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Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
7.1: Introduction
• Human skeleton initially cartilages and fibrous membranes
• Hyaline cartilage is the most abundant cartilage
• By age 25 the skeleton is completely hardened
• 206 bones make up the adult skeleton (20% of body
mass)
• 80 bones of the axial skeleton
• 126 bones of the appendicular skeleton
2
Bone Classification
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Long Bones
• Short Bones
• Sesamoid Bones
• Flat Bones
• Irregular Bones (c)
• Wormian Bones
(sutural)
(d)
3
(a) (e)
Parts of a Long Bone
• Epiphysis Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Epiphyseal plates
• Distal Articular cartilage
• Spongy bone
Compact bone
Medullary cavity
• Endosteum
• Medullary cavity
• Trabeculae
• Bone marrow
• Red marrow and yellow marrow
Distal
epiphysis
4
Femur
Microscopic Structure
5
Compact Bone
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Osteon Osteon
• Central canal
vessels and nerves
• Osteocytes
Perforating
canal
Compact Nerve
• Lamellae
bone
Blood
vessels
• Lacunae Nerve
Bone matrix
• Canaliculi Canaliculus
Osteocyte
Lacuna
(space)
6
Spongy Bone
• Spongy bone is aka cancellous bone
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Spongy
bone
Compact
bone
(a)
Remnant of Spongy bone Compact bone
epiphyseal plate
(b)
Spongy Compact
7
(c)
bone bone
a: © Ed Reschke; b,c: Courtesy of John W. Hole, Jr.
7.3: Bone Development
and Growth
• Parts of the skeletal system begin to develop
during the first few weeks of prenatal development
8
Intramembranous Bones
• Intramembranous Bones
• These bones originate within sheetlike layers of
connective tissues
• They are the broad, flat bones
• Skull bones (except mandible)
• Are known as intramembranous bones
9
Endochondral Bones
• Endochondral Bones
• Bones begin as hyaline cartilage
• Form models for future bones
• These are most bones of the skeleton
• Are known as endochondral bones
10
Endochondral Ossification
• Hyaline cartilage model • Epiphyseal plate
• Primary ossification center • Osteoblasts vs. osteoclasts
• Secondary ossification centers
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Articular
Remnants of cartilage
Secondary epiphyseal
ossification plates
Cartilaginous Developing Compact bone center
model periosteum developing Spongy
bone
Epiphyseal
plates
Blood
Medullary Medullary Medullary
vessel
cavity cavity cavity
Compact
bone
Remnant of
Epiphyseal epiphyseal
Calcified Primary plate plate
cartilage ossification Secondary Spongy
center ossification bone
center Articular
cartilage
(a) (b) (c) (d) (e) (f) 11
Growth at the Epiphyseal Plate
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
epiphysis 1 Zone of
resting
• Resting cells
cartilage
2 Zone of
to epiphysis 3 Zone of
hypertrophic
Ossified
bone of
cells diaphysis
• Undergoing mitosis
• zone of proliferating
cartilage
(a) (b)
b: © The McGraw-Hill Companies, Inc./Al Telser, photographer
12
Growth at the Epiphyseal Plate
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
2 Zone of
• Cells enlarging and proliferating
cartilage
cartilage
• Fourth layer of cells 4 Zone of
calcified
cartilage
• Thin Ossified
bone of
• Calcified extracellular
matrix
• zone of calcified
cartilage
(a) (b)
b: © The McGraw-Hill Companies, Inc./Al Telser, photographer
13
Homeostasis of Bone Tissue
• Bone Resorption – action of osteoclasts and parathyroid
hormone aka parathormone aka PTH
• Bone Deposition – action of osteoblasts and calcitonin
• Occurs by direction of the thyroid and parathyroid glands
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Developing
medullary
cavity
Osteoclast
14
© Biophoto Associates/Photo Researchers, Inc.
Factors Affecting Bone
Development, Growth and Repair
• Deficiency of Vitamin A – retards bone development
• Deficiency of Vitamin C – results in fragile bones
• Deficiency of Vitamin D – rickets, osteomalacia
• Insufficient Growth Hormone – dwarfism
• Excessive Growth Hormone – gigantism, acromegaly
• Insufficient Thyroid Hormone – delays bone growth
• Sex Hormones – promote bone formation; stimulate ossification
of epiphyseal plates
• Physical Stress – stimulates bone growth
15
Animation:
Bone Growth in Width
16
7.4: Bone Function
17
Support, Protection,
and Movement
• Support, Movement & Protection
• Gives shape to head, etc.
• Supports body’s weight
• Protects lungs, etc.
