Beruflich Dokumente
Kultur Dokumente
Biotechnology II
Antibiotics Disrupt Cell Wall Synthesis,
Protein Synthesis, Nucleic Acid Synthesis
and Metabolism
Univ S. Carolina
Principles and Definitions
Selectivity
– Selectivity vs toxicity
Therapeutic index
– Toxic dose/ Effective dose
Categories of antibiotics
– Bacteriostatic
Reversibly inhibit growth
Duration of treatment sufficient for host defenses to
eradicate infection
– Bactericidal-
Kill bacteria
Usually antibiotic of choice for infections in sites such as
endocardium or the meninges where host defenses are
ineffective.
Principles and Definitions
Selectivity
Therapeutic index
Categories of antibiotics
– Use of bacteriostatic vs bactericidal
antibiotic
Therapeutic index better for bacteriostatic
antibiotic
Resistance to bactericidal antibiotic
Protein toxin mediates disease – use
bacteriostatic protein synthesis inhibitor to
immediately block synthesis of toxin.
Principles and Definitions
Antibiotic susceptibility testing (in vitro)
– Bacteriostatic Antibiotics
Minimum inhibitory concentration (MIC)
Lowest concentration that results in inhibition of visible
growth (colonies on a plate or turbidity of liquid culture)
– Bactericidal Antibiotics
Minimum bactericidal concentration (MBC)
Lowest concentration that kills 99.9% of the original inoculum
Antibiotic Susceptibility Testing-MIC
Disk Diffusion Test
Determination of MIC
Str
Tet Ery
8 4 2 1 0 Chl Amp
Tetracycline (g/ml)
MIC = 2 g/ml