GOUT

MSC-I
PAPER I UNIT 3
ROLL NO-27
 GOUT INFLAMMATORY DISEASE
“GOUTY ATTACK” too much uric acid in the blood

MONOSODIUM URATE HYPERURICEMIA

crystals deposit in JOINTS Formation of
sharp particles
JOINTS(&Kidneys)
RED, HOT, TENDER
& SWOLLEN
Arthritis
PURINES PYRIMIDINES

Nitrogen HETEROCYCLE
Containing Different Molecular
atoms Ring
PURINES NUCLEIC
ACID
(e.g. DNA)

URIC ACID URINE

 HYPERURICEMIA
Greater than
HYPERURICEMIA
INCREASED DECREASED
CONSUMPTION Of CLEARANCE Of
Purines
Uric acid
MONOSODIUM URATE
*SHELLFISH
CRYSTALS *Dehydration
*ANCHOVIES
*RED MEAT -not enough water
*ORGAN MEAT. -Alcohol consumption.

OBESITY AND DIABETES

INCREASED CHEMOTHERAPY
PRODUCTION AND RADIATION
Of PURINES. GENETIC PREDISPOSITION

*High-Fructose CHRONIC KIDNEY DISEASE

Corn syrup beverages MEDICATIONS~THIAZIDE DIURETICS & ASPIRIN
 First metatarsal
joint of big toe

Podagra

• Wakes up feeling like

toe on fire
• Pain most severe in
hours after attack.
• Can last days- weeks

INFLAMMATION
Caused by WHITE BLOOD CELLS
TREATMENT
• ~DECREASE PAIN & SWELLING
• * NON- STERIODAL ANTI- INFLAMMATORY (NSAIDS)
eg: Ibuprofen & naproxen sodium.
• CORTICOSTERIODS
• COLHCHICINE~ Inhibits WBC migration
• ~ UNDERLYING CAUSE
*DIET MODIFICATION
* STAY ACTIVE
TREATMENT
• ~ DECREASE URIC ACID LEVELS
* XANTHINE OXIDASE INHIBITORS

• URICOSURIC MEDICATION
*PROBENECID
*INCREASED EXCRETION OF URIC ACID
REPEATED GOUTY
ATTACKS .

CHRONIC GOUT
*arthritis

*Tissue destruction
*increased risk of
~ kidney stones
~ Urate Nephropathy
~crystals in kidney
interstitium
REFERENCES
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512152/
• https://arthritis-
research.biomedcentral.com/articles/10.1186/ar3199
THANKYOU!