• Bones and muscles interact
• When limbs or body parts move
18
Blood Cell Formation
19
Inorganic Salt Storage
• Inorganic Salt Storage
• Calcium
• Phosphate
• Magnesium
• Sodium
• Potassium
20
7.5: Skeletal Organization
• The actual number of bones in the human skeleton
varies from person to person
21
Divisions of the Skeleton
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Cranium
• Skull Hyoid
Clavicle
• Spine Scapula
Sternum
Ribs
Vertebral Vertebral
column column
• Appendicular Skeleton
Hip
Carpals bone
Sacrum
Radius
Coccyx
• Upper limbs
Ulna
Fibula
Tarsals
Metatarsals
Phalanges 22
(a) (b)
7.6: Skull
23
Cranium
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Roofs of orbits
Lacrimal bone
Ethmoid bone
Maxilla
Mandible
Mental foramen
24
Cranium
• Parietal Bones (2) Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Squamous suture
Sphenoid bone
Styloid process
Mental foramen
Zygomatic process
of temporal bone Mandible
Coronoid process
25
Cranium
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Base of cranium
Palatine process of maxilla
Zygomatic bone
Median palatine suture
• Foramen magnum Frontal bone
Sphenoid bone
Palatine bone
• Lambdoidal suture
Vomer bone
Foramen lacerum
Mandibular fossa
Foramen ovale
Styloid process
Foramen spinosum
External acoustic meatus
Carotid canal
Jugular foramen
Stylomastoid foramen
Occipital condyle
Foramen magnum
Mastoid foramen Lambdoid suture
Temporal bone
Condylar canal
Occipital bone
26
Cranium
• Temporal Bones (2) Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Frontal bone
• Mandibular fossa
Temporal bone
Zygomatic bone
• Mastoid process
Temporal process
External acoustic meatus
of zygomatic bone
Mandibular condyle
Maxilla
Coronoid process
27
Cranium
• Sphenoid Bone (1)
• Base of cranium Lesser wing
Optic canal
• Sides of skull
Greater
wing
Greater wing
Superior
orbital fissure
Foramen
rotundum
28
Cranium
• Ethmoid Bone (1)
• Roof and walls of nasal cavity
• Floor of cranium
• Wall of orbits
• Cribiform plates
Perpendicular
plate Crista galli
• Ethmoid sinuses
Orbital
surface
Perpendicular
• Crista galli
plate
(a) (b)
29
Facial Skeleton
• Maxillary Bones (2) Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Frontal bone
• Maxillary sinuses
of zygomatic bone
Mastoid process
• Palatine process
Maxilla
Mandibular condyle
Styloid process
Mental foramen
Zygomatic process
of temporal bone Mandible
Coronoid process
30
Facial Skeleton
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Frontal sinus
Ethmoidal sinuses
Sphenoidal sinus
Maxillary sinus
31
Facial Skeleton
• Palatine Bones (2)
• ‘L’ shaped bones located
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
behind the maxillae
• Posterior section of hard
palate
• Floor of nasal cavity
Perpendicular
• Lateral walls of portion
nasal cavity
Coronal section
Horizontal portion
32
Facial Skeleton
• Zygomatic Bones (2) Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Frontal bone
Zygomatic bone
Temporal process
External acoustic meatus
of zygomatic bone
Styloid process
Mental foramen
Zygomatic process
of temporal bone Mandible
Coronoid process
33
Facial Skeleton
• Lacrimal Bones (2) Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Frontal bone
cavity Squamous suture
Sphenoid bone
Occipital bone
Ethmoid bone
Lacrimal bone
• Bridge of nose
Nasal bone
Temporal bone
Zygomatic bone
Temporal process
External acoustic meatus
of zygomatic bone
Styloid process
Mental foramen
Zygomatic process
of temporal bone Mandible
Coronoid process
34
Facial Skeleton
Squamous suture
Sphenoid bone
Crista galli
Internal acoustic meatus
Cribriform plate
Ethmoid
bone Perpendicular plate Jugular foramen
(nasal septum)
Sella turcica
Inferior nasal concha
Palatine process Hypoglossal canal
of maxilla
Styloid process Foramen magnum
Palatine bone
Vomer bone
35
Facial Skeleton
• Inferior Nasal Conchae (2) Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Temporal bone
Squamous suture
Sphenoid bone
Crista galli
Internal acoustic meatus
Cribriform plate
Ethmoid
bone Perpendicular plate Jugular foramen
(nasal septum)
Sella turcica
Inferior nasal concha
Palatine process Hypoglossal canal
of maxilla
Styloid process Foramen magnum
Palatine bone
Vomer bone
36
Facial Skeleton
• Mandible Bone (1)
• Lower jaw Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Body
