CHORIOCARCINOMA, A RARE CAUSE OF

ANTEPARTUM AND POSTPARTUM Article 5, group 2

HAEMORRHAGE, REPORT OF A CASE AND
REVIEW OF LITERATURE
ARTICEI IDENTITY
A. Title: Choriocarcinoma, A rare Cause of
Antepartum and Postpartum Haemorrhage, Report
of A Case and Review of Literature
B. Journal: International Journal of Gynecology &
Clinical Practices
C. Volume and Pages in journal: 118
D. Year: 2016
E. Writer: Fredick Hobenu, Simon Naporo, Leonard
Derkyi-Kwarteng and Patrick Kafui Akakpo
F. Reviewer: Risda Yuniarti and Ani Kurnia Liriahaq
ARTICLE HISTORY

Received February 06, 2016

Accepted May 17, 2016
Published May 19, 2016
AIM

To present a case of choriocarcinoma as a cause of

antepartum haemorrhage and of severe and fatal
postpartum haemorrhage in a patient carrying her
pregnancy to term
SUBJECT

A 27 year old mother of three was rushed to the

obstetric emergency room on account of heavy
bleeding per vaginum and symptoms of anemia one
month after delivery through a Caesarean
hysterectomy.
METHOD

Report of A Case and Review of Literature

BACKGROUND

Choriocarsinoma was the fourth gynecological cancer

cause of death after cancer of the cervix, ovary and
endometrium.
 CASE REPORT
A 27 year old mother of three bleeding per vaginumand symptoms of anaemia one month

Nine days after admission

The patient developed sudden onset of severe headache, was said to be agitated with slurred
speech, right facial palsy and left hemiplegia. Her chest had scattered bilateral basal
crepitations. Her BP was 100/40mmHg. Her neck was supple and Kernig’s sign was negative.
Internal examination showed
multiple nodules, some
haemorrhagic, ranging in size
from 3mm to 2cm across,
distributed in the parenchyma of
all lung lobes and on the pleural
surfaces of both lungs.
There was a right intracerebral
cerebral haemorrhagic lesion,
8cm across with liquefactive
necrosis of the surrounding brain
tissue with haemorrhage
extending into the subarachnoid
space

Abnormal bleeding per vaginam
Or
Tumor metastasis to other organ
such as the lung or brain
Haemoptysis or stroke
Chest X-ray
Chest computed
tomography
CHORIOCARSINOMA
Histopathological and Such high-risk choriocarcinoma is
ẞHCG treatedwith multiagent chemotherapy.
The preferred agents used for the
treatment of such high risk
choriocarcinoma are EMACO
(Etoposide, MTX, ACT-D,
Cyclophosphamide, and Vincristine),
Evaluated lung metastasis Aided immensely in
the diagnosis and
early management
Detect micrometastases
CONCLUTION

Choriocarcinoma is a rare cause of postpartum

intracerebral haemorrhage, antepartum haemorrhage
and postpartum haemorrhage and a high index of
suspicion is required to diagnose the condition with
readily available βhCG and histopathology. Once
diagnosed however, current chemotherapy regimens
assure a favourable prognosis. If not diagnosed early
however, it is rapidly fatal
STRENGHT AND LIMITATION

Strength Limitation
1. Verbal consent was 1. In institution, ethical
however sought from clearance is not required
the relations. to report clinical cases
2. Fresh article once all identifiers have
been removed from the
3. Article easy to know report
and understand
4. Case Report
Thank you