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ANABOLICS

& ITS
USE

DR. VIPUL TRIVEDI


DISCLAIMER
Steroids carry numerous short-term risks
• high blood pressure,
• high cholesterol,
• liver toxicity
and long term risks
• atherosclerosis,
• infertility,
• hypogonadism, etc
dependent on compound use, the dosages and the duration taken.
•Hormones are chemical substance produced in the body that controls
and regulates the activity of certain cells or organs.
•Hormones are essential for every act of life, including the process of
digestion, metabolism, growth, reproduction and mood control.
•Hormones are chemical substances that act like messenger molecules in
the body. After being made in one part of the body, they travel to other
parts of the body where they help control how cells & organs do their
work.
Ex:- Insulin
•Hormones are often directly released into the blood stream, buy they
may also be secreted into ducts.
MEN HORMONE – TESTOSTERONE
Produced in testes and adrenal gland
•It not only drive Sexually but it Fuels energy, strength and ambition.
•Vital to men’s health
•Musculo-skeletal tone and strength
•Libido
•Sperm production
•Lean muscle mass
•Mood and outlook
In women, high testosterone can cause acne, unwanted hair on face and
body, polycystic ovaries, interferences in ovulation and aggression.
WOMEN HORMONE – OESTROGEN
Made in ovary, adrenal glands & fat cells
•It promotes growth of uterine lining during the first half of the
menstrual cycle
•Contributes to sexuality
•Prevent bone loss
•Maintain good cholesterol
In men – as men age & are more prone to weight gain,
conversion of testosterone into estrogen increases in fat cells.
•Fatigue
•loss of muscle tone
•even more weight gain
•decreased libido
•problems with the prostate
•increase risk of heart disease
•increased fat in the breast area
It is the 3rd sex steroid useful in sexual health. Produced in ovaries and
through ovulation.
It helps in:
•Balances the unwanted effects of estrogen
•Helps the body use fat for energy, maintaining healthy weight
•Prevents bloating
•Calms the body and mind
•Promotes restful sleep
•Protects against breast and uterine cancer

Balance between oestrogen & progesterone prevent PMS, mood swing,


weight gain, irregular cycles & hot flashes

In men, progesterone lifts the mood and encourage restful sleep. It uses fat
for energy, protect against prostate cancer. Overall, energy and strength is
improved in men who have adequate progesterone levels.
1. Estrogen – bane of male bodybuilders
2. Progestins – used in female contraceptives
3. Mineralocorticoids – control water balance
4. Glucocorticoids – anti-inflammatory compounds
5. Vitamin D
6. Bile acids
Prolactin: This is a protein that promotes milk production in the female body, and even worse,
if you abuse even in the male body. Prolactin causes a decrease in Luteinizing Hormone, and this
lowers testosterone.

Follicle Stimulating Hormone: This hormone (commonly referred to as FSH) is


agonadotropin, which is responsible for egg-cell-containing follicles in the female ovaries, and it
also stimulates follicular cells to secrete estrogen. In males, it helps stimulate the production of
sperm cells in the testes during puberty. It also may tell the testes to secrete testosterone, but
certainly influences the number of leydigs cells, which we secrete testosterone. .
Finally, FSH stimulates the production of Androgen Binding Protein in the Sertoli cells.

Luteinizing Hormone: This stuff (usually called LH, in shorthand) promotes the secretion of
sex hormones. We’re hoping to keep it high (or not let it get too low) so it keeps telling out
testes to secrete testosterone. Both LH as well as testosterone is secreted in pulses between eight
and fourteen times per day, testosterone being preceded by LH by approximately an hour.
Testosterone is, of course, controlled via a negative feedback loop, thus a higher level of
testosterone in your body causes a decrease in LH.
Steroids: These are compounds whose molecules contain fairly complex rings
of Carbon and Hydrogen atoms. Steroid hormones include (but are not limited
to) testosterone and estrogen, and we will be primarily concerned with those
two although we will examine many other hormones. Sometimes we use the
term “steroid” to mean anabolic steroid, which is only one possible type. Steroid
hormones (like testosterone) are soluble in the lipids that make up cell walls.
This means they can get into a cell and mess around with the receptors in the
nucleus, which is exactly what we want.

Receptor: This is a thing in the cell that is basically like a parking spot.When a
steroid hormone comes in, it’s like parking a car in that spot. The steroid
hormone then tells the cell to do something. If the hormone is testosterone, it
may tell the cell to “build more muscle!”

Androgen Receptor: This is the parking spot “reserved” for steroids like
testosterone and such, in other words, androgens.
Prostaglandins: Some of these regulate cellular responses to hormones and stimulate the
secretion of a variety of hormones.

Negative Feedback System (or loop): This is the system by which your body recognizes an
abundance of a particular hormone and consequently stops producing it. In simple terms, if you
are injecting testosterone, your body will sense this and stop producing its own.

Pituitary Gland: The anterior lobe of this secretes a variety of hormones such as growth
hormone, thyroid- stimulating hormone, prolactin, follicle-stimulating hormone, and luteinizing
hormone.You want to keep this thing healthy and happy.

Growth Hormone: Growth Hormone (GH) is a protein that stimulates your body’s cells to
undergo more rapid cell division. It enhances the movement of amino acids through cell
membranes and causes an increase in the rate in which they convert molecules to proteins and
decrease the rate they use carbohydrates and increase the rate they use fats. It is secreted in
rhythmic pulses, especially while you’re asleep and has an important anabolic effect on the body.

Growth Hormone-Releasing Hormone: This stuff is the hormone that releases growth
hormone.
Insulin: Insulin is a protein secreted by the pancreas that acts on the liver to stimulate
the formation of glycogen from glucose and inhibits the conversion of noncarbohydrates
into glucose.
Insulin-Like Growth Factor: Insulin-like growth factor is released from the liver in
response to GH. It has an important anabolic effect on the body.
Glucagon: This is a hormone that is produced in the pancreas and regulates blood
sugar levels. Unlike insulin, glucagon is released when blood sugar levels are low. It
causes the release of glucose from glycogen.
Thryoid Stimulating Hormone: This is a protein bound to a carbohydrate. It
controls the secretion of hormones from the thyroid gland.
Hypothalamus: This releases gonadotropin- releasing hormone, and also controls
most secretions of the pituitary gland, which leads me to the. ...
Pituitary Gland: This is where the Philosopher Rene’ Descartes thought the soul
lived. Actually, it’s much more important because it controls the secretion of LH and
FSH, and thus, the production of testosterone! It also controls secretion of GH and
thyroid stimulating hormone.
Hypothalamic-Pituitary-Testicular-Axis: This is usually called the HPTA,
and it basically regulates all of the hormones that stimulate the production of
testosterone as well as GH and other goodies. Needless to say, keeping your
HPTA in good working order is very important.

Aromatization: This is the process by which testosterone converts to


estrogen, via the aromatase enzyme. This occurs in various tissues, such as
skeletal muscle and adipose tissues. Also, you’ll experience less of this if you
have less adipose tissue (less fat on a cycle means fewer sides, believe it or not).

Dihydrotestosterone: This stuff, also called DHT, is made from testosterone


in your body via interaction with the enzyme 5-alpha-reductase, which adds 2
hydrogen atoms to testosterone. It has a variety of effects in the human body, and
is responsible for certain unwanted side effects such as hair loss. DHT interacts
strongly with the central nervous system, and has both anabolic as well as
androgenic effects.
•All anabolic steroids owe their existence to the steroidal hormone –Testosterone.

•This makes testosterone most important steroid of all.

•With no testosterone there are no anabolic steroids.

•Any testosterone form will stack well with any anabolic steroid.

•Other anabolic steroids may not stack well together but with testosterone you
can never go wrong.

