Guided by: Mr. Vipul patel Prepared by: Adhiya Jinal Y.

Department of Pharmaceutics UID: 13SOPPH11001

School of Pharmacy Roll no. 1
RK University 8th sem B.Pharm
Intro. to Mucosal drug delivery system
Intro to BDDS
Difference between buccal and sublingual delivery
Types of buccal formulation
diseases Managed via buccal route
Formulation components
Ideal characteristics
Merits and Demerits
Evaluation parameters
Marketed formulation
Live demonstration and Activity
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 Uterine Bioadhesive

Mucosal
Delivery
Vaginal Sublingual

Nasal Mouth
Delivery dissolving

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 Drug System
• Related • To give/
• Medicament • To
to cheek Apply Organize

Buccal Delivery

“Delivery of drug through Buccal mucosa of oral cavity is called BUCCAL

DRUG DELIVERY SYSTEM”

Placed between cheek and gums

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 Sublingual
Tablet

Buccal Tablet
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 BDDS

Solid Semi-solid Liquid

Tablets Gels Sprays

Patches/Films Ointments

Lozenges

Powders

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 Ulcerative gingivitis

syphilis

Oral candidiasis

Ulcers

Diabetes

Herpes viral infection

Gingival hyperplasia

Chronic Heart conditions

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 Video

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 Mucoadhesive Permeation Super
API Diluents Plasticizers
Polymer enhancers disintegrants

Chelators Sod. starch

Insulin Pectin Lactose PEG 400 glycolate
•EDTA
•Sodium salicylate

Propylene Cross
calcitonin HPMC E15 Mannitol carmellose
Glycol sodium
Fatty acids
•Oleic acid
Methyl
•Lauric acid
vasopressin acrylate Sorbitol
{Eudrajit}

surfactants
Piroxicam carbopol •SLS
•Benzalkonium
chloride

Triamcinolone

Acyclovir

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 Drug Excipients
MW less than 1000 Da Non-toxic and non-irritant

Both Hydrophilic and lipophilic Sufficient Mechanical

Property strength
Easily incorporate the
Potent
drug in formulation
Do not alter the drug
Non-irritant to mucosa
release

Degrade in GIT Cost effective

Good solubility, wetting

property

Biodegradable

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 Merits Demerits
Drugs with bitter taste/irritant to
Avoids first pass metabolism
mucosa

Avoid Acid/Enzymatic metabolism Not for children

Faster permeation Eating and Drinking difficulty

Large surface area than sub-lingual Not for drugs – unstable at buccal pH
route (6.5 to 7)

Good patient compliance than parental

Salivary erosion- may enter to GIT
route

Easy to apply and remove in case of

toxicity
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 Viscosity
Weight
Hardness Friability Dissolution Disintegration (Semi-
variation
solids)

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 Thin Film

Muco-
Disintegration Texture
Adhesive
time analysis
Strength

Slide Frame Petri dish

Method method

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 Striant Asftach Cydot
DentiPatch
tablets Tablets patch

Lidocaine
Testosterone
Triamcinolone sustain release Melatonin
hormon
buccal patch

For
replacement in To provide Normalize
Ulcers
hypogonadal local analgesia cardiac rythms
men

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