Anxiety disorders anticipate the diagnosis of

bipolar disorder in comorbid

patients: Findings from an Italian tertiary
clinic
Valentina Caricasolea, Ilaria Di Bernardoa, Alberto Varinellia, Cesare Galimbertia,
Riccardo Zanelloa, Monica Bosia, Terence A. Ketterb, Caterina A. Viganòa,
Bernardo Dell'Osso

Oleh :
Zidnil Ula
Novia Safitri
Abdullah
Faridah Azzah Sari
Cory Dwi Rizki Oktavianti

PEMBIMBING : dr. Glorio Immanuel, Sp. KJ

KEPANITRAAN KLINIK RSUD DR. SOESELO

UNIVERSITAS MUHAMMADIYAH PURWOKERTO
 Identitas Artikel
Judul Anxiety disorders anticipate the diagnosis of bipolar disorder in
comorbid patients: Findings from an Italian tertiary clinic

Volume dan Volume 257, 5 Halaman (376-381)

halaman

Tahun 2019

Valentina Caricasolea, Ilaria Di Bernardoa, Alberto Varinellia, Cesare

Penulis Galimbertia,
Riccardo Zanelloa, Monica Bosia, Terence A. Ketterb, Caterina A.
Viganòa, Bernardo Dell'Ossoa,

Reviewer dr. Glorio Immanuel, Sp. KJ, Zidnil, Novia, Abdullah, Azzah, Cory
Tujuan To know the possibility of the presence of anxiety disorder
as an onset of bipolar disorder

Subjek 246 of bipolar patients

penelitian

Metode Retrospective study

penelitian

Faktor Panic disorder, exposure time and onset, family history,

Pengaruh depression, drug and substance usage

Alasan Know the importance of a careful and detailed diagnostic

dilakukan assessment, especially at first psychiatric evaluations of
penelitian patients with anxiety symptoms
Variabel Anxiety disorder
independent

Variabel
dependent Bipolar disorder
 Analyzed
retreospectively by
A total of 260 bipolar psychiatrists or 14 were out because of
patients residence between a missing data
2008-2015 (via medical
records)

Sample divided into

Compared analytically
patients with anxiety
using chi square tests
versus without anxiety
 More than one fourth (n=72, 29%,) of the sample had an AD at BD onset.
Hasil
penelitian PD was the most represented diagnosis among bipolar patients with AD at the onset.

Rates of family history for psychiatric conditions among first-degree relatives were high
among patients w/A
AD diagnosis occurred significantly earlier compared to the onset of BD

Patients w/A had significantly higher rates of BD II (as well as more frequent depressive
onset)
patients w/A more frequently had benzodiazepine abuse (while patients wo/A had alcohol
abuse)

Simpulan Anxiety disorder (in particular PD) preceded BD in almost 1/3 of BD outpatients

The progression from Anxiety disorder to Bipolar disorder may represent a continuous
process in which, Anxiety disorder could represent a prodromic phase within the bipolar
disorder course
Kelebihan Kekurangan
• The researcher • The researcher did not
explains detail the explain the reason for
comparison of his determining the study
research with previous period
research • recall bias due to the
• The reseacher explain retrospective nature of
about limitation of his the studies may have
research limited the quality of
assessment