•Both Steroids & testosterone can make you leaner, harder, increase athletic
performance and simply improve your overall life dramatically.
TESTOSTERONE – THE BASICS

 Testosterone is a 19-carbon steroid hormone produced by the


leydig cells of the testes (in men) and the ovaries(in women) and
smaller amounts in adrenal glands.
 Testosterone belongs to androgen class of hormones that also
includes
1. Dihydrotestosterone(DHT)
2. Dehyrdroepiandrosterone (DHEA)
3. Androstenedione
4. Androstendeiol
Growth of the penis, scrotum and testes during puberty
• Enlargement of the larynx (voice box) that results in a deepening of the voice
• Formation of functional sperm
• Stimulation of hair growth - especially in the pubic area, chest, face, and, sometimes,
the back
• Increases in skin thickness and darkness
• Increases in libido (sex drive)
• Increases in basal (resting) metabolic rate
• Increases in red blood cell number and total blood volume
• Promotion of sodium and water retention in the kidneys
• Increases in muscle protein synthesis resulting in increased muscle mass
• Reductions in muscle glycogen breakdown during exercise
• Increased calcium retention in bone
• Decreased growth of hair on top of the head
• Increased activity of the sebaceous (sweat) glands, sometimes resulting in acne
• Promote a narrowing and strengthening of the pelvis
Testosterone, the primary male sex hormone, is manufactured in the testes
under the influence of luteinizing hormone (LH) in amounts of 2.5-11 mg/d.
Testosterone is produced under a negative feedback loop between the
hypothalamus, the anterior pituitary, and the testes.

Testosterone, dihydrotestosterone, and estrogen all act at the hypothalamus to


exert negative feedback inhibition upon gonadotropin-releasing hormone
(GnRH).

Since GnRH stimulates follicle-stimulating hormone (FSH) and LH release in


the pituitary, this negative feedback can be seen to inhibit subsequent
testosterone production and effect spermatogenesis.
Testosterone activity is mediated via an androgen receptor that is present in
various tissues throughout the human body. Testosterone binds to an intracellular
receptor found in the cytosol of cells, forming a receptor complex that migrates
into the nucleus, where it binds to specific deoxyribonucleic acid (DNA)
segments. This, in turn, activates specific messenger ribonucleic acid (mRNA) to
increase transcription, leading to an increased rate of protein synthesis; in the
case of muscle cells, this means increased production of the proteins actin and
myosin.
After this process is complete, the receptor complex dissociates and is recycled
along with the hormone, to repeat this process multiple times prior to
metabolism.
These anabolic actions of testosterone are thought to be primarily due to
testosterone acting upon the androgen receptor in anabolic-responsive tissues.
Androgenic effects are likely mediated via the same androgen receptor in
androgen-responsive tissues under the influence of dihydrotestosterone (DHT),
which is produced by the interaction of 5-alpha reductase (5AR) with
testosterone and the subsequent reduction of the C4-5 double bond.
Additionally, DHT cannot undergo further reduction, nor is it a substrate for
aromatase; thus, it is not converted to estrogenic metabolites. DHT has been
shown to bind avidly to receptors in tissues, such as skin, scalp, and prostate,
and to exert 3-4 times the androgenic effect of testosterone. Thus, the primary
hormone mediating the androgenic effects of testosterone is actually the 5-alpha
reduced DHT.
Other mechanisms of direct and indirect anabolic effects include anti-
glucocorticoid activity mediated by displacement of glucocorticoids from their
receptor, increases in the creatine phosphokinase activity in skeletal muscle, and
increases in circulating insulinlike growth factor (IGF)–1, as well as up-
regulation of IGF-1 receptors.
These mechanisms may play a much larger role in the anabolic/anticatabolic
actions of anabolic-androgenic steroids (AASs)
than once thought.
At physiologic testosterone levels, nearly all androgen receptors are engaged.
Therefore, supraphysiologic doses of testosterone or AASs would have no
increased anabolic effect in healthy athletes unless other mechanisms of action
existed.
FORMATION OF TESTOSTERONE
DAILY PRODUCTION OF
TESTOSTERONE

THE TOTAL DAILY THE TOTAL DAILY

PRODUCTION OF PRODUCTION OF

TESTOSTERONE IN A MALE TESTOSTERONE IN A

IS ABOUT 7 MGS PER FEMALE IS ABOUT 2-3

DAY. MGS PER DAY.


MODE OF ACTION OF
TESTOSTERONE
MODE OF ACTION OF
TESTOSTERONE

The free testosterone in the serum is the only

active part of the hormone.

This amount represents about 2% of the

total hormone present in the circulation and

its half-life, that is, the time taken to destroy

half of the substance, is 10 minutes.


TESTOSTERONE
TOTAL AND FREE

Testosterone in the body is bound to protein called globulin

(SHBG – sex hormone binding globulin)

The free testosterone is available to diffuse into

your cells and affect the muscles.


Most of these uses are center on anabolic nature of these drugs, particularly in cachexia
produced in conditions like :-
1. HIV
2. HEPATIC FAILURE
3. RENAL FAILURE
4. COPD
5. SOME TYPES OF CANCER
6. BURNS
7. POST-OPERATIVE RECOVERY
IT PREVENTS THE LOSS OF LEAN BODY MASS IN THE ABOVE DISEASES.
COMMONLY USED AAS ARE:
OXANDROLONE, NANDROLONE AND OXYMETHOLONE
MECHANISM OF ACTION (PART:A)
STEROID RECEPTORS
mechanism of action of steroids

Stimulation of receptor molecules in muscle cells which activate specific genes to produce proteins
Effectiveness of anabolic steroids is dependent upon unbound receptor sites in muscle
Intense strength training increases number of unbound receptor sites
Research studies demonstrated improved performance in experienced weight lifters
MECHANISM OF ACTION (PART:B)

LIPID SOLUBLE – can diff use directly into a cell


(unlike peptide hormones like INSULINE AND IGF-1, which needs surface receptors to enter into
a cell)

1. STEROIDS ENTER INTO BLOOD STREAM


2. DIFFUSE INTO A CELL
3. BIND TO A RECEPTOR
4. INFLUENCE GENE TRANSCRIPTION
5. INFLUENCE CELL TO PRODUCE PROTEIN

ROUTE OF ADMINISTRATION - ORAL V/S INJECTABLE


What are anabolic steroids?
• Anabolic steroids are synthetic
variations of the male sex hormone
testosterone.

• The proper term for these compounds


is anabolic-androgenic steroids.

• "Anabolic" refers to muscle building,


and "androgenic" refers to increased
male sex characteristics.
COMMON NAMES FOR
ANABOLIC STEROIDS
Some common names for anabolics

• Gear

• Juice

• Roids

• Stackers
Steroids are a general class of agents that all have the steroid ring in common.
The steroid ring is comprised of three 6-carbon rings and one 5-carbon ring
joined, of which cholesterol is the most basic form and, indeed, the
precursor.

Testosterone is the principle hormone in humans that produces male


secondary sex characteristics (androgenic) and is an important hormone in
maintaining adequate nitrogen balance, thus aiding in tissue healing and the
maintenance of muscle mass (anabolic).
Testosterone has a dual action and can be described in terms of its
androgenic and anabolic capacities.
AASs are drugs derived from the modification of the testosterone
molecule in order to augment or limit certain characteristics of
testosterone. In general, testosterone has been altered to produce
drugs that are more or less anabolic, are more or less
androgenic, have differing affinity for the testosterone receptor, have
different metabolic breakdown pathways, or are efficacious for oral
use; they can also have any combination of these changes.
since 1950s, thousands different compounds have been synthesized in the hope of producing
compounds that have an anabolic or androgenic effect superior to that of testosterone.

Biochemists quickly noted that additions or subtractions to the testosterone molecule at


specific locations would have a somewhat predictable effect on the inherent qualities of said
compound.
Specifically, qualities including (but not limited to) anabolic/androgenic ratio, metabolism,
receptor affinity, and oral efficacy were noted.

In general, the goal of altering an AAS is to increase its anabolic characteristics and to
decrease its androgenic features, thus multiplying the compound's desirable, anabolic,
nitrogen-sparing effects and minimizing its generally undesirable, androgenic, virilizing
effects.

To date, however, complete dissociation of the anabolic effects of an AAS from its
androgenic characteristics has not been possible.
Clinically, AASs have been used to treat a host of conditions,
including the following:
• Many forms of anemia
• Acute and chronic wounds
• Protein-calorie malnutrition with associated weight loss
• Severe burns
• Short stature
• Osteoporosis
• Primary or secondary hypogonadism
• Prolonged catabolic state secondary to long-term use of corticosteroids
• Human immunodeficiency virus ( HIV) wasting syndrome
Structure of Testosterone & AAS

The defining characteristic,


structurally, of all steroids is
their four-ring structure.

