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Micromorphology - viruses

HEF
(human embryonic fibroblasts)
negative cell culture
HELA
negative cell culture
Green monkey kidney
negative cell culture
Enterovirus GMK

Pyknosis and cell lysis


Adenovirus HELA
Spiderweb
Cells become rounded
and the cell sheet
disintegrates – dark
basophilic inclusion
within the nuclei
represents accumulated
viral proteins
Herpes SV GMK

Prominent foci of
rounded cells
CMV HEF
Characteristic eosinophilic owl-
eye inclusions in the nuclei of
infected cells
Paramyxovirus
syncytium

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