1 Formulation and Evalution of Metronidazole Emulgel Using

Different Polymer For Bacterial vaginosis

Under the Guidance of Presented by

Dr. G.Gnanarajan Deepak Chandra Sharma
Assistant Professor
Department of Pharmaceutical Sciences
2 Why Topical Drug Delivery System ?

Topical drug delivery system is recognized as one of the most important and
reliable alternative to the oral and parenteral drug delivery system.
TDDS includes the patches, gels, emulgel, microemulsion, nanoparticles,
liposomes, niosomes, etc.
The NSAID’s, antifungals, antibacterial, antivirals drugs can be given through
the TDDS.
Advantages of TDDS:
 Avoidance of first pass metabolism.
 Convenient and easy to apply.
 Avoidance of gastro-intestinal incompatibility.
 A relatively large area of application in comparison with buccal or nasal
cavity.
3 Emulgel

Definition:-
When gel and emulsion are used in combined form the dosage form are referred as
‘Emulgel’.
 4

 In spite of many advantages of gels a major limitation is in the delivery of hydrophobic drugs. So
to overcome this limitation emulgels are prepared and with their use the hydrophobic drugs are
delivered.
 Both o/w and w/o emulsions are used as vehicles to deliver various drugs to the skin.
 Emulsion itself is a controlled release system where entrapped drug particles in internal phase
pass through the external phase to the skin and slowly get absorbed. Internal phases act as
reservoir of drug and slowly release drug in a controlled way through the external phase to the
skin. Gel forms cross linked network where it captures small drug particles and provides its
release in a controlled manner.
5

 Due to its bioadhesive property it prolongs the contact period of medication

over the skin. Since emulgel possesses the property of both emulsions and gel,
it acts as dual control release system.
 Depending on the type of emulsion used to prepare emulgel, they are referred
as macroemulgel, microemulgel, nanoemulgel.
 Various categories of drug such as NSAIDS, antifungal, antibacterial, antiviral
etc. are used for preparation of emulgel.
6 Advantages

Hydrophobic drugs can be easily incorporated into gels using emulsions.

Better stability.

Better drug loading capacity.

Controlled release, medication can be terminated when needed.

Avoidance of first pass metabolism.

7 Rational

 Because, many widely used topical agents like ointments, creams,

lotions have many disadvantages. They are sticky in nature causing
uneasiness to the patient when applied, have lesser spreading coefficient
so applied by rubbing and they also exhibit the problem of stability.
 Need for Study
8

 Oral administration of Metronidazole is associated with severe gastric irritation

therefore to overcome this problem emulsion based gel form was formulated.
 Emulgel overcomes the problems associated with emulsion (i.e. stability) and gel
(i.e. syneresis) alone.
 Bacterial vaginosis is a common condition.it is a bacterial infection of the vagina
and is caused by an overgrowth of normal bacteria.
 it can be treated with an antibacterial gel such as metronidazole.
 Oil phase Aqueous phase

 9

Emulsification

O/W or W/O Emulsion

Incorporation in to gel base

Emulgel

 Method of prepration
 Evaluation of Emulgel
10
 Appearance
 pH
 Viscosity
 Drug content
 Spreadability
 Swelling Index
 diffusion study
 Skin irritation study
 Stability study
11
Marketed Products of Emulgel

Brand Name Active ingredient Mfg. Company

Voltarol Diclofenac diethyl Novartis

Diclomax Diclofenac sodium Torrent pharma

Miconaz-H Miconazole nitrate Medical union

pharmaceuticals
Denacine Clindamycin phosphate Beit jala pharmaceutical

Isofen Ibuprofen Beit jala pharmaceutical