Beruflich Dokumente
Kultur Dokumente
Contraception
Patient Counseling and Management
1. Kaunitz AM. 2007Feb7. 44 PowerPoint slides. 9. Lethaby AE, et al. Cochrane Database Syst Rev.
2. Davis AR, et al. Obstet Gynecol. 2005;106:97-104. 2005;4.
3. Edelman A. In: Practical gynecology: a guide for the 10. Arowojolu AO, et al. Cochrane Database Syst Rev.
primary care physician; 2008. 2004;3.
4. Hatcher RA, et al. Contraceptive Technology; 2004. 11. Best KA, et al. In: Gynecology for the primary care
5. Fedele L, et al. Fertil Steril. 1997;68(3):426-429. physician; 2007.
6. Hubacher D, et al. Obstet Gynecol Surv. 12. Kaunitz AM. Am J Obstet Gynecol. 2001;
2002;57(2):120-128. 185:S32-S37.
7. Davis A, et al. Obstet Gynecol. 2000;96:913-920. 13. Kaunitz AM. N Engl J Med. 2008;358:1262-1270.
8. Marjoribanks J, et al. Cochrane Database Syst Rev.
2006;2.
Hormonal Contraceptives
Combination hormonal – pill, patch, vaginal ring
– Oral contraceptives are the most commonly used
method in the US1
– Available in various dose and cycle combinations of
estrogen and progestin
Progestin-only – pill, long-acting/depot injection,
implant, levonorgestrel IUD
– Candidates include women with cardiovascular risk
factors, diabetes, lipid disorders, estrogen-related
side effects, migraine headaches,2 are post-partum
or breastfeeding3
Breast Cancer
– Large British2, US2,3, and Canadian4
studies found no increased risk with
former or current use
– Results are inconsistent from
studies of OC use among
BRCA-positive women5,6
1. Hatcher RA, et al. Contraceptive Technology; 2004.
2. Hannaford PC, et al. Br Med J . 2007;335:651-660.
3. Marchbanks PA, et al. N Engl J Med. 2002;346(26):2025-2032.
4. Silvera SA, et al Cancer Causes Control. 2005;16(9):1059-1063.
5. Milne RL, et al. Cancer Epidemiol Biomarkers Prev. 2005;14(2):350-356.
6. Narod SA, et al. J Natl Cancer Inst. 2002;94(23):1773-1779.
Combination Oral Contraceptive
Health Risks
Cervical Neoplasia
Data from 24 epidemiological studies involving
26 countries showed almost double the risk for
invasive cervical cancer in women taking OCs for
five or more years1
After stopping OCs, at 10 years the risk declined to
same as never users1
Reanalysis found other factors to be: younger age at
first intercourse, younger age at first full-term
pregnancy, increasing parity, increasing number of
sexual partners, and increasing duration of OC use2
VTE Incidence
10 - 15 95 - 96 511
per 100,000 Woman-Years
1. World Health Organization Collaborative. Lancet. 5. Best KA, et al. In: Gynecology for the primary care
1996;348:505-510. physician; 2007.
2. Lidegaard Ø, et al. Contraception. 2002;65(3):197- 6. World Health Organization Collaborative. Lancet.
205. 1996;348:498-505.