This is called the Steran


Nucleus, and for our
purposes there are four rings
(A, B, C, and D),
and
19 positions on the structure
How Testosterone is converted to synthetic anabolic steroid
 First, A-ring metabolism…
 In the A-ring we see 5alpha and 5beta reduction taking place:
 5alpha Reduction (5a-Reduction) is what turns testosterone into
DHT.
 5beta-reduction is very similar, though not of prime concern to
us here.
 After this reduction, typically the 3-keto group is transformed.
 Stability and instability of the 3-keto group is important to
androgen binding, and the more stable the 3-keto group is, the
more avidly a compound can bind to the Androgen Receptor
and/or increase anabolic/androgenic activity.
 Certain modifications to steroids can enhance the stability of the
3-keto group, such as 2- methylation gives Masteron or adding a
2-hydroxymethelyne gives Anadrol.
How Testosterone is converted to synthetic anabolic steroid
 On the other hand, Ethylestrenol lacks a 3-keto group totally,
and is probably the weakest steroid available.

 Let’s take a look at the removal of the 3-keto group:


 Of course, the above example focused on testosterone, and if you
add a double bond between the one and two carbon atoms of
testosterone, you’ve made Boldenone(Equipoise).
 Add a 17-alpha-methyl group to that Boldenone we just spoke of,
and you have Methandrostenolone (D-bol), which is broken
down similarly, although it is orally active in the body due to the
17a-methly group:
How Testosterone is converted to synthetic anabolic steroid
 Now, let’s finally look at D-Ring metabolism…
 The D-ring is metabolized into testosterone’s main metabolites.
 This occurs by oxidation of 17b-hydroxy groups into 17keto
steroids.
 All of that was the first phase of anabolic steroid metabolism,
which determines the primary effects they will have in the body.

 Phase II metabolism has more to do with metabolites, their


degradation, and the eventual elimination of them and the steroid
from the body.
How Testosterone is converted to synthetic anabolic steroid

 Synthetic anabolic steroids are based on the principal male


hormone testosterone, modified in one of three ways:

a. Alkylation of the 17-carbon (makes them survive oral ingestion)


b. Esterification of the 17-OH group (alters active life and half life)
c. Modification of the steroid nucleus (changes their properties)
How Testosterone is converted to synthetic anabolic steroid
 Simple modifications to the four-ring steran nucleus of testosterone
can produce major changes in the hormone. From those simple
changes to testosterone, scientists have identified the other two major
families all anabolic/androgenic steroids are derived from:
 19-nor-Testosterone (sometimes called 19-nor’s) - is simply
testosterone that lacks a carbon atom in the 19th
 dihydroTestosterone (called DHT) - is Testosterone that has had 2
hydrogen atoms.
 In general, 19-nor derived steroids exhibit a high anabolic effect and a
low androgenic effect with not much aromatization, while DHT-
derived steroids usually have a very nice balance of androgenic and
anabolic effects and not much aromatization.
 Adding an ester extends their long life, does not change its
anabolic:androgenic properties.
 Adding a methyl group survives oral administration but it changes
anabolic:androgenic properties
TESTOSTERONE DERIVATIVES

The major classes of testosterone derivatives include the following


 Testosterone derivatives: direct derivatives of testosterone not falling into the
groups below
 4,5α-Reduced/dihydrogenated testosterone derivatives:
dihyrotestosterone(DHT) derivatives
 19-Demethylated testosterone derivatives:
19 nortestosterone(nandrolone) derivatives
 17α-Alkylated testosterone derivatives:
Methyltestosterone and ethyltestosterone derivatives
 17α-Ethynylated/vinylated testosterone derivatives:
ethynyltestosterone(ethisterone) and vinyltestosterone derivatives
 The last group consists of progestins with mostly only very weak
androgenic/anabolic activity.
TESTOSTERONE DERIVATIVES

TESTOSTERONE DERIVATIVE:
1. Testosterone
2. 4 – hydroxytestosterone
3. Boldenone
4. Clostebol

Pro-hormone like:
1. Dehydroepiandrosterone (DHEA)
2. Exemestane

Prodrugs:
1. Cloxotestosterone
2. QuinboloneTESTOSTERONE- PROPIONATE- PHENYLPROPIONATE –
ISOCAPROATE- DECANOATEne
DIHYDRO-TESTOSTERONE(DHT) DERIVATIVES

DI-HYDRO-TESTOSTERONE DERIVATIVES(DHT):
1. Dihydrostestosterone (DHT; androstanolone, stanolone)
2. Drostanolone
3. Epitiostanol
4. Mesterolone
5. Metenolone (methenolone, methylandrostenolone)
6. Stenbolone

Prodrugs: Ether
1. Mepitiostane

Azine dimers:
1. Bolazine
19 NOR-TESTOSTERONE(nandrolone) DERIVATIVES

19-NOR-TESTOSTERONE (nandrolone) DERIVATIVES


1. Nandrolone (nortestosterone)
2. Norclostebol
3. Oxabolone
4. Trenbolone

Prohormone like:
1. Bolandiol (nor-4-androstendiol)

Prodrugs: Esters
1. Bolmantalate (nandrolone adamantoate
17 a – ALKYLATED TESTOSTERONE DERIVATIVES

17 a – ALKYLATED TESTOSTERONE DERIVATIVES


1. Bolasterone
2. Calusterone
3. Chlorodehyromethyltestosterone
4. Fluoxymesterone
5. Formebolone
6. Metandienonen (methandrostenolone)
7. Methyltestosterone
8. Oxymesterone
9. Tiomesterone (thiomesterone)

Prohormone like:
1. Methyltestosterone 3 – hexyl ether
2. Penmesterol (penmestrol)
17 a – ALKYLATED DIHYDROTESTOSTERONE DERIVATIVES

17 a – ALKYLATED DIHYROTESTOTERONE DERIVATIVES


1. Androisoxazole
2. Furazabol
3. Mestanolone (methyl – DHT)
4. Oxadrolone
5. Oxymetholone
6. Stanozolol

Prodrugs: Azine dimers


1. Mebolazine (dimethazine, di-methasterone)
17 a – ALKYLATED 19-NOROTESTOSTERONE DERIVATIVES

17 a – ALKYLATED 19 – NORTESTOSTERONE DERIVATIVES


1. Ehthylestrenol (ethylnandrol)
2. Mibolerone
3. Normethandrone (methylestrenolone, normethisterone)

Prodrugs:
1. Propentandiol
17 a – VINYLATED 19-NOROTESTOSTERONE DERIVATIVES

17a -VINYLATED 19-NORTESTOSTERONE DERIVATIVES –WEAK


AAS
Norvinisterone (vinylnortestosterone)
Commentary:
The17α-ethenylated(vinylated)testosterone derivative Norvinisterone
(vinylnortestosterone) is much more potent as an AAS than the 17α-
ethynylatedtestosterone derivatives and is intermediate in potency
between the 17α-ethynylated progestins and conventional AAS, with
approximately one-third and one-fifth of the respective androgenic and
anabolic activity of nandrolone in animal bioassays.
Vinyltestosterone has been described as a weak AAS, though stronger
than its 17α-ethynylated analogue ethisterone.
17 a – ETHYNLATED TESTOSTERONE DERIVATIVES

17a – ETHYNYLATED TESTOSTERONE DERIVATIVES – weak AAS /


used as contraceptives
1. Ethisterone (ethinyltestosterone)
2. Danazol (2,3 isoxazolethisterone)
17 a – ETHYNLATED 19-NOROTESTOSTERONE DERIVATIVES

17a – ETHYNYLATED 19-NORTESTOSTERONE DERIVATIVES - weak AAS / used as


contraceptives
1. Norethistrone (norethindrone)
2. Gestrinone (ethylnorgestrienone)
3. Levonorgestrel
4. Lynestrenol
5. Norgestrel (18-methylnorethisterone)
6. Norgestrienone
7. Tibolone (7a-methylnoretynodrel)

Esters:
1. Etynodiol diacetate
2. Norethisterone acetate
3. Norethisterone enantate

Ethers and esters:


1. Quingestanol acetate
USAGE
They have two main effects on the human
body
AN ANABOLIC, OR MUSCLE BUILDING, EFFECT AN ANDROGENIC, OR MASCULINISING, EFFECT.

• Health care providers can prescribe steroids to treat hormonal issues, such as delayed puberty.

• Steroids can also treat diseases that cause muscle loss, such as cancer and AIDS.