Coronoid Coronoid process
process
Mandibular
• Ramus
foramen Mandibular condyle
• Mandibular condyle
• Coronoid process
Ramus
Alveolar
• Alveolar process
Mandibular
border
foramen
Body
• Mental foramen
(b)
37
Infantile Skull
• Fontanels – fibrous membranes
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Frontal suture
(metopic suture)
Frontal bone
Anterior fontanel
Sagittal suture
Posterior fontanel
(b)
38
7.7: Vertebral Column
39
Vertebral Column
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Vertebra
Intervertebral
foramina Lumbar
Lumbar vertebrae
curvature
Sacrum
Sacral
curvature
Coccyx 40
(a) (b)
Vertebral Column
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Vertebra
prominens
• Lumbar curvature
• Sacral curvature Rib facet
• Vertebral prominens
Thoracic vertebrae
curvature
Sacrum
Sacral
curvature
Coccyx 41
(a) (b)
Typical Vertebrae
• Includes the following parts:
• Vertebral body
• Pedicles
• Lamina
• Spinous process
• Transverse processes
• Vertebral foramen
• Facets
42
Cervical Vertebrae
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head
• Transverse foramina Transverse
process
Transverse
foramen
Body
Inferior articular
process Transverse
process
Dens (odontoid
Axis
(b) (c) process)
43
Thoracic Vertebrae
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Superior
articular
• Long spinous processes process
Pedicle
Transverse
• Rib facets process
Facet for Body
tubercle of rib Intervertebral notch
Superior Body
articular
process Inferior articular
Spinous
Transverse process
process
process
(a)
Inferior articular Spinous process
process Lamina
Intervertebral Transverse process
disc
Facet for tubercle of rib
Vertebral foramen
Spinous Anterior
Pedicle
process
Body
(b) 44
Posterior
(c)
Lumbar Vertebrae
• Large bodies
• Thick, short spinous
processes
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Spinous process
Lamina
Superior articular
process
Transverse process
Pedicle Vertebral foramen
Body
• Posterior sacral
foramina Sacral promontory Superior articular process Sacral canal
Posterior sacral
the apex foramen
Sacral hiatus
Anterior sacral
foramen
Coccyx
(a) (b)
46
Coccyx
• Aka tailbone Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Auricular
surface
Sacrum Tubercle
of median
sacral crest
Posterior sacral
foramen
Sacral hiatus
Anterior sacral
foramen
Coccyx
(a) (b)
47
7.8: Thoracic Cage
48
Thoracic Cage
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Jugular notch
(suprasternal notch)
1
Thoracic vertebra
Clavicular notch
• Sternum 3
2
Manubrium
5 Body Sternum
• Costal cartilages 6
7
Xiphoid process
9
Ribs
ribs Costal
• Protects viscera
12
Floating ribs
(vertebral ribs)
• Role in breathing
(a)
49
(b)
b: © Victor B. Eichler, PhD
Ribs
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Jugular notch
(suprasternal notch)
Thoracic vertebra
1 Clavicular notch
• Floating (2) 6
7
Xiphoid process
8
Ribs
Vertebrochondral 9
50
(b)
b: © Victor B. Eichler, PhD
Rib Structure
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Shaft Head
Neck
vertebrae (a)
Spinous process
Tubercle
cartilage
Neck
Head
Facet
Shaft
Anterior end
(b) (sternal end)
51
Sternum
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Jugular notch
(suprasternal notch)
1
Thoracic vertebra
Clavicular notch
sternum: 3
2
Manubrium
5 Body Sternum
• Body 6
7
Xiphoid process
9
Ribs
(a)
52
(b)
b: © Victor B. Eichler, PhD
7.9: Pectoral Girdle
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Head of
shoulder girdle humerus
• Clavicles Coracoid
• Scapulae
process
Ulna
Radius
(a)
53
Clavicles
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• A-C joint
process
Sternum
Costal
Scapula Rib cartilage
Humerus
Ulna
Radius
(a)
54
Scapulae
• Spine • Acromion process
• Supraspinous fossa • Coracoid process
• Infraspinous fossa • Glenoid fossa or cavity
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Superior
border
Coracoid
process
Suprascapular Acromion
notch process
Acromion Coracoid
process process
Supra-
Spine glenoid Glenoid
tubercle cavity
Glenoid
cavity Subscapular
Infra-
fossa
Supraspinous glenoid
fossa tubercle
Lateral
Infraspinous (axillary) border
fossa
Medial
(vertebral)
border
(a) (b) (c) 55
7.10: Upper Limb
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Humerus Humerus
