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angina
• B2 selective blocker
• Ca 2+ channel blocker
Stable
angina
• Sublingual nitrat Acute
Angina’s Treatment
General guideline Of
AHA guideline for Unstable angina and
NSTEMI
• Class I: tdp bukti dan/ general
agreement bahwa efektif dan
bermanfaat
• Class II: tdp bbrp bukti yang
bertentangan dan/ pendapat
bahwa bermanfaat
• Class III: tdp bukti dan/ general
agreement bahwa tdk bermanfaat
bahkan dpt harmful
Class I: analgesic and anti-ischemic
• 1. Bed/chair rest with continuous
ECG monitoring is recommended
for all UA/NSTEMI patients during
the early hospital phase. (Level of
Evidence: C)
• 2. Supplemental oxygen should be
administered to patients with
UA/NSTEMI with an arterial
saturation less than 90%,
respiratory distress, or other high-
Class I : Antiplatelet therapy
• 1. Aspirin should be administered to UA/NSTEMI patients as
soon as possible after hospital presentation and continued
indefinitely in patients not known to be intolerant of that
medication. (Level of Evidence: A)(Figs. 6 and 7; Box A)
• 2. Clopidogrel (loading dose followed by daily maintenance
dose)†should be administered to UA/NSTEMI patients who
are unable to take ASA because of hypersensitivity or major
gastrointestinal intolerance. (Level of Evidence: A)(
Figs. 6 and 7; Box A)
• 3. In UA/NSTEMI patients with a history of gastrointestinal
bleeding, when ASA and clopidogrel are administered alone
or in combination, drugs to minimize the risk of recurrent
gastrointestinal bleeding (e.g., proton-pump inhibitors)
should be prescribed concomitantly. (Level of Evidence: B)
Class I : Antiplatelet therapy
• 4. For UA/NSTEMI patients in whom an initial invasive strategy
is selected, antiplatelet therapy in addition to aspirin should be
initiated before diagnostic angiography (upstream) with either
clopidogrel (loading dose followed by daily maintenance dose)†
or an IV GP IIb/IIIa inhibitor. (Level of Evidence: A)Abciximab as
the choice for upstream GP IIb/IIIa therapy is indicated only if
there is no appreciable delay to angiography and PCI is likely to
be performed; otherwise, IV eptifibatide or tirofiban is the
preferred choice of GP IIb/IIIa inhibitor. (Level of Evidence: B)
• 5. For UA/NSTEMI patients in whom an initial conservative (i.e.,
noninvasive) strategy is selected (see Section IV.C), clopidogrel
(loading dose followed by daily maintenance dose)†should be
added to ASA and anticoagulant therapy as soon as possible
after admission and administered for at least 1 month (Level of
Evidence: A)and ideally up to 1 year. (Level of Evidence: B)(Fig. 7
; Box C2)
Class I : Antiplatelet therapy
• 6. For UA/NSTEMI patients in whom an initial conservative
strategy is selected, if recurrent symptoms/ischemia, HF, or
serious arrhythmias subsequently appear, then diagnostic
angiography should be performed (Level of Evidence: A)(Fig. 7;
Box D). Either an IV GP IIb/IIIa inhibitor (eptifibatide or
tirofiban; Level of Evidence: A) or clopidogrel (loading dose
followed by daily maintenance dose; Level of Evidence: A)†
should be added to ASA and anticoagulant therapy before
diagnostic angiography (upstream). (Level of Evidence: C)