• Some athletes and bodybuilders abuse these drugs to boost performance or improve their physical

appearance.
HOW
STEROID
WORKS
STEROIDS WORK, IN PART,
BECAUSE YOU EXPECT THEM TO
WORK
PSYCHOLOGICAL EFFECTS – mechanism of action of steroids

Creation of “psychosomatic state” characterized by


• Sensation of well being
• Euphoria
• Increased aggressiveness
• Tolerance to stress
• Allowing athlete to train harder

Other factors

• Learnt motor skill to exert maximal force during strength training


• Diet high in protein and calories
STEROIDS MAKES YOU BIGGER AND STRONGER
HOW ARE THEY ADVANTAGEOUS IN SPORTS?
Where absolute strength and size are paramount, they offer huge
• advantage
• Powerlifters
• Weightlifters
• Strongmen in the very top weight divison
• Bodybuilding
• Physique sports
FINALLY HERE ARE SOME TAKEAWAYS
• Steroids, physiologically, work. This much is not debateable.

• On top of how well they work physiologically, a major factor is how well they
work psychologically – if you do something expecting to get a ton stronger, there’s a
good chance you’ll get a ton stronger. This applies to much more than steroids.

• Steroids do provide a substantial advantage for sports that aren’t governed by weight
classes. However, taking too high of a dose right off the bat may actually decrease
performance (increased strength and mass, but decreased relative strength), especially
in sports with weight classes. If you decide to use steroids, you’ll probably get the best
bang for your buck, strength-wise, with very conservative doses initially.

CONTINUTED……
FINALLY HERE ARE SOME TAKEAWAYS

• If you take steroids and then come off of them, you’ll probably lose some of
the size and strength you gained, but you’ll always be at an advantage
relative to a lifetime drug-free athlete.
Anabolic steroids are beneficial in building up the body but, when the steroid course is finished,

the reverse action occurs and there is an increase in catabolism as a result of the corticosteroids

being taken up by the receptors again. This may be one reason for the weight loss that

occurs in some users at the end of the course.


HOW LONG STEROID USE BENEFITS YOU
The short answer – basically forever
METABOLISM OF

STEROID
STEP 1 – Steroids first metabolised in the nucleus of the cell

STEP 2 – They are then taken from the cell and degraded in
the liver

STEP 3 – Excreted in the bile or the urine

The actual excretion products vary from one androgen to another


and it is these products that are detected In sports drug testing
HOW STEROIDS ARE USED ?

•Understanding of the potential benefits and side


effects of using them.

•User should not be unrealistic in expectations

•Large and permanent gains cannot be made in


one course.
FACTORS THAT DETERMINE
THE RESPONSE TO STEROIDS

• Genetic make-up

• Training

• Illness

• stress

• Diet regulation
SIDE EFFECTS OF ANABOLIC
STEROIDS

• Anabolic steroids are also drugs and can cause side


effects.

Causes of side effects may be


A. Individual sensitivity to the drug
B. Using too much of the drug

• It must be remembered that what one person can use


safely, may be dangerous to another.

• As a rule of thumb the more steroids used the greater


the risk of side effects and the more serious they are
likely to be.
SIDE EFFECTS OF ANABOLIC
STEROIDS

• There are also instances of people reacting adversely to low


doses of steroids.

• There may also be evidence of taking other drugs, which can


exaggerate the steroid effects.

• Potential effects can be reduced or avoided by being aware of


the problems.

• Many but not all of the side effects are of a temporary nature
and will resolve within some weeks of ceasing the drugs.

• Knowledge of the side effects will allow you to recognise early


signs and thus reduce the overall risks
SIDE EFFECTS ON DIFFERENT SYSTEM

• Skin • Liver Changes


• Breasts • Sexual Disturbance
• Heart • Bleeding
• Fluid Retention • Hair Loss
• Aggression • Insomnia
i. Physical assault
• Tendon Damage
ii. Indirect hostility
• Young People – stunted growth
iii. Irritability
• Prostate Gland
iv. Negativism
v. Resentment
• Infections

vi. Suspicion • Women and Side Effects


vii. Verbal hostility
Most of the adverse effects of anabolic-androgenic steroid (AAS) use are dose
dependent and are reversible with cessation of the offending agent or agents.

Vital signs, including heart rate and blood pressure, and basic chemistries, such
as sodium, potassium, hemoglobin, hematocrit, BUN (blood urea nitrogen),
creatinine, hepatic, and lipid profiles, must be monitored carefully.

Monitoring these parameters will help the clinician to determine drug choice,
treatment dose, and duration, and will help to alert the prescriber to potentially
serious adverse effects that necessitate the discontinuation of therapy.
The most common deleterious effects of AAS use on the cardiovascular system
include increased heart rate, increased blood pressure, and changes in lipid
metabolism, including lowered high-density lipoprotein (HDL) and increased
low-density lipoprotein (LDL).
The increase in heart rate is thought to be more profound with the androgens,
especially those resistant to aromatase, and is believed to be due to the inhibition
of monoamine oxidase (MAO).
This effect, when combined with the increased renal recovery of ions, such as
sodium, causing subsequent fluid retention, can lead to dramatic increases in
blood pressure.
Combine this with a tendency to lower HDL and raise LDL, and the stage is set
for untoward atherogenic and cardiac effects.
Anabolic steroid users can have a lower left ventricle ejection fraction.
Ananbolic steroid abuse has been associated with ventriculararrhythmias.
The alanine aminotransferase/aspartate aminotransferase (ALT/AST) can be
seen to rise, usually in a dose-dependent fashion. Levels approaching 2-3 times
baseline are often set as upper limits of reference ranges when administering
oral AASs, but the risk-to benefit ratio must be constantly evaluated.
AAS use also results in suppression of clotting factors II, V, VII, and X, as
well as an increase in prothrombin time.
Another life-threatening, albeit rare, adverse effect that is seen in the liver and
sometimes in The changes made to C-17 to inhibit hepatic degradation make
nearly all oral preparations hepatotoxic.
peliosis hepatitis, which is characterized by the appearance of blood-filled,
cystic structures. These cysts, which may rupture and bleed profusely, have been
found in patients with near-normal liver function test (LFT) values, as well as in
individuals who are in liver failure. Fortunately, drug cessation usually results in
complete recovery.
Primary liver tumors have been reported, most of which are benign, androgen-
dependent growths that regress with the discontinuation of AAS therapy.
Several case reports exist of young, healthy athletes who have died from primary
malignant liver carcinoma, with the only identifiable risk factor being oral AAS
use.
Anabolic steroid abuse has been considered a risk factor for non-alcoholic fatty
liver disease
•The endocrine system has a remarkable array of checks and balances that ensure the
human body is at or near homeostasis at any point in time. Interruption of one feedback
system has been shown to produce changes in other hormone feedback systems via direct
receptor changes, as well as through competition for common enzymes and metabolic
pathways.
•Studies have shown that AASs bind to glucocorticoid, progesterone, and estrogen
receptors and exert multiple effects.
•By suppressing FSH, spermatogenic function should be reduced.
•AASs have also been shown to alter fasting blood sugar levels and decrease glucose
tolerance, presumably due to either a hepatic effect or changes in the insulin receptor.
•Thyroxine-binding globulin (TBG) may also be lowered by AASs and result in lowered
total T4 levels, with free T4 levels remaining normal. An up-regulation of sex-hormone
binding globulin, with a concomitant decrease in TBG, is thought to cause the changes in
total T4 levels.
•The aromatization of testosterone/AASs to estradiol and related compounds can render
many adverse estrogenic effects. The most apparent and common adverse effect is the
growth of tender, estrogen-sensitive tissue under the male nipple. This unsightly growth is
termed gynecomastia and can be treated medically or surgically.
The male prostate is very sensitive to androgens, especially those that are reduced in prostatic
tissue to dihydrotestosterone (DHT) or DHT analogs.
In response to this stimulation, the prostate grows in size, potentially causing or exacerbating
benign prostatic hyperplasia (BPH). Worsening BPH may indeed cause severe bladder and
secondary renal damage.

In addition, the use of AASs in patients with underlying carcinoma of the prostate is
absolutely contraindicated due to the potential for hormone-sensitive tumor growth.