• Radius
Humerus Olecranon Olecranon
process fossa
Head of radius
• Ulna Ulna
(c)
Neck of radius
(Interosseous membrane)
• Carpals
• Metacarpals Radius
• Phalanges Ulna
Ulna
Carpals
Metacarpals
Phalanges
Anatomical
• Greater tubercle Intertubercular
groove neck
• Anatomical neck
• Surgical neck
• Deltoid tuberosity Deltoid tuberosity
• Capitulum
• Trochlea
• Coronoid fossa
• Olecranon fossa
Coronoid Olecranon
fossa fossa
Lateral
Lateral
epicondyle
Medial epicondyle
epicondyle
Capitulum
Trochlea
57
(a) (b)
Radius
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Head of radius
• Radial tuberosity Olecranon
process
• Styloid process Radial tuberosity Trochlear
notch
Coronoid
process
Radial
notch
Radius
(b)
Ulna
Head of ulna
Styloid process
Styloid process Ulnar notch of radius
58
(a)
Ulna
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Head of radius
• Olecranon process Olecranon
process
• Coronoid process Radial tuberosity Trochlear
notch
Radius
(b)
Ulna
Head of ulna
Styloid process
Styloid process Ulnar notch of radius
59
(a)
Wrist and Hand
• Carpal Bones (16 total bones) Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Scaphoid Radius
• Lunate Scaphoid Ulna
Lunate
Scaphoid
Capitate Capitate
• Triquetral Trapezoid
Hamate
Triquetrum
Trapezoid
• Pisiform Trapezium
Pisiform
Trapezium
• Hamate Carpals
• Capitate (carpus)
• Trapezoid 1
5
1
Metacarpals 5
• Trapezium (metacarpus)
2
3 4 4 3
2
60
7.11: Pelvic Girdle
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Ilium
Sacral hiatus
Ischium
Obturator foramen
(b) Pubis
Sacroiliac joint
Ilium
Sacral promontory
Sacrum
Acetabulum
Pubis
Pubic tubercle
Symphysis
Ischium
pubis
Pubic arch 61
(a)
c: © Martin Rotker (c)
Hip Bones
• Also known as the coxae:
• Acetabulum
• There are three (3) Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Iliac spines
Ilium superior
Anterior iliac spine
3. Pubis Ischial
tuberosity
• Symphysis pubis
• Pubic arch
62
Greater and Lesser Pelves
• Greater Pelvis Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Abdominal wall
anteriorly Symphysis pubis
63
(b) Male pelvis Pubic arch
Differences Between
Male Female Pelves
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Female pelvis
• Iliac bones more flared Flared ilium
• Broader hips
Sacral promontory
• Lighter bones
• Why?
Sacral promontory
Sacral curvature
64
(b) Male pelvis Pubic arch
7.12: Lower Limb
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Femur Femur
• Patella Femur
Patella
• Tibia Fibula
• Fibula Tibia
• Tarsals Patella
(c) Lateral view
• Metatarsals
• Phalanges Fibula
Femur
Tibia
Lateral
Medial condyle
condyle
Fibula
Tibia
Tarsals
(d) Posterior view
Metatarsals
65
Phalanges
(b)
Femur
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Fovea capitis
• Neck
Greater
trochanter Gluteal
tuberosity
• Lesser trochanter
• Linea aspera Linea
aspera
• Condyles
• Epicondyles
Lateral Medial
epicondyle epicondyle
Medial Lateral
condyle condyle
Intercondylar
fossa 66
Patellar
(a) surface (b)
Patella
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Aka kneecap
• Anterior surface of the knee Femur
joint Femur
Patella
Fibula
Femur
Tibia
Lateral
Medial condyle
condyle
Fibula
Tibia
Tarsals
(d) Posterior view
Metatarsals
67
Phalanges
(b)
Tibia
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Condyles
Head of
tuberosity
fibula
• Anterior crest
crest
Medial
Lateral
malleolus 68
malleolus
Fibula
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Intercondylar
• Lateral to tibia Lateral
eminence
Medial
• Non-weight bearing
Fibula
Tibia
Medial
Lateral
malleolus 69
malleolus
Foot
• Tarsal Bones (14)
• Calcaneus
• Talus Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
• Navicular Fibula
• Cuboid Tibia
• Proximal
• Middle
• Distal
70
Foot
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Calcaneus
Talus Tarsals
(tarsus)
Navicular
Cuboid
Lateral cuneiform
Intermediate cuneiform
Medial cuneiform
5
4
3 Metatarsals
2 1
(metatarsus)
Proximal phalanx
Middle phalanx
71
(a)
7.13: Lifespan Changes
• Decrease in height at about age 30
• Calcium levels fall
• Bones become brittle
• Osteoclasts outnumber osteoblasts
• Spongy bone weakens before compact bone
• Bone loss rapid in menopausal women
• Hip fractures common
• Vertebral compression fractures common
72
Animation:
Osteoporosis
73