3. Siritho S, et al. Stroke. 2003;34(7):1575-1580. 7. Godsland IF, et al. N Engl J Med. 1990;323:1375-
4. Schwartz SM, et al. Stroke. 1998;29(11):2277-2284. 1381.
Contraceptive Patch and Ring
Alternative combined
hormone delivery systems,
used on a 28-day cycle
– 1 patch applied
weekly x 3, then removed
for one patch-free week
– 1 ring inserted and left
for 3 weeks, then removed for one ring-free week
Time to achieve steady state hormone levels - back-up
contraceptive may be needed1-3
1. Best KA, et al. In: Gynecology for the primary care physician; 2007.
2. Black A, et al. J Obstet Gynaecol Can. 2004;26(3):220-236.
Counseling for Hormonal
Contraception
OC Side Effects
Unscheduled bleeding continuing after 3 months of OC
use, should be evaluated for other potential causes,
including cervical or endometrial infection or neoplasia,
pregnancy, polyps, fibroids, or use of medications that
interfere with estrogen metabolism (e.g., smoking,
antiepileptics, rifampin, St. John’s Wort)1
Chlamydial cervicitis has been reported as a cause of late-
onset unscheduled bleeding in OC users2
If prolonged spotting/bleeding (ie, seven days or more) on
an extended use OC, take a 3-day pill holiday; this is more
effective than continuing the contraceptive3
1. Hatcher RA, et al. Contraceptive Technology; 2004.
2. Krettek JE, et al. Obstet Gynecol. 1993;81(5 Part 1):728-731.
3. Best KA, et al. In: Gynecology for the primary care physician; 2007.
Counseling for Hormonal
Contraception
OC Side Effects
Some long-term OC users
may experience amenorrhea,
which is not medically
harmful
Inadvertent use of OCs
during early pregnancy is
not associated with an
increased risk for fetal
anomalies or miscarriage
There are no consistent data to suggest associations
between weight gain or headaches and OC use
If problems or noncompliance due to side effects, a
formulation adjustment can be made
Barrier Methods
Have assumed greater importance in recent
years due to their ability to reduce the risk of
sexually transmitted infections
Are commonly used with other methods of
contraception, e.g., with OCs – the pill and
condom are the most common contraceptive
method combination1
Particularly appropriate for women in stable
relationships who can predict when they will
have intercourse
1. How Do You Use the Today® Sponge. Synova Healthcare Inc.; 2007.
2. Kuyoh MA, et al. Cochrane Database Syst Rev. 2002;3.
Barrier Methods
Spermicides
Chemical contraceptive barrier:1 surfactants (nonoxynol-9,
octoxynol-9) that destroy sperm’s cell membrane
Recommended to be inserted into the vagina no more than
1 hour before intercourse; should be kept in place at least
6-8 hours afterwards2
Failure rate during the first year of typical use of
spermicides alone is approximately 29%
Efficacy may be dose-related, based on concentration
of spermicide3
Spermicides do not protect against STIs and HIV4
1. ACOG Education Pamphlet; 2003Feb.
2. Birth Control Guide. FDA Office of Public Affairs; 2003Dec.
3. Raymond EG, et al. Obstet Gynecol. 2004;103:430-439.
4. FDA News. U.S. Food and Drug Administration; 2007Dec18.
Intrauterine Devices (IUDs)
Highly effective; convenient;
have non-contraceptive benefits1,2
Two IUDs are available
in the US:
– Copper T 380A – for up to
10 years of use; cumulative
ten-year pregnancy rate
is about 2%3
– Levonorgestrel-releasing IUD –
for up to 5 years of use;
cumulative five-year pregnancy rate is <1% 4
Can be inserted at any time in the menstrual cycle, provided the
woman is not pregnant
1. Liu XF, et al. Chin Med Sci J. 2005;20(1):35-39 5. Carolei A, et al. Lancet. 1996;347:1503-1506.
[abstract]. 6. Donaghy M, et al. J Neurol Neurosurg Psychiatry.
2. Stang PE, et al. Neurology. 2005;64:1573-1577. 2002;73:747-750.
3. Kurth T, et al. Neurology. 2005;64:1020-1026. 7. Tzourio C, et al. Br Med J. 1995;310:830-833.
4. Etminan M, et al. Br Med J. 2004Dec13. 8. MacGregor EA, et al. Neurology. 2006;67:2154-2158.
Contraception in
Women with Medical Problems
Migraines
The WHO1:
– Advocates caution (category 2 or 3) in the use of hormonal
contraception in migraineurs
– Disapproves use (category 3 or 4) in women older than 35
– Classifies those with aura as having unacceptable health risk
(category 4) for this method of contraception
In general, hormonal contraception is not contraindicated in
women with migraines, however need to review predisposing
factors and migraine patterns before prescribing
Appropriate alternatives include progestin-only, intrauterine
and barrier methods2