Studies have shown no urinary symptoms, urine flow rate, or urine postvoid residual.
Direct clotting factors may be reduced with an increase in prothrombin time. In patients on
concomitant anticoagulant therapy, this increase could cause bleeding.

AASs cause increases in hemoglobin and hematocrit and are used in many cases of
anemia, although the clinician must be aware of the potential for polycythemia.
Skin, especially the face and scalp, has a high degree of androgen receptors and 5AR.
DHT is known to cause increases in sebum production, leading to clinical acne. Also, male
pattern baldness is related to scalp DHT production and binding, along with genetic factors
influencing hair growth.
Male pattern baldness is greatly exacerbated by most AASs in susceptible individuals.
• Self- prescribing habits
• Stacking
• Multiple drugs in a cycle of 12-16 weeks
• Dose 2-8 times higher that the therapeutic range
• Multiple drug use increases side effects and risk to the user
• Decreased or no medical surveillance
• Mood elevator eg. Mesterolone versus amitryphtilline
• Behavior problems
• Addictive
• Withdrawal symptoms includes depression, fatigue, paranoia and
sucidal thoughts
A research in 1983 showed that the pyschoactive effects, withdrawal
symptoms and underlying biological mechanism of AASs appear to be
similar to cocaine, alcohol or opiod abuse.
MEDICAL EXAMINATION BEFORE STARTING
ANABOLIC STEROIDS
RESTING ECG
1.
Physical Examination:
2. TREADMILL STRESS TEST
3. 2D ECHO – OPTIONAL / FOLLOW –UP 1. Skin
4. ANGIO CT – OPTIONAL / FOLLOW-UP
5. BLOOD SUGAR TESTING
2. Temperature
6. HB1 AC 3. Pulse
7. LIPID PROFILES
8. CBC 4. Blood pressure
9. ESR
10. URINE ROUTINE & MICROSCOPIC
5. Pre-existing medical
11. LIVER PROFILE condition
12. RENAL PROFILE
13. SEMEN ANALYSIS
6. Any signs and symptoms of
14. THYROID TESTS steroid side effects
15. USG ABDOMEN AND PELVIS
16. DEXA SCAN
TYPES OF STEROIDS
 Doctor Prescribed Steroid
 Inject able Steroids  Fat Loss Steroids
 Oral Steroids
 Steroid Cream  Horse Steroids
 Steroid Pills  Illegal Steroids
 Steroid Tablets  Mexican Steroids
 Best Steroids  Muscle Building Steroids
 British Dragon Steroids  Natural Steroids
 Bulking Steroids
 Cheap Steroids
 Oral Anabolic Steroids
 Cutting Steroids  Real Steroids
 Designer Steroids  Safe Steroids
There are 32 common types of steroids which represent the anabolic
androgenic steroids that can be used by anyone who supplements with
such hormones for any reason
The form of administration and ester(s) does not change the
hormones specific nature
Example: Testosterone
•These 32 types of steroids can be used in numerous purpose.
•Unlikely anyone will ever use all of them
•Last trait associated with AAS supplementation can be obtained with
just a few.
•Most common steroid will carry a primary purpose; traits that carry
primary purpose.
•They will also carry secondary characteristic that can serve another
purpose too.
•Versatile steroids can meet almost any purpose of steroid
supplementation
•Mode of administration can affect compounds versatility
ORAL STEROIDS
 There are many oral steroids & with each one of them there are
various traits, benefits and purposes.
 In general for most male anabolic steroid users they should not
be the foundation in-which their use is built upon.
 Most cycles should be built around exogenous testosterone use.
As a general rule of thumb testosterone should be your base.
 Most common concerns is liver damage.
 In general oral steroids should only be used for 6 to 8 weeks.
 Oral steroids generally has much shorter half-life than the many
injectable steroids; for this reason daily use is generally needed
to receive the maximum benefit.
 “Small Doses” spread out over the day is one of the many keys to
successful and responsible anabolic steroid use, even more so
when speaking of oral steroids.
ORAL STEROIDS
COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE
OXYMETHOLONE ANADROL Anaemia, muscle wasting Promote mass
disease Fullness in cutting phase

OXANDROLONE ANAVAR Promote weight gain, Conditioning in cutting


osteoporosis cycle, moderate strength
increases, enhanced
recovery, enhance
metabolic rate, used by
both men and women
TESTOSTERONE ANDRIOL Used to treat low Highly inefficient for
UNDECONOATE testosterone or performance –
andropause treatment absorption issues and
plan strong hepatotoxicity
METHANDROSTENOL DIANABOL Not used for therapeutic Promote mass, strength
ONE use & muscular endurance
COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE
METHENOLONE PRIMABOLAN Not used Promote conditioning &
ENANTHATE recovery – rarely used
due to lack of C17 – aa
nature that accompanies
most oral state

MESTEROLONE PROVIRON Not used Anti-estrogen properties


– can promote free
testosterone

FLUOXYMESTERON HALOTESTIN Rarely used for delayed Promote strength,


puberty increase strength more
rapidly than any steroid

STANOZOLOl WINSTROL Used for regenerative Used for cutting – great


anaemia, angioedema, for conditioning –
severe strength loss, strength enhancement in
obesity athletes – improves
muscular endurance –
strong metabolic
enhancing properties
TRANSDERMAL STEROIDS

COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE


TESTOSTERONE ANDRODERM Low testosterone state Not used
or andropause
treatment plan
TESTOSTERONE ANDROGEL Low testosterone state Not used
or andropause
treatment plan
SUBCUTANEOUS IMPLANT

COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE


TESTOSTERONE TESTOPEL Low testosterone state Not used
or andropause
treatment plan, libido
deficiencies in females
INJECTABLE STEROIDS
COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE
NANDROLONE - DECA-DURABOLIN Renal insufficiency & Promote mass or tissue
DECANOATE anaemia, severe muscle growth, tremendous
wasting disease recovery & rejuvenation,
promotes joint relief
NANDROLONE- DYNABOLAN Not used Rarely used to promote
UNDECANOATE off season mass – stong
healing & rejuvenating
properities – excellent
for recovery
NANDROLONE DYNABOL Not used Rarely used to promote
CYPIONATE off season mass – stong
healing & rejuvenating
properities – excellent
for recovery
BOLDENONE EQUIPOISE Not used for therapeutic Promote strength,
UNDECYCLENATE use recovery, enhance
conditioning, great for
recovery & endurance,
promote mass with other
agents
COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE
TRENBOLONE FINA Not used Truly versatile – can
ACETATE promote mass, strength
and tremendouse cutting
or conditioning effects –
promotes recovery and
rejuvenation at a high
rate – extreme metabolic
enhances – can be used
for all purposes
DROSTANOLONE MASTERON Not used Used almost solely for
ENANTHATE conditioning purpose
such as hardness, dryness
and overall definition –
strong anti-aromatase
like effect
DROSTANOLONE MASTERON Not used Used almost solely for
PROPIONATE conditioning purpose
such as hardness, dryness
and overall definition –
strong anti-aromatase
like effect
COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE
TESTOSTERONE NEBIDO Used to treat low Not used
UNDECONOATE testosterone or as part of
an andropause treatment
plan

NANDROLONE NPP OR DURABOLIN Commonly used for Commonly used to


PHENYLPROPIONATE renal insufficiency and promote mass or tissue
anaemia – sometime for growth – tremendous
severe muscle wasting revocery promotion and
disease rejuvenation – strongly
promotes joint relief.
TESTOSTERONE OMNADERM Not used Highly versatile – can
PROPIONATE – promote mass, strength,
PHENYLPROPIONATE conditioning – preserve
– ISOCAPROATE- tissue, promote recovery
CAPROATE and rejuvenation –
tremendous metabolic
enhancer
COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE
TRENBOLONE- PARABOLAN Not used Mass, Strength and
HEXAHYDROBENZYL tremendous cutting or
CARBONATE Conditioning effects –
promotes recovery and
rejuvenation at a high
rate
– extreme metabolic
enhancer – can be used
for
all purposes
METHENOLONE PRIMABOLAN DEPOT Not used Excellent for
ENANTHATE Conditioning,
preservation, recovery
and
rejuvenation – can
promote mass when
other
mass agents accompany
TESTOSTERONE- SUSTAN - 250 Used to treat low Highly versatile – can
PROPIONATE- testosterone or as part of promote mass, strength,
PHENYLPROPIONATE an andropause treatment conditioning – preserve
-ISOCAPROATE- plan tissue, promote recovery
DECANOATE and rejuvenation –
COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE
TESTOSTERONE NA Used to treat low Highly versatile – can
CYPIONATE testosterone or as part of promote Mass,
an andropause treatment Strength,
plan Conditioning –
Preserve
tissue, promote
recovery
and rejuvenation –
tremendous metabolic
enhancer
TESTOSTERONE NA Used to treat low Highly versatile – can
ENANTHATE testosterone or as part of promote Mass,
an andropause treatment Strength,
plan Conditioning –
Preserve
tissue, promote
recovery
and rejuvenation –
tremendous metabolic
enhancer

