1. pneumotaxic center - It controls both rate and pattern of breathing. Limit inspiration
2. apneustic center - It discharges stimulatory impulse to the inspiratory center and
discharges inhibitory impulse to expiratory center
Afferent connections to the brainstem
The brainstem respiratory centers receive input from the limbic system,
hypothalamus, chemoreceptors, and lungs themselves
Input from the limbic system and hypothalamus allows pain and emotions
to affect respiration
Chemoreceptors in the brainstem and arteries monitor blood pH, CO2, and
O2 levels. They transmit signals to the respiratory centers that adjust
pulmonary ventilation to keep these variables within homeostatic limits.
The vagus nerves transmit sensory signals from the respiratory system to the
inspiratory center. Irritants in the airway, such as smoke, dust, noxious
fumes, or mucus, stimulate vagal afferent fibers.
Ondine’s curse
In German legend, there was a water nymph named Ondine who took a
mortal lover. When he was unfaithful to her, the king of the nymphs put a
curse on him that took away his automatic physiological functions.
Consequently, he had to remember to take each breath, and he could not
go to sleep or he would die of suffocation—which, as exhaustion overtook
him, was indeed his fate. Some people suffer a disorder called Ondine’s
curse, in which the automatic respiratory functions are disabled—usually as a
result of brainstem damage from poliomyelitis or as an accident of spinal cord
surgery. Victims of Ondine’s curse must remember to take each breath and
cannot go to sleep without the aid of a mechanical ventilator.
Respiratory disorders
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