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Spinal Cord
Nociceptor Gottschalk A et al. Am Fam Physician. 2001;63:1979-84.
Fields HL et al. Harrison’s Principles of Internal Medicine. 1998:53-8.
Stage of Nociception
1. Transduction Conversion of noxious stimuli
(mechanical, thermal, chemical into
electrical activation
2 Transmission Communication of the nerve impulse
from the periphery to the spinal cord,
up to spinothalamic track to the
thalamus and cerebral cortex
Medulla
Pain
Samad TA et al. Nature. 2001;410:471-5.
Pendahuluan
VR1
Voltage-Gated
Extern •Heat Ca2+ Sodium
Channels
al •Mechanical
•Chemical Action
Stimuli Potentials
External Stimulus
VR1
HEAT
PK
Sensitizing Stimulus EP A
Recept SNS/PN3
PGE or
2 PKCeTTX-Resistant
Sodium
Bradykinin Channel
BK
Recept
or
Large A
fibers
Dorsal root
ganglion Dorsal Horn
A
Small
fibers
C Peripheral sensory
Nerve fibers
Physiological Pain
NOXIOUS INNOCUOUS
STIMULUS STIMULUS
A C fiber A
DHN DHN
INNOCUOUS SENSATION
PAIN
Touch
First Pain
Tactile
Second Pain
Pressure
Jaras nyeri di MS dan batang otak
Dari kornu dorsalis menuju otak, sinyal nyeri
disalurkan di MS melalui:
☻Tr. Neo-spinotalamikus
- untuk nyeri cepat berakhir di lamina I
(lamina marginalis) – kolumna anterolat.
- sebgn berakhir di kompleks ventrobasal
dan sebgn lagi di korteks somatosensorik
Jaras nyeri di MS dan batang otak
☻Tr. Paleo-spinotalamikus
- utk nyeri lambat dan khronik melalui saraf tipe C
dan sebgn saraf tipe Aδ
- berakhir di lamina II dan III subs. Gelatinosa dan
lamina V dan VII kornu dorsalis
- Neurotransmiternya Subst. P dan Glutamat
- Berakhir di tiga tempat
■ Nc. Retikularis medula, pons dan mesensefalon
■ Area tekt. mesensefalon dan kol. Sup dan Inf
■ Subst. grisea peri akuadukt
Activation of Central Neurons
C-Fiber Terminal
Glutamate
(-)
P
NMD
Substance P A
P
AMPA
Ca2+
(+) Dorsal Horn Neuron
(+) PKC