TESTOSTERONE NA Used to treat low Highly versatile – can


COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE
TESTOSTERONE NA Used to treat low Highly versatile – can
SUSPENSION testosterone or as part of promote Mass,
an andropause treatment Strength,
plan Conditioning –
Preserve
tissue, promote
recovery
and rejuvenation –
tremendous metabolic
enhancer
TRENBOLONE NA Not used Mass, strength and
ENANTHATE tremendous cutting or
conditioning effects –
promotes revocery and
rejuvenation at a high
rate – extreme metabolic
enhancer – can be used
for all purposes
STANOZOLOL WINSTROL DEPOT Used to treat Non- Almost always used for
Regenerative Anemia, Cutting – great for
Angioedema and Severe conditioning – used in
strength loss – athletic for strength
COMPOUND TRADE NAME THERAPEUTIC USE PERFORMANCE
TURINABOL Not used Used to promote
Strength
– can promote
conditioning
to a degree – solid
recovery steroid
The best Bulking steroids

 Choose bulking steroids that will add quality mass in the most efficient and effective ways
possible.
 Safety should be major concern because each anabolic steroid can carry with it its own various
side-effects as well as level of probability in side-effects occurring and you are encouraged to
seek out the specifics of each one.
 For a good bulking cycle most all men will find testosterone to be king.
 It is generally very well-tolerated by all healthy adult men it is also by far the most efficient
anabolic steroid of all time. It does not matter which form of testosterone you use.
 For a good bulking cycle you are encouraged to always make testosterone your base and for
many this will be the only steroid needed but of course some will want more. Best bulking
steroids of all time include:
1. Testosterone
2. Deca-Durabolin
3. Dianabol
4. Anadrol
5. Trenbolone
Cutting Steroids vs. Bulking Steroids

 Almost all anabolic androgenic steroids can be used for either


purpose and all can have a place in most any type of cycle.
 The prime example would be of testosterone, the foundation of
most all cycles and the best of both worlds.
 Testosterone can be used to aid in increasing both mass and
strength; it can be used to aid in preserving mass and strength
while leaning out and it can serve both purposes in a primary way.
 Trenbolone is perhaps the primary steroid besides testosterone
that fills this category.
 Most all so-called cutting steroids can be used for bulking and vice
versa.
The best Cutting steroids

 While every one of these anabolic androgenic steroids serves a multitude of purposes, each
one of the following serves the purpose of cutting to a larger degree than bulking.
1.Winstrol (Stanozolol)
2.Anavar (Oxandrolone)
3.Halotestin (Fluoxymesterone)
4.Masteron (Drostanolone Propionate)
5.Primobolan (Methenolone Acetate)
6.Primobolan Depot (Methenolone Enanthate)
7.Turinabol (4-Chlorodehydromethyltestosterone)
The best Fat-loss steroids

 Trenbolone as a powerful muscle building, strength increasing and hardening agent has
also been shown to possess fat reduction qualities.
 Trenbolone have been shown to actually reduce stored body fat; while increasing lean tissue,
which leads to more pleasing total of fat versus lean tissue, coupled with actual fat reducing
qualities, this makes Tren more or less the king of this category when we consider the rates in-
which it handles both processes.
 Beyond Tren, other well-deserving fat loss steroids would include:
1. Winstrol
2. Primobolan
3. Anavar
4. Masteron
5. Equipoise
Common mistaken Fat-loss steroids

 The performance enhancing world is full of many items that are in-fact not anabolic androgenic
steroids.
 Human growth Hormone: HGH belongs to a class of hormones known as peptide
hormones; these are not steroids.
Beyond HGH many often labeled fat loss steroids that are not steroids at all include:
 Clenbuterol
 Cytomel (t-3)
 Albuterol
 Ephedrine
Muscle building steroids

 The most Efficient muscle building steroid


 First choice – Testosterone
 Followed by – Deca-Durabolin (Nandrolone decanoate)

 The most effective muscle building steroid


 Dianabol: a mere 4-6 weeks of Dianabol use can present gains of up to 20lbs and much of
it, not all but a good bit will be lean tissue.

 The most powerful muscle building steroid


 Trenbolone: Because of Testosterone’s efficiency it is a close second, a very close second
but Trenbolone is 400 times more powerful than testosterone.
All purpose steroids

1. Testosterone (Test-E, Cyp, Sust, Prop, Susp, etc)


2. Tren (Trenbolone-Acetate)
3. Equipoise (Boldenone Undecylenate)
4. NPP (Nandrolone Phenylpropionate
Primary Bulking steroids

1.Deca-Durabolin (Nandrolone Decanoate)


2.Dianabol/Dbol (Methandrostenolone)
3.Anadrol (Oxymetholone)
The Bottom Line

 All the steroids in the Primary Cutting Steroids category and all
the steroids in the Primary Bulking Steroids category can be
effectively used for the opposite purpose and in many cases very
effectively and efficiently.
 The key is understanding how each anabolic androgenic steroid
you wish to use functions and reacts.
 Understand proper nutritional intake that meets your end goals
and by understanding nutrition and steroid function you will
best understand how to maximize the two and reach optimal
results.
 In truth you cannot have an understanding of one and not the
other and expect to reach your best; they work together hand-in-
hand.
WHEN AND HOW TO USE
STEROIDS

• A weight-training programme will lead to increased strength


and an increase in muscle. mass.
• Steroid use should not be considered until the athlete has
plateaued.
• The importance of diet cannot be overemphasised and must
contain sufficient carbohydrate food to support a training
programme. The muscle needs protein to grow but it cannot
work efficiently without the fuel and this is best provided by
carbohydrate foods. Carbohydrate also attracts water into the
muscle cell and this results in an increase in the bulk of the
muscle.
WHAT STEROIDS TO
USE
• All steroids produce the same result at the end of a course. They stimulate the cell nucleus to

produce the protein characteristic of the cell. For Example: In the case of muscle cells, that will

be muscle protein. This is the desired result of using the steroid.

• Effects using single dose and multiple dose

• Whether to use oral or injectable drugs – route of administration is not important factor

• Rate of uptake of different steroids by the steroid receptors

• For a second or later course of a drug – using the same anabolic steroid. The body does not

develop tolerance and results can be achieved with the same steroid, providing that the

training programme and diet are adequate.


CHOOSING THE RIGHT STEROID

One of three goals at a time people use AAS:


 bulking
 cutting or
 enhancing athletic performance.

 If you try to do two or more at a time, especially if you try to add mass while trying to cut,
a virtual impossibility at any significant level, you’re going to find it an extremely
frustrating process.

 if it’s bulking you’ll be able to add more lean mass with less fat accumulation,

 if you’re trying to cut you’ll be able to lose more body-fat with less muscle tissue loss that
often accompanies hard dieting.

