Dr. Moutafa ElHousinie Enterica Typhoid fever Diarrhea Gastroenteritis Enterica, typhoid and paratyphoid fever A world-wide disease 17 million cases per year, 600000 deaths Endemic in less developed countries Epidemics and outbreaks may occur on top of endemic status S. Para occurs sporadically or outbreaks Clinical Picture IP 1-3 weeks Fever, headache, abdominal discomfort, relative bradycardia, cough and abdominal rosy spots on 7th day of fever May pass un-noticed as mild or sub-clinical case with the development of chronic carrier status S. paratyphi – less severe and less frequently diagnosed Organism and source Salmonella typhi, S. paratyphi A, B and C Intestines of humans (rarely in S paratyphi in domestic animals) Excreted in stools and urine of humans Humans as cases or carriers – more urinary carriers with Schistosomiasis Carriers may be temporary or chronic Transmission Human to food or drinks including milk ----- carriers among food handlers --- inadequate toilet hygiene Sewage to drinking water ---- piping system through shellfish raw vegetables or fruits The organism is resistant to dryness and cold temperature (contaminated water used to make ice) Flies especially in summer Epidemiology In endemic areas more common in preschool and school children (5-19) More in summer. Young males. Common foods as camps, prisons, hotels and restaurants. Urban slums Low socio-economic status Diagnosis Blood culture Widal test: a rising titre Stool and urine culture Therapeutic test Prevention General: Environmental sanitation Food and water sanitation Health education for toilet hygiene Specific Vaccination TAB heat killed phenol-preserved 0.5 ml – 4weeks – 1ml SC To specific groups Oral live avirulant vaccine Control Case Notification Isolation Disinfection: concurrent and terminal Treatment Release: 3 negative successive 24 hours apart stools. 1st after four weeks from onset Control Contacts Under surveillance for 3 weeks TAB vaccine Search for carrier Control Environment: (also applied to epidemic measures) Search for source: carriers among food handlers, sewage leakage ..etc Super-chlorination of water Supervision for restaurants, hotels, camps ..etc Health education programs for food and water sanitation Diarrhea and Dysentries Share the epidemiology of Enterica
Diarrhea > 3 passes of loose stools/day
Dysentery tenesmus stools mucus and blood Gastroenteritis vomiting and diarrhea Travellers’ diarrhea self-limited condition Diarrhea and Dysentries E. coli most frequent Rota virus, Shigella, Salmonella ------------------------ sometimes Staph. Aureus, Giardia, chlosteridia ------------------- less common Vibrios and E. histolytica ---------------------------------- rare Gastro-enteritis Vomiting + Diarrhea ± fever Dehydration ----- the main complication Viral, Bacterial or Parasitic IP hours, days, weeks according to agent The main cause of deaths in infants and preschool children in less developed countries with bad environmental sanitation. Gastro-enteritis Epidemiology Both sexes Two months – Five years Summer Weaning Malnutrition Low socio-economic standards Lack of environmental hygiene: food, water and flies Gastro-enteritis Control Early case finding (health education to mothers) Rehydration therapy: ORS for mild – moderate cases or IV fluids for severe cases Chemotherapy Diet therapy Treatment of specific causes ORS Saline = water + NaCl + KCl + NaHCO3 Glucose < 20% added to facilitate absorption of water and electrolytes Packets…add to each 100 ml of safe water and give by spoon The main cause of the drop of IMR during the last 20 years. Gastro-enteritis Prevention Health education Health promotion Environmental sanitation Specifics for specific infections