 As bulking and cutting represent the two primary reasons most people supplement, but
you must ensure you are eating correctly to promote this end and exercising as per your
goals bulking or cutting

ANABOLIC STEROIDS CYCLES & STACKS
An anabolic steroid cycles refers to the time frame anabolic
steroids are being used. This time frame is often referred to as
“On-Cycle.”
When steroids are not being used, this is referred to as “Off-
Cycle.”
For the on-cycle phase, there are countless options and stacks.
“Stacks” refer to the combination of anabolic steroids as well as
non-steroidal items used during the on-cycle phase.
With hundreds of anabolic steroids, varying peptide hormones,
SERM’s, AI’s, thyroid hormones and more, there are truly
innumerable possible stacks
RULES OF CYCLES & STACKS
FIRST STEROID CYCLE
 The primary rule of every cycle is that it includes some form of
testosterone. The form of testosterone used is of no consequence. The only
thing that matters is that the body has enough of this essential hormone in
order to function properly.
Exception: The use of essential testosterone does not apply to female
anabolic steroid cycles.
 If you’ve never supplemented with anabolic steroids before, it’s
recommended that you keep things as simple as you can. You have no idea
how your body is going to react to supraphysiological doses of a hormone.
Further, you want to start with hormones your body is already familiar
with, such as testosterone.
 If you begin with numerous steroids in your cycle, if you have any
problems, it is going to be extremely difficult to pinpoint what’s causing the
problem.
 Equally important, you may have a hard time pinpointing which steroids
bring you the greatest results.
 Start simple and work your way up.
RULES OF CYCLES & STACKS
ADVANCE CYCLES & STACK
 Once you have a few cycles and stacks under your belt, &
have had positive experience, you can now consider moving
to more advanced cycles.
 For most men, there may be no need or desire to increase
the number of hormones being used or an increase in doses.
 A simple and moderately dosed testosterone cycle may be
all you ever need, and such a cycle will work for you every
single time. Your body isn’t going to magically adapt to
where such a plan will no longer work.
 Despite this, many men will inevitably want more if they’ve
enjoyed success with smaller steroid cycles.
 However, bigger stacks and cycles come with a word of
caution.
Risk to Reward

 All steroid cycles and stacks carry with them a strong risk to reward ratio, and
regardless of your experience this will hold true each and every time.
 The more you take the greater the reward, but the more you take the greater the
risk.
 As risks increase, so does the need for protective measures.
 But there will be a cutoff point; where safety is severely jeopardized and the risk
to reward ratio becomes severely inclined towards risk.
 Important factors to consider : steroid being used and genetic
 Example: Testosterone (any ester)
 Dose – 300 mg /week, maximum being 500 mg / week well tolerated
 Some men can go up to 750-1000 mg & can still remain healthy
 When we surpass 1g per week, estrogenic issues can often be problematic, and
many men will find controlling them extremely difficult
Duration of Use
 As steroid cycles refer to the time in which we are actually supplementing with
anabolic steroids, the obvious question are:
1. What is the acceptable time frame?
2. What is the minimum for positive gains?
3. What is the maximum amount of time in-regards to safety?
 The human body does not like change; even if such a change is in its best
interest it will fight it and do all it can to stay at its accustomed normal.
 We must allow enough time for this “normal” to change.
 We must create a new set normal if we are to hang onto any of the gains
made.
 If you are off-cycle for an extended period of time you are going to lose some
of the gains made; without the high influx of hormones present to support
the gains you made they will not last forever.
Duration of Use

 In order to create a new set normal


 Minimum period – 8 weeks
 Maximum – 12 weeks – more efficient
 For those looking for solid gains while remaining as safe as possible, 12-16 weeks
of actual supplementation followed by an equal amount of time off-cycle is the
best bet.
 This is an effective plan, but absolute safety cannot be guaranteed, it will be the
plan that carries the greatest potential for a safe experience.
 For the hardcore elite, the truly advanced steroid user, you will find they are
often on-cycle far more than they are off. This is the only way such individuals
can support the massive strength and size they’ve obtained.
 For Elite Body- Builders :
16-20 week cycles and only discontinue for 4-8 weeks.
In some cases, they may not fully discontinue at all.
In some cases, such men will simply drop to a low dose of testosterone for 4-8
weeks before beginning another 16-20 week blast.
How do we know when we’re ready to advance?

 Novice to Intermediate:
1. Completed a few novice cycles and done so successfully.
2. Not suffered from severe side effects
3. Have made decent gains but have reached a point where you want a little more.
 Intermediate to Advanced:
1. Intermediate cycles are as much as most will ever want, and in truth, most all will ever
need.
2. If you cannot make fantastic gains with such plans, you need to reexamine your diet and
training.
3. If you have completed several intermediate cycles successfully, have a desire to reach highest
levels of muscularity; an advanced cycle may be in store.
 Beyond Advanced:
The advanced steroid cycles listed below are incredibly powerful and carry with them a
significant level of risk. However, some will surpass advanced plans. This is not something we
can ever recommend, we cannot recommend such plans.
HOW TO COME OFF STEROIDS LONG EXTENDED
PERIOD?
It is called PCT (Post cycle Therapy)
SELECTIVE ESTROGEN RECEPTOR MODULATOR – any one
1. Tamoxifen citrate (Nolvadex)
2. Clomiphne Citrate (Clomid)
SERM stimulate the pituatary to release more LH and FSH which
in turn stimulate the testicles to produce more testosterone
HUMAN CHORIONIC GONADOTROPHIN (HCG)
HCG act to stimulate natural testosterone through an LH
mimicking effect; LH is not actually released, but your body
think it is.
HCG use is not always needed but it can be a perfect way to
prepare your body for the SERM therapy to come.
USE OF SERM:
If your steroid cycle is of a simple or moderate nature (upto 12
weeks), you will need SERM for 4 weeks.
Above this you need 5-6 weeks of SERM therapy and 10 days of
HCG therapy preceding it.
CLOMID – 150 – 100 – 50 MG / ED (reducing dose every 2
weeks)
NOLVADEX – 40 – 20 -20 MG / ED ( reducing dose every 2
weeks)
HCG – 500 – 1000 iu for 10 days (never be surpassed in dose and
duration)
WHEN TO START SERM & HCG?
LARGER ESTER & SERM ONLY – like caproate, cypionate,
enanthante, decanoate, heptanoate, hexanoate, isocaproate,
nonanoate, octanoate or undecyclenate
SERM therapy 14-18 days after your last injection
SMALL ESTER & SERM ONLY – acetate, formate,
phenylpropionate or propionate
SERM therapy should start 3 days after your last injection
If you have butyrate or valerate based steroid, you might wait a few
more days to start SERM therapy.
WHEN TO START SERM & HCG?
LARGER ESTER , SERM & HCG ONLY – like caproate,
cypionate, enanthante, decanoate, heptanoate, hexanoate,
isocaproate, nonanoate, octanoate or undecyclenate
HCG therapy – 10 days after your last injection x 10 days
SERM therapy immediately after HCG therapy
SMALL ESTER & SERM ONLY – acetate, formate,
phenylpropionate or propionate
HCG therapy – 2 days after your last injection x 10 days
SERM therapy should start immediately after HCG therapy.
If you have butyrate or valerate based steroid, you might wait a few
more days to start SERM therapy.
AROMATASE I NHIBITOR (AI’s) in PCT PLAN
1. ANASTROZOLE (ARIMIDEX)
2. LETROZOLE (FEMARA)
3. EXEMESTANE(AROMASIN)
Will stimulate LH & FSH in a similar fashion as a SERM But they
are used to reduce estrogen level dramatically to combat
estrogenic and progestin related anabolic steroid side-effect
when on cycle.
HOW TO COME OFF STEROIDS SHORT PERIODS AND BRIDGING ?
If you are going to be off cycle for a short period of time, less than
12 weeks, PCT plan above are not beneficial.
OPTION 1:
Best is stay off everything for a few weeks – you will lose lean
tissue but if you stay consistent with your training and diet it
won’t be much.
OPTION 2:
Low dose of testosterone 200 – 250 mg per week
OPTION 3:
Low dose of Nolvadex and Dianabol (10 mg /day of each for four
to five weeks)
ANABOLIC WORKOUT

• What role does the use of anabolic/androgenic steroids play-


Very simple: athletes who take steroids will make clearly
faster, better, and greater progress than their natural
colleagues. They will also obtain a much higher development
stage than would have ever been possible without taking
pharmaceutical compounds.
1. HIGH INTENSITY TRAINING
2. TRAINING WITH A RELATIVELY LOW REPS
3. TRAINING WITH A PROGRESSIVELY HIGHER WEIGHTS
4. SUFFICIENT REST PERIODS
5. PLATEAU AND PHASE TRAINING
ANABOLIC WORKOUT
• The intervals between the various sets should be 3-4 minutes.
• The exercises -as much as possible- are carried out with free weights and not on
machines.
• Every muscle is directly trained only once every eight days.
• Every set is carried out until muscle failure. Only in this case are the relatively
few sets and especially long rest periods justified.
• The muscle cell must be brought in a strongly catabolic condition since only
then the distinct anticatabolic effect of anabolic/androgenic steroids develops
fully.
• The required intensity of training, however, can only be achieved when you start
(after a short warmup) with the heaviest weight possible and then decrease the
weight in every following set because of the losing body strength so that the
desired repetitions can still be obtained
1. STRENGTH TRAINING IS INCREDIBLY TAXING ON THE
BODY'SCENTRAL NERVOUS SYSTEM
2. STRENGTH TRAINING RELEASES MORE GROWTH HORMONE &
TESTOSTERONE
3. STRENGTH TRAINING CREATES A PLATFORM TO ACHIEVE MORE
SETS AND REPS
4. STRENGTH TRAINING BENEFITS THE SMALLER MUSCLE
GROUPSAS WELL
5. STRENGTH TRAINING INVOLVES THE MAXIMAL AMOUNT OF
MUSCLE FIBERS
6. STRENGTH TRAINING DOES NOT EAT UP YOUR
PRECIOUSCALORIES
7. STRENGTH TRAINING LEADS TO PROGRESSIVE OVERLOAD
ANABOLIC DIET
• Three primary micronutrients - protein, carbs and fat and the ratio in which to consume
them.
• Some micronutrients – vitamin, minerals and others
• Protein is the building block – complete & good quality protein.
• Incomplete protein – grains, vegetables and fruits
• In men aged 59-69 years old, Strength training produced greater muscle mass gains with
a meat containing diet in comparison to a lacto-ovo-vegetarian diet. No clear benefits in
young athletes.
• Ideal protein – whey – high bioavailability, high content of gluamine, BCAA. Immediately
post workout.
• Casein – before workout and for extended amount of time and at night.
• Intense cardio increases protein need by 50-75% and strength training by 100%.
ANABOLIC DIET
• Protein requirements
• Ingest 1g/lb of body weight of quality protein (2.2/kg)
• Take atleast half of your protein from whey and at least half of that needs to be in a
post-workout meal
• All proteins should be complete protein
• CARBOHYDRATES – simple and complex
• Carbs intake immediately following exercise can easily enhance muscle glycogen re-
synthesis compared to several hours after workout.
• Carb + protein beverage – post workout better than taking alone.
• 50% of carbs to be taken post-workout, remaining 50% distributed in other meals
throughout the day.
• Total carbs – 1/3 rd of total calories
• Complex carbs all day, simple carbs post workout
ANABOLIC DIET
FATS
• Avoid saturated fats completely with steroids – cholesterol & insulin sensitivity
• Saturated fats like french fries, egg and cheese can be used carefully
• Unsaturated fats – linoleic oil, avocados and nuts
• Polyunsaturated fats like safflower oil – moderately healthy
• Fish oil – omega-3 fatty acids
• Total intake – 1/3rd of total calories
• Avoid hydrogenated fats
OTHER DRUGS
• Human Growth Hormone
• Insulin
• Insulin Growth Factor 1
• Clenbuterol
• Creatine
• Human Chorionic
Gonadotrophin (HCG)
• Tamoxifen
• Diuretics
• Testosterone Precursors
i. DHEA
ii. ANDROSTENEDIOL
INJECTING ANABOLIC
STEROIDS
• Injecting drugs can be a hazardous procedure with

serious risk of injury and disease.

• Anabolic steroid injectors need to follow some basic

rules and procedures to minimise the potential harm.

• Anabolic Steroids should only be injected into a

muscle.

• Anyone considering self-injection should first get

advice from a health professional.


Anabolic steroid injectors need to follow some basic
rules and procedures to minimise the potential harm

• Sterile Equipment

• The Correct Equipment

• Keep it Clean

• Drawing up from an ampoule or vial

• Where to inject

• other sites

• pre-injection

• the injection

• post-injection
COMPLICATIONS OF POOR
INJECTING TECHNIQUES

• Infection

• Muscle Damage

• Nerve, Tendon and Ligament Damage

• Haemorrhage
INDIVIDUAL DRUG-PROFILE
 ANADROL:
 Anadrol has been derived from Dihydrotestosterone
 By addition of a hydroxymethylene group to DHT, it becomes the only DHT
that is used to bulk rather than for cutting.
 If you want to increase the sizes of your muscles just before a competition,
this is the one to use.
 Because Anadrol is oral, it has been modified to be able to pass through the
stomach and the digestive system in one piece.
 It has to pass through the liver and get into the muscles without being
eliminated by the liver.
 Chemically speaking, it has been made into a 17-alpha alkylated steroid
meaning that the 17th carbon atom has been altered.
 One of the best steroid for bulking in short time.
 Also used in wasting disease like AIDS due to its strong muscle building
properties
INDIVIDUAL DRUG-PROFILE
 SIDE EFFECTS OF ANADROL– due to araomatization
leading to estrogen formation
1. water retention
2. Affects athletic performance
3. Increase in blood pressure – long standing use
4. Gynaecomastia – particularly in man
INDIVIDUAL DRUG-PROFILE
ANAVAR (OXANDR0LONE):
 It is mild but powerful
 Mild – because of its extemely high threshold of tolerance.
 Both men & women can tolerate this steroid fairly well.
 Single most female friendly anabolic steroid in the market.
 Used to gain weight following surgery or infection or any ailment that
resulted in weight loss.
 Useful in osteoporosis by promoting bone density
 Also useful in prolonged exposure to corticosteroids
 Combats hepatitis
 Useful in children to promote growth & development who lack proper
hormone production.
INDIVIDUAL DRUG-PROFILE
ANAVAR 101:
 It is a DHT derive AAS.
 It is altered form of DHT with an added oxyen atom replacing the carbon-2
in the A-ring.
 This structural change prevents metabolic breakdown and enhaces its
anabolic acitivity significantly.
 There is also a structural change to the hormone at 17th carbon position
throug addition of methyl group.
 This change help to survive oral ingestion.
 Hepatotoxic in nature but mild.
 High anabolic – anabolic rating is 3-6 times stronger than testosterone.
 Anabolic effect more useful in cutting and athletic enhancement cycles.
 Low androgenic (rating of 24) effects which makes it more tolerable
compared to other AAS.
INDIVIDUAL DRUG-PROFILE
ANAVAR 101:
Three primary traits
1. Enhance nitrogen balance – anabolic atmosphere and protects the individual
from catabolic state.
2. Ability to significantly reduce SHBG – increase free testosterone
3. Reduction of gluco-corticoids – prevent fat gains
 It burns body fat – because of its firm binding to androgen receptors and
reduce thyroid binding globulin and increase thyroxin-binding prealbumin.
Through this action T3 (triiodothyronine)is utilized to a higher degree.
 Increase blood count leading to higher oxygenation – promotes muscular
endurance.
 FOR MEN – not a good off season steroid for bulking.
 FOR WOMEN – best choice as off season steroid
 EXCELLENT CUTTING STEROID – preserve muscle mass during dieting
 CONDITIONING EFFECT – harder and more defined appearance.
 ATLETIC PERFORMANCE – BEST CHOICE
INDIVIDUAL DRUG-PROFILE
SIDE EFFFECTS:
 No aromatization – no estrogenic side effect
 Androgenic side effects – less likely than other AAS. Hair loss and acne
if sensitive.
 For Female – virilisation possible but less likely if doses are
monitored. Genetic will dictate the final outcome.
 Virlization symptoms in females – clitoral enlargement, body hair
growth or deepening of voice – use discontinued immediately.
 Increases LDL cholesterol and decrease HDL cholesterol.
 Low testorsterone levels if exogeneous testosterone is not included.
 Hepatotixicity – most mildest hepatotoix AAS. – limit total use to 8
weeks, avoid alcohol and other c17 aa steroids. Supplement with liver
detoxifier.
INDIVIDUAL DRUG-PROFILE
CLENBUTEROL:
 Powerful bronchodilator used to treat asthma and other related breathing problems.
 Used as thermogenic – fat loss
 Very popular fat burner among AAS user and competitive body builders.
 Beta-2 receptor stimulator – enhance metaboic rate – increase fat loss.
 Not well-suited for Obese or significantly overweight.
 Best time to use is when one is already lean – to get rid of stubborn fat.
SIDE EFFECTS: can be strong
 Jittery feeling
 Shaky hands
 Increased sweating
 Increased body temperature
 Paplitation and high blood pressure in abusers
 Headache, nausea, vomiting and Insomnia
 Muscle cramps